A5087058717- Advanced biosensing and bioanalysis techniques
- Chemical Synthesis and Analysis
- Supercapacitor Materials and Fabrication
- Hydrogels: synthesis, properties, applications
- Monoclonal and Polyclonal Antibodies Research
- Electrospun Nanofibers in Biomedical Applications
- Plasmonic and Surface Plasmon Research
- Click Chemistry and Applications
- Conducting polymers and applications
- 3D Printing in Biomedical Research
- Transition Metal Oxide Nanomaterials
- Molecular Junctions and Nanostructures
- Advanced Sensor and Energy Harvesting Materials
- Connective tissue disorders research
- DNA and Biological Computing
- Electrochemical Analysis and Applications
- RNA modifications and cancer
- Advanced battery technologies research
- Biosensors and Analytical Detection
- Computational and Text Analysis Methods
- Solid State Laser Technologies
- Electron and X-Ray Spectroscopy Techniques
- CO2 Reduction Techniques and Catalysts
- Water Treatment and Disinfection
- Additive Manufacturing and 3D Printing Technologies
First Affiliated Hospital of Zhengzhou University
2024
Jining Medical University
2023
Taizhou University
2023
TU Dresden
2017-2023
Pusan National University
2021-2023
University of Macau
2023
Affiliated Hospital of Jining Medical University
2023
Tongji University
2022
Bioengineering Center
2019
Chinese Academy of Sciences
2011-2018
Abstract Many features of extracellular matrices, e.g., self-healing, adhesiveness, viscoelasticity, and conductivity, are associated with the intricate networks composed many different covalent non-covalent chemical bonds. Whereas a reductionism approach would have limitation to fully recapitulate various biological properties simple structures, mimicking such sophisticated by incorporating functional groups in macromolecular system is synthetically challenging. Herein, we propose strategy...
Abstract Synthetic conductive biopolymers have gained increasing interest in tissue engineering, as they can provide a chemically defined electroconductive and biomimetic microenvironment for cells. In addition to low cytotoxicity high biocompatibility, injectability adhesiveness are important many biomedical applications but proven be very challenging. Recent results show that fascinating material properties realized with bioinspired hybrid network, especially through the synergy between...
The study of cells responding to an electroconductive environment is impeded by the lack a method, which would allow encapsulation in extracellular matrix-like 3D electroactive matrix, and more challengingly, permit simple mechanism release for further characterization. Herein, we report polysaccharide-based conductive hydrogel system formed via β-cyclodextrin-adamantane host-guest interaction. Oxidative polymerization 3,4-ethylenedioxythiophene (EDOT) presence adamantyl-modified sulfated...
We present a DNA-encoded chemical library, which allows dynamic selection followed by ligation of the encoding strands. As approach to mimic genetic recombination process adaptive immunity, technology led an enhanced enrichment factor and signal-to-noise ratio compared static libraries.
Abstract The rational combination of techniques from the fields nanotechnology, single molecule detection, and lead discovery could provide elegant solutions to enhance throughput drug screening. We have synthesized nanoarrays small pharmacophores on DNA origami substrates that are displayed either as individual ligands or fragment pairs thereby reduced feature size by several orders magnitude, compared with standard microarray techniques. Atomic force microscopy‐based single‐molecule...
DNA origami nanostructures are versatile substrates for the single‐molecule investigation of biomolecular interactions as they enable display molecular species in complex arrangements. Herein, fundamental limitations this approach explored by displaying pairs small‐molecule ligands protein trypsin on and adjusting their ligand–ligand spacing with subnanometer precision. Bidentate binding to ligand is investigated atomic force microscopy (AFM), microscale thermophoresis (MST), dynamics...
Abstract The split-and-pool method has been widely used to synthesize chemical libraries of a large size for early drug discovery, albeit without the possibility meaningful quality control. In contrast, self-assembled DNA-encoded library (DEL) allows us construct an m x n-member by mixing m-member and pre-purified sub-library. Herein, we report trio-pharmacophore DEL (T-DEL) l n members through assembling three validated sub-libraries. middle sub-library is synthesized using DNA-templated...
DNAzyme based electrochemical biosensors have the characteristics of high sensitivity and selectivity, but traditional need immobilization on electrode surface first, procedures are time consuming tedious, which limit their real application. In this study, a simple sensitive free biosensor has been proposed lead chosen as model target because severe effects toxicity. The different diffusivity electrostatic repulsion between long short DNA negatively charged ITO can be used to discriminate...
Objective The aim of this study was to elucidate the exact role microRNA-98-5p (miRNA-98-5p) in progression osteosarcoma and explore its potential mechanism. Patients methods expression levels miRNA-98-5p cell division cycle 25 (CDC25A) tissues lines were determined by quantitative Real Time-Polymerase Chain Reaction (qRT-PCR). Meanwhile, correlation between expressions CDC25A survival patients analyzed. After altering liposome transfection, CDC25A, ki67, Cyclin D1, p21, BCL2-Associated X...
Abstract The rational combination of techniques from the fields nanotechnology, single molecule detection, and lead discovery could provide elegant solutions to enhance throughput drug screening. We have synthesized nanoarrays small pharmacophores on DNA origami substrates that are displayed either as individual ligands or fragment pairs thereby reduced feature size by several orders magnitude, compared with standard microarray techniques. Atomic force microscopy‐based single‐molecule...
Research Article| July 25 2014 Dissolved air flotation separation for pretreatment of membrane bioreactor in domestic wastewater treatment Youngsuk Kim; Kim 1Civil and Environmental Engineering, University Ulsan, Ulsan City, 680-749 Korea3National Institute Research, Infrastructure Department, Drinking Water Sewerage Division, Seoul, Korea Search other works by this author on: This Site PubMed Google Scholar Donghwan Choi; Choi Meiying Cui; Cui Jeonyoul Lee; Lee Bunsu Kyungho Park; Park...
Abstract Stem cell bioengineering and therapy require different model systems materials in stages of development. If a chemically defined biomatrix system can fulfill most tasks, it minimize the discrepancy among various setups. By screening biomaterials synthesized through coacervation‐mediated self‐assembling mechanism, optimal for 2D human mesenchymal stromal (hMSC) culture osteogenesis is identified. Its utility hMSC further demonstrated coating porous bioactive glass scaffolds...
ELP hydrogels for co-delivery of aPD-L1 and GEM induced a robust antitumor immune response potentiated immunotherapy.
DNA has become a promising candidate as future data storage medium; this makes steganography indispensable in security. PCR primers are conventional secret keys steganography. Brute force testing of different will be extremely time consuming, and practically unaffordable when high-throughput sequencing is used. However, the encrypted information can sequenced read once intercepted. A new approach needed to make DNA-encoded safer, if not unhackable. Mixing information-carrying with partially...