A5027685481- Peptidase Inhibition and Analysis
- Enzyme Structure and Function
- Neuropeptides and Animal Physiology
- Photosynthetic Processes and Mechanisms
- Amino Acid Enzymes and Metabolism
- Biochemical and Molecular Research
- Biochemical Acid Research Studies
- Metal-Catalyzed Oxygenation Mechanisms
- Endometriosis Research and Treatment
- Gestational Trophoblastic Disease Studies
- Mass Spectrometry Techniques and Applications
- Signaling Pathways in Disease
- Hemoglobin structure and function
- Microbial Metabolic Engineering and Bioproduction
- Reproductive System and Pregnancy
- Glycosylation and Glycoproteins Research
- Protein Structure and Dynamics
- Enzyme-mediated dye degradation
- Toxin Mechanisms and Immunotoxins
- Crystallization and Solubility Studies
- Sexual Differentiation and Disorders
- Chemical Synthesis and Analysis
- Analytical Chemistry and Chromatography
- Microbial Natural Products and Biosynthesis
- Pharmacogenetics and Drug Metabolism
University of Warwick
2013-2024
University of Pecs
2024
Institute of Biochemistry
2024
Szent János Kórház
2023-2024
University of Miskolc
2021-2024
Semmelweis University
1992-2022
University of Szeged
2022
BM Központi Kórház
2021
Buda Health Center
2010-2014
North Atlantic Treaty Organization
2012
BACKGROUNDLack of a non-invasive diagnostic test contributes to the long delay between onset symptoms and diagnosis endometriosis. The aim this study was evaluate combined performance six potential plasma biomarkers in
The valorization of aromatic heteropolymer lignin is an important unsolved problem in the development a biomass-based biorefinery, for which novel high-activity biocatalysts are needed. Sequencing genomic DNA lignin-degrading bacterial strain Sphingobacterium sp. T2 revealed no matches to known genes. Proteomic two manganese superoxide dismutase proteins were found partially purified extracellular fractions. Recombinant MnSOD1 and MnSOD2 both show high activity oxidation Organosolv Kraft...
The aim of our study was to test the hypothesis that multiple-sensory small-diameter nerve fibres are present in a higher density endometrium from patients with endometriosis when compared women normal pelvis, enabling development semi-invasive diagnostic for minimal–mild endometriosis. Secretory phase samples (n = 40), obtained laparoscopically/histologically confirmed 20) and pelvis were selected biobank at Leuven University Fertility Centre. Immunohistochemistry performed localize neural...
D-cycloserine is an antibiotic which targets sequential bacterial cell wall peptidoglycan biosynthesis enzymes: alanine racemase and D-alanine:D-alanine ligase. By a combination of structural, chemical mechanistic studies here we show that the inhibition ligase by proceeds via distinct phosphorylated form drug. This insight reveals bimodal mechanism action for single on different enzyme has significance design future inhibitor molecules based this structure.
The identification of enzymes responsible for oxidation lignin in lignin‐degrading bacteria is interest biotechnological valorization to renewable chemical products. genome sequences two bacteria, Ochrobactrum sp., and Paenibacillus contain no B‐type DyP peroxidases implicated degradation other but putative multicopper oxidase genes. Multi‐copper CueO from sp. was expressed reconstituted as a recombinant laccase‐like enzyme, kinetically characterized. shows activity β‐aryl ether biphenyl...
Structure determination of the inactive S554A variant prolyl oligopeptidase complexed with an octapeptide has shown that substrate binding is restricted to P4-P2′ region. In addition, it revealed a hydrogen bond network potential catalytic importance not detected in other serine peptidases. This involves unique intramolecular between P1′ amide and P2 carbonyl groups another P2′ Nε2 histidine 680 residue. It argued both bonds promote proton transfer from imidazolium ion leaving group. Another...