A5009570016- Reproductive System and Pregnancy
- Immune Cell Function and Interaction
- Pregnancy and preeclampsia studies
- Hepatitis C virus research
- Endometriosis Research and Treatment
- Galectins and Cancer Biology
- Pregnancy and Medication Impact
- Systemic Lupus Erythematosus Research
- Diabetes and associated disorders
- Neuropeptides and Animal Physiology
- T-cell and B-cell Immunology
- Mycobacterium research and diagnosis
- Pancreatic function and diabetes
- Cytokine Signaling Pathways and Interactions
- Birth, Development, and Health
- Diabetes Management and Research
- Tuberculosis Research and Epidemiology
- Intestinal and Peritoneal Adhesions
- Estrogen and related hormone effects
- Reproductive Physiology in Livestock
- Hypothalamic control of reproductive hormones
- Acute Ischemic Stroke Management
- Liver Disease Diagnosis and Treatment
- Macrophage Migration Inhibitory Factor
- COVID-19 Clinical Research Studies
University of Pecs
2016-2025
Szent János Kórház
2015-2025
Ceinge Biotecnologie Avanzate (Italy)
2009
Zero to Three
2008
Hungarian Academy of Sciences
2003-2007
University College London
2007
Joslin Diabetes Center
2004-2007
Harvard University
2004-2007
University of Bonn
2006
Bipar
2003
Our goal with this study was to investigate the contribution of PD-1/PD-L1 immune-checkpoint pathway maternal immunotolerance mechanisms.Thirteen healthy pregnant women and 10 non-pregnant controls were involved in project. PBMCs DICs isolated from peripheral blood decidual tissues. After characterization different immune cell subsets, we used fluorochrome-conjugated monoclonal antibodies measure expression level PD-1, PD-L1, NKG2D, CD107a molecules by flow cytometry.We measured significant...
PROBLEM: This study was aimed at investigating the involvement of an altered cytokine pattern in immunomodulatory and anti‐abortive effects a progesterone‐induced protein (PIBF). METHOD: PIBF expression on lymphocytes healthy pregnant women from risk for premature pregnancy termination determined. In sera same TNFα quantified by bioassay using L929 cells. NK activity determined single cell cytotoxicity assay. Cytokine production or murine spleen cells measured ELISA detected...
Problem The T-cell immunoglobulin and mucin domain (TIM) family is a relatively newly described group of molecules with conserved structure important immunological functions. Identification Galectin-9 as ligand for TIM-3 has established the Galectin-9/TIM-3 pathway an negative regulator Th1 immunity tolerance induction. Data about TIM-3/Gal-9 in pathogenesis human diseases emerging, but their possible role during pregnancy not precisely known. aim our study was to investigate number,...
The anti-tumor response of human invariant NKT (NKT) cells is well established. A novel T cell subset, mucosal-associated (MAIT) cells, possesses similar regulatory properties to in autoimmune models and disease. Here, we examined the clonality four subsets expressing alphaTCR, including Valpha7.2-Jalpha33 MAIT 19 kidney brain tumors. clonotype was identified co-expressed with half In contrast, two other clonotypes (Valpha4 Valpha19) were not present Such tumors also expressed Vbeta2...
Various formats of forest bathing have been receiving increasing attention owing to their perspectives in health promotion and the treatment chronic lifestyle diseases. The majority field studies are still being conducted Far Eastern region, they often make psychological assessments mainly green season. In our pretest–posttest experiment, twelve healthy, working-age volunteers participated a 2-h leisurely walking program, first season (May) then winter (January), Mecsek Hills, next Pécs,...
Pregnancy involves significant immunological changes to support fetal development while protecting the mother from infections. A growing body of evidence supports importance immune checkpoint pathways, especially at maternal–fetal interface, although limited information is available about peripheral expression these molecules by CD8+ and CD8− NK cell subsets during trimesters pregnancy. Understanding dynamics cells their pathways crucial for elucidating roles in pregnancy maintenance...
Endometriosis, a benign, chronic gynecological disorder characterized by the presence of endometrial-like tissue outside uterine cavity, affects 15% women reproductive age. Galectins, family beta-galactoside-binding proteins, regulate inflammation and autoimmunity are widely expressed in tissues. This study aimed to assess Galectin-3 (Gal-3) levels serum patients with endometriosis compared asymptomatic controls investigate Gal-3 level changes over one-year follow-up period endometriosis. To...
ABSTRACT MAIT cells are one of the largest unconventional T cell populations and, recruited to site infection, play both protective and pathogenic roles during pulmonary viral infections. activation patterns change significantly COVID‐19, with a notable decrease in their frequency peripheral blood severe cases. In present study, we aimed investigate expression profiles various immune checkpoint pathways on MAIT, MAIT‐like non‐MAIT moderate COVID‐19 patients undergoing cytokine storm. Despite...
PROBLEM: In the presence of progesterone lymphocytes pregnant women release a 34‐ kDa protein named progesterone‐induced blocking factor (PIBF). PIBF mediates immunomodulatory and anti‐abortive effects its is related to outcome pregnancy. induces production Th2 type cytokines by activated lymphocytes. The in vivo relationship between PIBF‐ cytokine pregnancy was investigated. METHOD OF STUDY: Interleukin (IL)‐12 IL‐10 expression peripheral 111 healthy 120 at risk for premature termination...
Abstract Previous studies from our laboratory showed that the immunomodulatory effects of progesterone are mediated by a 34-kDa protein, named progesterone-induced blocking factor (PIBF). Lymphocytes women with threatened abortion fail to produce this factor. Via inducing Th2 biased cytokine production and NK activity, PIBF prevents induced pregnancy loss in mice, suggesting substitution therapy could be useful as an alternative treatment certain forms recurrent spontaneous abortions. Our...
PROBLEM: Progesterone‐dependent immunomodulation is one of the mechanisms that enables pregnancy to proceed term. Immunologic effects progesterone are mediated by a protein named progesterone‐induced blocking factor (PIBF). Among other this inhibits natural killer (NK) activity and displays an anti‐abortive effect in mice. Recently we have shown PIBF induces Th2 shift vitro. The present study was aimed at investigating vivo on cytokine production, as well relationship between NK activity,...
BackgroundPreeclampsia is a common obstetrical disease affecting 3-5% of pregnancies and representing one the leading causes both maternal fetal mortality. Maternal symptoms occur as an excessive systemic inflammatory reaction in response to placental factors released by oxidatively stressed functional impaired placenta. The T-cell immunoglobulin domain mucin (TIM) family relatively newly described group molecules with conserved structure important immunological functions. Identification...
Abstract The healthy trophoblast does not express classical HLA-A and HLA-B products; therefore, an MHC-restricted recognition of trophoblast-presented Ags is unlikely. In the decidua also in peripheral blood pregnant women, γδ T cells significantly increase number. We investigated possible role Ags. PBL isolated from women as well those at risk for premature pregnancy termination were conjugated to choriocarcinoma (JAR) transfected with nonclassical HLA (HLA-E, HLA-G). To investigate...
The programmed cell death protein 1 (PD-1) receptor has been reported to downregulate T activation effectively via binding its ligands PD-L1 or PD-L2 in a negative co-stimulatory manner. Little is known about the involvement of PD-1 mediated immunoregulation pregnancy and pregnancy-related disorders. In this work, we investigated possible role pathway pathogenesis clinical phase early-onset preeclampsia characterized by systemic maternal inflammatory response. We performed cross-sectional...