A5052390082- Cancer Cells and Metastasis
- Cancer Genomics and Diagnostics
- Mitochondrial Function and Pathology
- CAR-T cell therapy research
- Immunotherapy and Immune Responses
- Folate and B Vitamins Research
- Nanoparticle-Based Drug Delivery
- Quantum Dots Synthesis And Properties
- Phonetics and Phonology Research
- Cancer Immunotherapy and Biomarkers
- Nuclear Structure and Function
- Advanced biosensing and bioanalysis techniques
- Speech Recognition and Synthesis
- Protease and Inhibitor Mechanisms
- Endoplasmic Reticulum Stress and Disease
- Epigenetics and DNA Methylation
- Breast Cancer Treatment Studies
- Peptidase Inhibition and Analysis
- Monoclonal and Polyclonal Antibodies Research
- Cancer, Hypoxia, and Metabolism
- Voice and Speech Disorders
University Medical Center Hamburg-Eppendorf
2019-2023
Universität Hamburg
2019-2023
Martini-Klinik
2019
Helmholtz-Zentrum Dresden-Rossendorf
2017-2018
Klinikum Fulda
2015
// Anja Feldmann 1, * , Claudia Arndt Ralf Bergmann Simon Loff 2, 3, Marc Cartellieri 4, Dominik Bachmann ** Roberta Aliperta Mirjam Hetzenecker Florian Ludwig Susann Albert Pauline Ziller-Walter Alexandra Kegler Stefanie Koristka Sebastian Gärtner Schmitz 5, 7, 8 Armin Ehninger 3 Gerhard 6, Jens Pietzsch 9 Jörg Steinbach 8, and Michael 1 Helmholtz-Zentrum Dresden-Rossendorf (HZDR), Institute of Radiopharmaceutical Cancer Research, Dresden, Germany 2 UniversityCancerCenter (UCC)...
Article15 July 2020Open Access Source DataTransparent process Characterization of circulating breast cancer cells with tumorigenic and metastatic capacity Claudia Koch Department Tumor Biology, Center Experimental Medicine, University Medical Hamburg-Eppendorf, Hamburg, Germany Search for more papers by this author Andra Kuske Simon A Joosse orcid.org/0000-0002-4296-5615 Gökhan Yigit Institute Human Genetics, Göttingen, George Sflomos orcid.org/0000-0003-2972-0549 ISREC – Swiss Cancer...
Recent treatments of leukemias with chimeric antigen receptor (CAR) expressing T cells underline their impressive therapeutic potential. However, once adoptively transferred into patients, there is little scope left to shut them down after elimination tumor or in case adverse side effects occur. This becomes special relevance if they are directed against commonly expressed associated antigens (TAAs) such as receptors the ErbB family. To overcome this limitation, we recently established a...
In cancer metastasis, single circulating tumor cells (CTCs) in the blood and disseminated (DTCs) bone marrow mediate metastasis. Because suitable biomarker proteins are lacking, CTCs DTCs with mesenchymal attributes difficult to isolate from bulk of normal cells. To establish a procedure allowing isolation such cells, we analyzed cell line BC-M1 established breast patient by stable isotope labeling amino acids culture (SILAC) mass spectrometry. We found high levels transmembrane protein CUB...
Background: Solid epithelial tumors like breast cancer are the most frequent malignancy in women. Circulating tumor cells (CTCs) frequently released from hypoxic areas into blood, where CTCs face elevated oxygen concentrations. This reoxygenation might challenge use of for liquid biopsy. Methods: We modeled this situation vitro using cell lines—MCF-7, MDA-MB-468, MDA-MB-231—and line BC-M1 established DTCs bone marrow. Cells were cultured under hypoxia, followed by a pulse 4 h, reflecting...
<b><i>Objective:</i></b> The assessment of vocal ability parameters can be made easier and more objective by computer-supported analysis systems. For this, multiple commercially available systems exist. But how strongly do the measured results one method differ from another is evaluation result replaceable or directly comparable with another? <b><i>Patients Methods:</i></b> 15 women aged 20-55 years men 18-56 took part in this prospective...
Mutations in the AAAS gene coding for nuclear pore complex protein ALADIN lead to autosomal recessive disorder triple A syndrome. Triple patients present with a characteristic phenotype including alacrima, achalasia and adrenal insufficiency. Patient fibroblasts show increased levels of oxidative stress, several vitro studies have demonstrated that nucleoporin is involved both cellular stress response steroidogenesis. It known knock-out mice lack resembling human The objective this study was...
In this letter, we report on the ability of functional fusion proteins presenting a lytic gamma peptide, to promote interactions with HeLa cells and delivery large hybrid nanostructures.
ABSTRACT Background Mutations in the AAAS gene coding for nuclear pore complex protein ALADIN lead to autosomal recessive disorder triple A syndrome. Triple patients present with a characteristic phenotype including alacrima, achalasia and adrenal insufficiency. Patient fibroblasts show increased levels of oxidative stress several vitro studies demonstrated that nucleoporin is involved cellular response steroidogenesis. We showed knock-out mice lack resembling human Thus, we hypothesized...
In this letter, we highlight that a low fraction of functional fusion proteins can significantly change the interaction complex nanohybrids with cells and induce cellular uptake.