A5042768239- Microplastics and Plastic Pollution
- Gut microbiota and health
- Advanced Sensor and Energy Harvesting Materials
- Tryptophan and brain disorders
- Graphene and Nanomaterials Applications
- Gastrointestinal motility and disorders
- biodegradable polymer synthesis and properties
- CAR-T cell therapy research
- Immune Cell Function and Interaction
- Transgenic Plants and Applications
- Chemical Reactions and Isotopes
- Nanocomposite Films for Food Packaging
- Photoreceptor and optogenetics research
- Neuroinflammation and Neurodegeneration Mechanisms
- Cancer Research and Treatments
- Molecular spectroscopy and chirality
- Phosphodiesterase function and regulation
- Diet and metabolism studies
University of Veterinary Medicine
2024-2025
University of Veterinary Medicine Hannover, Foundation
2024-2025
Universitätsklinikum Würzburg
2024
Abstract The efficacy of antitumor immunity is associated with the metabolic state cytotoxic T cells, which sensitive to tumor microenvironment. Whether ionic signals affect adaptive immune responses unclear. In present study, we show that there an enrichment sodium in solid tumors from patients breast cancer. Sodium chloride (NaCl) enhances activation and effector functions human CD8 + enhanced fitness. These NaCl-induced effects translate into increased cell killing vitro vivo....
The gastrointestinal tract (GIT) serves both in the digestion of food and uptake nutrients but also as a protective barrier against pathogens. Traditionally, research this area has relied on animal experiments, there's growing demand for alternative methods that adhere to 3R principles-replace, reduce, refine. Porcine organoids have emerged promising tool, offering more accurate vitro replication vivo conditions than traditional cell models. One major challenge with intestinal is their...
Emerging data have highlighted a correlation between microbiome composition and cancer immunotherapy outcome. While commensal bacteria their metabolites are known to modulate the host environment, contradictory effects lack of mechanistic understanding impede translation microbiome-based therapies into clinic. In this study, we demonstrate that abundance metabolite pentanoate is predictive for survival chimeric antigen receptor (CAR) T cell patients in two independent cohorts. Its...
<title>Abstract</title> Based on their ubiquitous distribution in various ecosystems, plastic particles of different origin and sizes enter the (human) food chain, are ingested reach gastrointestinal tract, where they interact with intestinal (epithelial) tissue. To a certain extent, may or cross epithelium, getting into contact enteric neurons. Therefore, potential risk for health has been suggested early on. In current study, we aimed to investigate effect polystyrene nano- (100 nm)...
The porcine colon epithelium plays a crucial role in nutrient absorption, ion transport, and barrier function. However ethical concerns necessitate the development of alternatives to animal models for its study. objective this study was develop characterise two?dimensional (2D) vitro model colonic organoids that closely mimics native tissue, thereby supporting research gastrointestinal physiology, pathology, pharmacology. Porcine crypts were isolated cultured three-dimensional (3D) organoid...