A5031009853- Endometriosis Research and Treatment
- Uterine Myomas and Treatments
- Endometrial and Cervical Cancer Treatments
- Intestinal and Peritoneal Adhesions
- Gynecological conditions and treatments
- Reproductive System and Pregnancy
- Pelvic floor disorders treatments
- Pelvic and Acetabular Injuries
- Hernia repair and management
- Pregnancy-related medical research
- Reproductive Biology and Fertility
- Ovarian function and disorders
- Omental and Epiploic Conditions
- Bone health and osteoporosis research
- Ovarian cancer diagnosis and treatment
- Galectins and Cancer Biology
- Gastric Cancer Management and Outcomes
- Food Industry and Aquatic Biology
- Colorectal Cancer Surgical Treatments
- Enhanced Recovery After Surgery
- Minimally Invasive Surgical Techniques
- Anorectal Disease Treatments and Outcomes
- Artificial Intelligence in Healthcare
- Renal and related cancers
- Delphi Technique in Research
Semmelweis University
2016-2025
KU Leuven
2008-2013
Fund for Scientific Research
2012
Leuven Institute for Fertility and Embryology
2009-2011
Universitair Ziekenhuis Leuven
2010
Institute e-Austria Timisoara
2007
National Institute of Menthal Health, Neurology and Neurosurgery - Nyírő Gyula Hospital
2007
This study aimed to calculate costs and health-related quality of life women with endometriosis-associated symptoms treated in referral centres. A prospective, multi-centre, questionnaire-based survey measured ambulatory care 12 tertiary centres 10 countries. The enrolled a diagnosis endometriosis at least one centre-specific contact related 2008. main outcome measures were health costs, productivity loss, total quality-adjusted years. Predictors identified using regression analysis. Data...
How should endometriosis be diagnosed and managed based on the best available evidence from published literature?The current guideline provides 109 recommendations diagnosis, treatments for pain infertility, management of disease recurrence, asymptomatic or extrapelvic disease, in adolescents postmenopausal women, prevention association with cancer.Endometriosis is a chronic condition plethora presentations terms not only occurrence lesions, but also presence signs symptoms. The most...
To what extent do the management of endometriosis and symptoms that remain after treatment affect quality life in women with disease? Many had impaired continued to suffer from endometriosis-associated even though their has been managed tertiary care centres. The existing literature indicates work productivity is reduced endometriosis. However, most studies have small sample sizes, are related or examine newly diagnosed patients only. A cross-sectional questionnaire-based survey among 931...
Abstract Advances in preoperative diagnostics as well surgical techniques for the treatment of endometriosis, especially deep call a classification system, that includes all aspects disease such peritoneal ovarian and secondary adhesions. The widely accepted revised American Society Reproductive Medicine (rASRM) has certain limitations because its incomplete description endometriosis. In contrast, Enzian classification, which been implemented last decade, proved to be most suitable tool...
At present, the only way to conclusively diagnose endometriosis is laparoscopic inspection, preferably with histological confirmation. This contributes delay in diagnosis of which 6–11 years. So far non-invasive diagnostic approaches such as ultrasound (US), MRI or blood tests do not have sufficient power. Our aim was develop and validate a test high sensitivity (80% more) for symptomatic patients, without US evidence endometriosis, since this group most need test. A total 28 inflammatory...
To what extent are pain symptoms, psychological variables (anxiety, depression and distress) emotion regulation associated with women's health in endometriosis?Physical symptoms difficulties via stress negatively affect the health-related quality of life (HRQoL) women living endometriosis.There some missing links definitive treatment recovery from endometriosis. Women chronic report a decrease HRQoL an increase frequency problems, but little is known about complex relationship between these...
Abstract Background Endometriosis as a chronic gynecological disease has several negative effects on women’s life, thereby placing huge burden the patients and health system. The impact of living with endometriosis (impaired quality diverse medical experiences) is detailed in literature, however, we know less about patients’ self-management, social support, meaning life disease, needs patients. To implement proper multidisciplinary approach practice, need to have comprehensive view...
The aim of our study was to test the hypothesis that multiple-sensory small-diameter nerve fibres are present in a higher density endometrium from patients with endometriosis when compared women normal pelvis, enabling development semi-invasive diagnostic for minimal–mild endometriosis. Secretory phase samples (n = 40), obtained laparoscopically/histologically confirmed 20) and pelvis were selected biobank at Leuven University Fertility Centre. Immunohistochemistry performed localize neural...
