A5061570360- Reproductive System and Pregnancy
- Endometriosis Research and Treatment
- Immune Cell Function and Interaction
- Pregnancy and Medication Impact
- Pregnancy and preeclampsia studies
- Neuropeptides and Animal Physiology
- Galectins and Cancer Biology
- Estrogen and related hormone effects
- T-cell and B-cell Immunology
- Cytokine Signaling Pathways and Interactions
- Preterm Birth and Chorioamnionitis
- Viral gastroenteritis research and epidemiology
- Pregnancy-related medical research
- Birth, Development, and Health
- Omental and Epiploic Conditions
- Multiple Myeloma Research and Treatments
- Peptidase Inhibition and Analysis
- Glycosylation and Glycoproteins Research
- RNA Interference and Gene Delivery
- Chemokine receptors and signaling
- Ovarian cancer diagnosis and treatment
- Cardiovascular, Neuropeptides, and Oxidative Stress Research
- Bone health and treatments
- Reproductive Biology and Fertility
- Hormonal Regulation and Hypertension
University of Pecs
2016-2025
Szent János Kórház
2014-2023
Országos Pszichiátriai és Neurológiai Intézet
2018
Hôpital Purpan
2005-2013
Université de Toulouse
2011-2013
Inserm
2004-2013
Centre de Physiopathologie de Toulouse-Purpan
2004-2013
Université Toulouse III - Paul Sabatier
2007-2011
Centre National de la Recherche Scientifique
2011
Schiller International University
2005
Problem The T-cell immunoglobulin and mucin domain (TIM) family is a relatively newly described group of molecules with conserved structure important immunological functions. Identification Galectin-9 as ligand for TIM-3 has established the Galectin-9/TIM-3 pathway an negative regulator Th1 immunity tolerance induction. Data about TIM-3/Gal-9 in pathogenesis human diseases emerging, but their possible role during pregnancy not precisely known. aim our study was to investigate number,...
Peripheral lymphocytes from healthy pregnant women secrete a mediator protein named the progesterone-induced blocking factor (PIBF) that exerts an immunomodulatory function and contributes to maintenance of pregnancy in mice. The gene coding for PIBF mRNA has been cloned sequenced, now recombinant human is available. aim this study was develop ELISA test determining concentrations biological samples women. We determined urinary 86 nonpregnant individuals almost 500 by ELISA. During normal...
Abstract CD160 is an Ig-like activating NK cell receptor expressed on the majority of circulating cells. This population corresponds to nonproliferating, highly cytolytic, CD56dimCD16+ subset. engagement by HLA-C molecules mediates cytotoxic function. In this study, we report that upon specific activation physiological ligand HLA-C, or Ab cross-linking, CD160+ peripheral blood cells produce IFN-γ, TNF-α, and IL-6. unique CD160-mediated cytokine production differs from one observed after CD16...
Pregnancy involves significant immunological changes to support fetal development while protecting the mother from infections. A growing body of evidence supports importance immune checkpoint pathways, especially at maternal–fetal interface, although limited information is available about peripheral expression these molecules by CD8+ and CD8− NK cell subsets during trimesters pregnancy. Understanding dynamics cells their pathways crucial for elucidating roles in pregnancy maintenance...
Endometriosis, a benign, chronic gynecological disorder characterized by the presence of endometrial-like tissue outside uterine cavity, affects 15% women reproductive age. Galectins, family beta-galactoside-binding proteins, regulate inflammation and autoimmunity are widely expressed in tissues. This study aimed to assess Galectin-3 (Gal-3) levels serum patients with endometriosis compared asymptomatic controls investigate Gal-3 level changes over one-year follow-up period endometriosis. To...
Background: Medication-related osteonecrosis of the jaw (MRONJ) is a common adverse event following antiresorptive treatment, leading to chronic inflammation and exposed, necrotic bone surfaces in jawbone. There an increasing recognition role compositional changes colonizing members oral microbiota implicated triggering and/or maintaining MRONJ. The aim our study was characterize culturable non-culturable microbiota-with particular focus on Actinomyces spp. Actinomyces-like organisms...
PROBLEM: Due to the lack of classical HLA antigens on trophoblast, fetal are possibly presented in a non major histocompatibility complex (MHC) restricted way. Decidual γδ T cells, which significantly increase number during pregnancy, might play role recognition and also determining quality response these antigens. Our study was aimed at investigating this cell population progesterone‐dependent immunomodulation. METHOD OF STUDY: Peripheral lymphocytes from healthy pregnant women habitual...
Abstract Previous studies from our laboratory showed that the immunomodulatory effects of progesterone are mediated by a 34-kDa protein, named progesterone-induced blocking factor (PIBF). Lymphocytes women with threatened abortion fail to produce this factor. Via inducing Th2 biased cytokine production and NK activity, PIBF prevents induced pregnancy loss in mice, suggesting substitution therapy could be useful as an alternative treatment certain forms recurrent spontaneous abortions. Our...
Abstract PIBF was previously identified as a 34 kDa immunomodulatory molecule secreted by pregnancy lymphocytes and is thought to play crucial role in preventing rejection of the embryo maternal immune response. Recent data suggested that protein also expressed progesterone receptor (PR) positive MCF‐7 breast tumor cell line. Therefore our study designed analyze expression malignant lines primary tumors both at mRNA levels. RNA analyses several human with different tissue origin paired...
Abstract Progesterone-induced blocking factor (PIBF) induces Th2-dominant cytokine production. Western blotting and EMSA revealed phosphorylation as well nuclear translocation of STAT6 inhibition STAT4 in PIBF-treated cells. The silencing by small interfering RNA reduced the effects. Because activation pathway depends on ligation IL-4R, we tested involvement IL-4R PIBF-induced activation. Although PIBF does not bind to latter with an Ab abolished activation, whereas IL-13R had no effect....
Abstract Successful pregnancy in humans has been associated with production of IL-4 by T cells at the feto–maternal interface. Soluble HLA-G5 produced trophoblasts potentially controls decidual cell cytokine profile. We studied effect on profile purified human macrophages and Ag-specific vitro. demonstrated that increased IL-12 peripheral blood macrophages. Although is known to induce IFN-γ CD4+ cells, but not after Ag presentation found this apparent paradox was due differential expression...
ABSTRACT MAIT cells are one of the largest unconventional T cell populations and, recruited to site infection, play both protective and pathogenic roles during pulmonary viral infections. activation patterns change significantly COVID‐19, with a notable decrease in their frequency peripheral blood severe cases. In present study, we aimed investigate expression profiles various immune checkpoint pathways on MAIT, MAIT‐like non‐MAIT moderate COVID‐19 patients undergoing cytokine storm. Despite...