A5058738669- Acute Myeloid Leukemia Research
- Cancer-related gene regulation
- RNA modifications and cancer
- RNA Research and Splicing
- Ubiquitin and proteasome pathways
- Renal and related cancers
- RNA and protein synthesis mechanisms
- Genomics and Chromatin Dynamics
- Blood disorders and treatments
- Chronic Lymphocytic Leukemia Research
- Chromatin Remodeling and Cancer
- Protein Tyrosine Phosphatases
- Cancer Mechanisms and Therapy
- Immune Cell Function and Interaction
- Microtubule and mitosis dynamics
- Cellular Mechanics and Interactions
- Immunodeficiency and Autoimmune Disorders
- Nuclear Structure and Function
- Lymphoma Diagnosis and Treatment
- Erythrocyte Function and Pathophysiology
- Myeloproliferative Neoplasms: Diagnosis and Treatment
- Genetics and Physical Performance
- Ferroptosis and cancer prognosis
- Genomic variations and chromosomal abnormalities
- Glioma Diagnosis and Treatment
Universidade de São Paulo
2016-2024
Hospital Universitário da Universidade de São Paulo
2023
Universidade Estadual Paulista (Unesp)
2021
Translational Research Institute
2019
Centro Infantil Boldrini
2019
Universidade Estadual de Campinas (UNICAMP)
2008-2018
Ludwig-Maximilians-Universität München
2005-2011
Helmholtz Zentrum München
2008
Munich Leukemia Laboratory (Germany)
2006
University of Göttingen
2000-2002
SALL4 is one out of four human homologues the <i>Drosophila</i> region-specific homeotic gene <i>spalt</i><i>(sal)</i>. Heterozygous mutations on chromosome 20q13.13→ q13.2 cause autosomal dominant Okihiro syndrome which characterized by radial limb defects, Duane anomaly and hearing loss. We have partially cloned murine homologue this gene, named <i>Sall4,</i> completed coding sequence comparison to available EST genomic sequences in GenBank...
The CATS protein was recently identified as a novel CALM interacting protein. increases the nuclear and specifically nucleolar localization of leukemogenic CALM/AF10 fusion We cloned characterized murine Cats gene. Detailed analysis expression during mouse embryogenesis showed an association with rapidly proliferating tissues. Interestingly, transcript is highly expressed in hematopoietic cells transformed by CALM/AF10. leukemia, lymphoma tumor cell lines but not non‐proliferating T‐cells or...
The CATS protein (also known as FAM64A and RCS1) was first identified a novel CALM (PICALM) interactor that influences the subcellular localization of leukemogenic fusion CALM/AF10. is highly expressed in cancer cell lines cycle dependent manner induced by mitogens. considered marker for proliferation, to control metaphase-to-anaphase transition during division. Using bait yeast two-hybrid screen we Kinase Interacting Stathmin (KIS or UHMK1) interacting partner. interaction between KIS...
The CATS (FAM64A) protein interacts with CALM (PICALM) and the leukemic fusion CALM/AF10. is highly expressed in leukemia, lymphoma tumor cell lines its levels strongly correlates cellular proliferation both malignant normal cells. In order to obtain further insight into function we performed an extensive analysis of expression during differentiation leukemia lines. While decreased erythroid, megakaryocytic monocytic differentiation, a markedly increase was observed ATRA induced granulocytic...
SALL1 has been identified as one of now three human homologs the region specific homeotic gene spalt (sal) Drosophila, which encodes a zinc finger protein characteristic structure. Mutations on chromosome 16q12.1 cause Townes-Brocks syndrome (TBS, OMIM no. 107480). In order to facilitate functional studies this in model organism, we searched for murine homolog SALL1. Here report genomic cloning, mapping, and partial expression analysis Sall1. Sequence comparison, Northern blot hybridization...
The U2AF Homology Motif Kinase 1 (UHMK1) is the only kinase that contains homology motif, a common protein interaction domain among splicing factors. Through this UHMK1 interacts with factors SF1 and SF3B1, known to participate in 3′ splice site recognition during early steps of spliceosome assembly. Although phosphorylates these vitro, involvement RNA processing has not previously been demonstrated. Here, we identify novel putative substrates evaluate contribution overall gene expression...
Prostate cancer (PCa) is an immunologically cold tumor and the molecular processes that underlie this behavior are poorly understood. In study, we investigated a primary cohort of intermediate-risk PCa (n = 51) using two NanoString profiling panels designed to study progression immune response. We identified differentially expressed genes (DEGs) pathways associated with biochemical recurrence (BCR) clinical risk. Confirmatory analysis was performed TCGA-PRAD cohort. Noteworthy DEGs included...
ARHGAP21 is a 217 kDa RhoGAP protein shown to modulate cell migration through the control of Cdc42 and FAK activities. In present work 250 kDa‐ARHGAP21 was identified by mass spectrometry. This modified form differentially expressed among lines human primary cells. Co‐immunoprecipitations in vitro SUMOylation confirmed specific modification SUMO2/3 mapped site lysine K1443. Immunofluorescence staining revealed that co‐localizes with cytoplasm membrane compartments. Interestingly, our results...
The t(10;11)(p13;q14) translocation results in the fusion of CALM (clathrin assembly lymphoid myeloid leukemia protein) and AF10 genes. This is observed acute myeloblastic (AML M6), lymphoblastic (ALL) malignant lymphoma. Using a yeast two-hybrid screen, four half LIM domain protein 2 (FHL2) was identified as interacting protein. Recently, high expression FHL2 breast, gastric, colon, lung well prostate cancer shown to be associated with an adverse prognosis. interaction between confirmed by...
Abstract PIMREG expression strongly correlates with cellular proliferation in both malignant and normal cells. Throughout embryo development, is prominent at the central nervous system. Recent studies have described high levels of transcripts different types tumors correlated patient survival tumor aggressiveness. Given emerging significance carcinogenesis its putative role context system, we investigated function gliomas, most common primary brain tumors. We performed an extensive analysis...
The aim of this study was to evaluate the expression protein tyrosine kinase 2 and phosphatase non-receptor type 11, which respectively encode focal adhesion src homology domain-containing protein-tyrosine 2, in hematopoietic cells from patients with myelodysplastic syndromes.Protein 11 expressions were analyzed by quantitative polymerase chain reaction bone marrow syndromes healthy donors.Protein did not significantly differ between normal cells.Our data suggest that despite relevance...