A5061934612- CAR-T cell therapy research
- Nanowire Synthesis and Applications
- Lysosomal Storage Disorders Research
- Electrochemical sensors and biosensors
- Transgenic Plants and Applications
- Protein Structure and Dynamics
- Analytical Chemistry and Sensors
- Chemical Synthesis and Analysis
- Virus-based gene therapy research
- Electrochemical Analysis and Applications
- Growth Hormone and Insulin-like Growth Factors
- RNA and protein synthesis mechanisms
- Cancer Research and Treatments
RWTH Aachen University
2020
École Polytechnique Fédérale de Lausanne
2012
Southern California University for Professional Studies
1998
University of Southern California
1998
Abstract A molecular‐dynamics (MD) simulation study of two heptapeptides containing α ‐ and β ‐amino acid residues is presented. According to NMR experiments, the peptides differ in dominant fold when solvated MeOH: peptide 3 adopts predominantly ‐hairpin‐like conformations, while 8 a 14 / 15 ‐helical fold. The MD simulations largely reproduce experimental data. Application NOE atomatom distance restraining improves agreement with data, but reduces conformational sampling. Peptide shows...
A novel electrochemical impedance spectroscopy (EIS) sensor design, based on a standard interdigitated electrode arrangement in which the working consists of gold and combined counter reference electrodes polypyrrole doped with polystyrene sulfonate (PPy:PSS), is evaluated for biosensing applications. The performance successfully proved by immobilization thiolated biotin as self‐assembled monolayer (SAM), followed streptavidin biotinylated horseradish peroxidase. It shown that specific...
Emerging data have highlighted a correlation between microbiome composition and cancer immunotherapy outcome. While commensal bacteria their metabolites are known to modulate the host environment, contradictory effects lack of mechanistic understanding impede translation microbiome-based therapies into clinic. In this study, we demonstrate that abundance metabolite pentanoate is predictive for survival chimeric antigen receptor (CAR) T cell patients in two independent cohorts. Its...