A5080914821- Inhalation and Respiratory Drug Delivery
- Air Quality and Health Impacts
- 3D Printing in Biomedical Research
- Coal and Its By-products
- Tissue Engineering and Regenerative Medicine
- Online and Blended Learning
- Neonatal Respiratory Health Research
- Vehicle emissions and performance
- Biotechnology and Related Fields
- Innovative Teaching and Learning Methods
- Cancer Cells and Metastasis
- Innovative Teaching Methods
- Noise Effects and Management
- Respiratory Support and Mechanisms
- Nanoparticles: synthesis and applications
- Problem and Project Based Learning
- Birth, Development, and Health
- Organizational Learning and Leadership
- Energy and Environment Impacts
- Student Assessment and Feedback
- Mining and Resource Management
- Health, Environment, Cognitive Aging
- Reflective Practices in Education
- Cystic Fibrosis Research Advances
- Clay minerals and soil interactions
Cardiff University
2010-2024
Background Ship engine emissions are important with regard to lung and cardiovascular diseases especially in coastal regions worldwide. Known cellular responses combustion particles include oxidative stress inflammatory signalling. Objectives To provide a molecular link between the chemical physical characteristics of ship emission they elicit identify potentially harmful fractions shipping aerosols. Methods Through an air-liquid interface exposure system, we exposed human cells under...
The respiratory tract is the primary site of exposure to airborne compounds, with bronchial epithelium providing one first lines defence. A growing need exists for an accurate in vitro model epithelium. Here, normal human epithelial (NHBE) cells cultured at air/liquid interface create a fully differentiated, in-vivo-like Developmental characterisation includes (i) trans-epithelial electrical resistance, (ii) morphology and (iii) cell specific stains/markers. It concluded that...
Svalbard is an arctic archipelago where coal mining generates all electricity via the local coal-fired power station. Coal combustion produces a waste product in form of particulate matter (PM) fly ash (CFA), derived from incombustible minerals present feed coal. PM ≤10 µm (diameter) may be “inhaled” into human respiratory system, and particles ≤2.5 enter distal alveoli to disrupt normal pulmonary functions trigger disease pathways. This study discovered that CFA contained unusually high...
In this article, we provide an overview of the experimental workflow by Lung and Particle Research Group at Cardiff University, that led to development two in vitro lung models - normal human bronchial epithelium (NHBE) model lung-liver model, Metabo-Lung™. This work was jointly awarded 2013 Lush Science Prize. The NHBE is a three-dimensional, vitro, tissue-based epithelium, Metabo-Lung involves co-culture with primary hepatocytes, thus permitting biotransformation inhaled toxicants...
Approximately 1 million women smoke during pregnancy despite evidence demonstrating serious juvenile and/or adult diseases being linked to early-life exposure cigarette smoke. Susceptibility could be determined by factors in previous generations, that is, prenatal or “maternal” exposures toxins. Prenatal airborne pollutants such as mainstream has been shown induce insults (i.e., gene changes) Offspring serve biomarkers for disease later life. In this investigation, we have evaluated...
Exposure to indoor air in moisture damaged buildings is associated with deteriorating respiratory health, assumedly due emissions from microbial growth and wet building materials. Previous studies of toxicological effects mouldy house microbes have indicated that inflammation cell death are important mechanisms. Aiming gain further insight into function epithelia, we studied the responses normal human bronchial epithelium (NHBE) model after exposure settled dust samples collected (n=6)...