An early semi-invasive diagnosis of endometriosis has the potential to allow treatment and minimize disease progression but no such test is available at present. Our aim was perform a combined mRNA microarray proteomic analysis on same eutopic endometrium sample obtained from patients with without endometriosis. protein fractions were extracted 49 endometrial biopsies women laparoscopically proven presence (n= 31) or absence 18) during luteal 27) menstrual phase 22) analyzed using surface...
To compare the preoperative detection of endometriosis using transvaginal sonography (TVS) supplemented by transabdominal (TAS) with surgical assessment disease, #Enzian classification for endometriosis.This was a prospective multicenter diagnostic accuracy study women undergoing TVS/TAS and radical surgery deep (DE) at different tertiary referral centers. The localization grade severity endometriotic lesions adhesions were described according to criteria classification, both ultrasound...
ABSTRACT Objective To investigate the feasibility of identifying and measuring normal sacral plexus (SP) on gynecological transvaginal ultrasound (TVS) examination. Methods This was a prospective observational study conducted at single tertiary referral center, including consecutive women undergoing TVS for various indications between November 2021 January 2022. A standardized assessment pelvic organs performed presence any congenital or acquired uterine pathology ovarian abnormality...
Abstract The International Society of Ultrasound in Obstetrics and Gynecology (ISUOG) Deep Endometriosis Analysis (IDEA) group, the European League (EEL), for Gynaecological Endoscopy (ESGE), ESHRE, Gynecologic (ISGE), American Association Laparoscopists (AAGL) Urogenital Radiology (ESUR) elected an international, multidisciplinary panel gynecological surgeons, sonographers, radiologists, including a steering committee, which searched literature relevant articles order to review provide...
Abstract Introduction There is an ongoing debate on surgical techniques for colorectal deep endometriosis (DE) and their effects gastrointestinal (GI) function. The aim of this study was to prospectively investigate the differences in pre‐ postsurgical GI function, health profiles pain symptoms women undergoing surgery symptomatic DE either with a modified segmental resection technique, so‐called nerve‐vessel sparing (NVSSR), or full thickness discoid (FTDR). Complication rates fertility...
To describe the sonomorphological changes and appearance of deep endometriosis (DE) affecting nervous tissue sacral plexus (SP).
Objective: To identify the sonomorphological appearance and to measure thickness of piriformis muscle (PM) proximal portion sacral nerve roots S1-S3 in healthy premenopausal women. Materials Methods: This prospective multicentric observational study included a consecutive series women undergoing transvaginal sonography (TVS) at two tertiary gynecological referral centers. Standardized assessment pelvic organs was performed followed by an attempt visualize right left PM their origin proximity...
Endometriosis, a benign, chronic gynecological disorder characterized by the presence of endometrial-like tissue outside uterine cavity, affects 15% women reproductive age. Galectins, family beta-galactoside-binding proteins, regulate inflammation and autoimmunity are widely expressed in tissues. This study aimed to assess Galectin-3 (Gal-3) levels serum patients with endometriosis compared asymptomatic controls investigate Gal-3 level changes over one-year follow-up period endometriosis. To...
In Brief OBJECTIVE: To test the hypothesis that differential surface-enhanced laser desorption/ionization time-of-flight mass spectrometry protein or peptide expression in plasma can be used infertile women with without pelvic pain to predict presence of laparoscopically and histologically confirmed endometriosis, especially subpopulation a normal preoperative gynecologic ultrasound examination. METHODS: Surface-enhanced analysis was performed on 254 samples obtained from 89 endometriosis...
Is it possible to replicate the previously identified genetic association of four single-nucleotide polymorphisms (SNPs), rs12700667, rs7798431, rs1250248 and rs7521902, with endometriosis in a Caucasian population? A borderline was observed for (P = 0.049). However, we could not other endometriosis-associated SNPs (rs12700667, rs7798431 rs7521902) same population. Endometriosis is considered complex disease, influenced by several environmental factors, as well interactions between them....
There is increasing evidence that intermediate and long-term bowel dysfunction may occur as a consequence of radical surgery for rectal deep endometriosis (DE). Typical symptoms include constipation, feeling incomplete evacuation, clustering stools, urgency. This described in the colorectal surgical literature low anterior resection syndrome (LARS). Within this, several studies suggested differences regarding functional outcomes could be favorable to more conservative approaches, is,...