A5039233437- Acute Myeloid Leukemia Research
- Acute Lymphoblastic Leukemia research
- Mesenchymal stem cell research
- Periodontal Regeneration and Treatments
- Veterinary Equine Medical Research
- Virus-based gene therapy research
- Retinoids in leukemia and cellular processes
- Lymphoma Diagnosis and Treatment
- Tissue Engineering and Regenerative Medicine
- Protein Degradation and Inhibitors
- Ubiquitin and proteasome pathways
- T-cell and Retrovirus Studies
- Diabetic Foot Ulcer Assessment and Management
- RNA modifications and cancer
- Cancer-related gene regulation
- Immune cells in cancer
- Research on Leishmaniasis Studies
- RNA Research and Splicing
- Platelet Disorders and Treatments
- Parasites and Host Interactions
- Nuclear Structure and Function
- Osteoarthritis Treatment and Mechanisms
- Wound Healing and Treatments
- Hematopoietic Stem Cell Transplantation
- Biochemical and Molecular Research
Universidade Federal de Santa Maria
2014-2025
Universidade de São Paulo
2011-2023
University of Veterinary Medicine
2023
Clinics Hospital of Ribeirão Preto
2011-2016
Ludwig-Maximilians-Universität München
2004-2014
National Institute of Standards and Technology
2010
Helmholtz Zentrum München
2008
LMU Klinikum
2007
Munich Leukemia Laboratory (Germany)
2006
Abbott (Germany)
1954
Vassobia breviflora belongs to the Solanaceae family, possessing biological activity against tumor cells and is a promising alternative for therapy. The aim of this investigation was determine phytochemical properties V. using ESI-ToF-MS. cytotoxic effects extract were examined in B16-F10 melanoma relationship if any purinergic signaling involved. antioxidant total phenols, (2,2-diphenyl-1-picrylhydrazyl (DPPH), 2,2′-azino-bis (3-ethylbenzothiazoline-6-sulfonic acid (ABTS) analyzed, as well...
ABSTRACT: To determine species-specific reference values for ophthalmological tests is essential to diagnose ocular conditions. This study measured and ultrasonographic parameters of the eye captive coatis (Nasua nasua). Data obtained during routine physical examination were from twelve (24 eyes), two five years old, males seven females, clinically healthy. Blood collection evaluation using Schirmer tear test 1 (STT 1), measurement intraocular pressure (IOP) central corneal thickness (CCT),...
Genomic aberrations involving ETV6 on band 12p13 are amongst the most common chromosomal abnormalities in human leukemia. The translocation t(6;12)(q23;13) a childhood B-cell acute lymphoblastic leukemia (ALL) cell line fuses with putative long non-coding RNA gene STL. Linking STL properties to has so far been difficult. Here, we describe novel gene, OSTL (annotated as RNF217 Genbank), which shares first exon and CpG island but is transcribed opposite direction. Human codes for highly...
The objective of this study was to evaluate the effects Bacillus subtillis PB6, chromium propionate or a combination two on performance, egg and eggshell quality, nutrient metabolizability serum biochemistry layer breeders. White Plymouth Rock Red Rhodes Island breeder hens at 55 weeks age were allocated in individual cages using completely randomized block design with 16 replicates. Hens fed control, control + probiotic (500 g/ton subtilis PB6), CrProp (50 propionate) diets from 70 age....
Impairment of CCAAT Enhancer Binding Protein alpha (CEBPA) function is a common finding in acute myeloid leukemia; nevertheless, its relevance for promyelocytic leukemia pathogenesis unclear. We analyzed the expression and assessed methylation status core upstream promoters CEBPA at diagnosis. Patients with (n=18) presented lower levels compared to healthy controls (n=5), but higher than those t(8;21) (n=9) inv(16) (n=5). Regarding promoter, we detected no 39 samples or 8 from controls. In...
The t(10;11)(p13;q14) translocation results in the fusion of CALM (clathrin assembly lymphoid myeloid leukemia protein) and AF10 genes. This is observed acute myeloblastic (AML M6), lymphoblastic (ALL) malignant lymphoma. Using a yeast two-hybrid screen, four half LIM domain protein 2 (FHL2) was identified as interacting protein. Recently, high expression FHL2 breast, gastric, colon, lung well prostate cancer shown to be associated with an adverse prognosis. interaction between confirmed by...
ABSTRACT: To evaluate the effect of supplementation iron dextran on blood variables and metabolism in lambs experimentally infected by Haemonchus contortus, four experimental groups were used: uninfected non-supplemented animals (GI); supplemented with (GII); (GIII); (GIV). Groups II IV received 10,000 larvae (L3) III three doses (20mg/kg) intramuscularly seven days interval. Blood faeces samples collected 10 (D10), 17 (D17), 24 (D24), 31 (D31), order to determine red cell counts,...
Physiologically, feline platelets are more reactive and prone to aggregation, which interferes with platelet counts using automated counters manual methods. The use of aminoglycoside amikacin in association EDTA has proven be efficient preventing aggregates cases pseudo thrombocytopenia (PTP) people.This study evaluated the efficacy aggregation EDTA-containing blood samples investigated possible effects on hematologic measurands.Blood (1.0 mL) collected from 100 healthy cats were stored two...
// Antonio R. Lucena-Araujo 1, 2 , Juan L. Coelho-Silva Diego A. Pereira-Martins Carolina Thomé 3 Priscila S. Scheucher 1 Ana P. Lange Helder H. Paiva Benjamin T. Hemmelgarn 4 Mariana C. Morais-Sobral 5 Elisa Azevedo 6 Pedro Franca-Neto Rafael F. Franca Cleide Silva Alexandre Krause Eduardo M. Rego Department of Internal Medicine, Medical School Ribeirao Preto, Brazil Genetics, Federal University Pernambuco, Recife, Center for Cell Based Therapy, Sao Paulo, The Ohio State University,...
ABSTRACT: In healthy cartilage, chondrocytes maintain an expression of collagens and proteoglycans are sensitive to growth factors cytokines that either enhance or reduce type II collagen synthesis. osteoarthritis, pro-inflammatory cytokines, such as IL-6, induce overexpression metalloproteinases (MMP) decreasing synthesis aggrecan. Use chondroprotectors agents, Platelet-Rich Plasma (PRP) triamcinolone (TA) alternatives the progression joint damage. this study, we used extracted from...
ABSTRACT We investigated the local and systemic effects of hyperbaric oxygen therapy in BALB/C mice, exposed to two different exposure times, under 2.4 atmosphere (ATM). Fifteen animals were divided into three groups (GI, GII Control) underwent a surgical excision skin fragment approximately one square centimeter dorsal region. The wounds treated monitored for 21 days. In control group, wound was cleaned once day with sterile 0.9% NaCl solution. GI mice submitted daily 30 or 60minutes...
Antimony is a chemical element used in the therapy of parasitic diseases with promising anticancer potential. The aim this study was to evaluate vitro activity free or liposomal vesicle-packed antimony trioxide (AT LAT) t(15;17)(q22;q21) translocation-positive acute promyelocytic leukemia (APL) cell line NB4.Cytotoxicity analysed trypan blue exclusion, MTT assay and neutral red exclusion assay; proliferation PicoGreen®; reactive oxygen species (ROS) production DCFDA.Liposomal particles did...