A5071352989- RNA Research and Splicing
- RNA modifications and cancer
- Acute Myeloid Leukemia Research
- RNA and protein synthesis mechanisms
- Enzyme Production and Characterization
- Chromatin Remodeling and Cancer
- Cancer Mechanisms and Therapy
- Cancer, Hypoxia, and Metabolism
- Protein Degradation and Inhibitors
- Glioma Diagnosis and Treatment
- Microbial Metabolites in Food Biotechnology
- Microbial Metabolic Engineering and Bioproduction
- Cellular Mechanics and Interactions
- Epigenetics and DNA Methylation
- Peroxisome Proliferator-Activated Receptors
- Education and Digital Technologies
- Erythrocyte Function and Pathophysiology
- Science and Education Research
- Neuroblastoma Research and Treatments
- Biofuel production and bioconversion
- Environmental Sustainability and Education
- Nanoparticle-Based Drug Delivery
Universidade de São Paulo
2017-2024
Ludwig-Maximilians-Universität München
2023
German Cancer Research Center
2023
Heidelberg University
2023
Deutschen Konsortium für Translationale Krebsforschung
2023
Hospital Universitário da Universidade de São Paulo
2021-2023
LMU Klinikum
2023
Munich Security Conference
2023
Universidade Estadual do Oeste do Paraná
2015-2020
The U2AF Homology Motif Kinase 1 (UHMK1) is the only kinase that contains homology motif, a common protein interaction domain among splicing factors. Through this UHMK1 interacts with factors SF1 and SF3B1, known to participate in 3′ splice site recognition during early steps of spliceosome assembly. Although phosphorylates these vitro, involvement RNA processing has not previously been demonstrated. Here, we identify novel putative substrates evaluate contribution overall gene expression...
A fotossíntese é um processo complexo que envolve a realização de várias reações que, muitas vezes, tornam este conteúdo difícil compreensão para os alunos. Neste trabalho, objetivou-se investigar se modelo didático interativo, confeccionado com materiais simples, poderia facilitar e aprendizado dos alunos referente ao tema fotossíntese. Para tanto, inicialmente foi solicitado aos uma turma do 1º ano Ensino Médio colégio público estadual oeste Paraná esquematizassem o sabiam sobre...

 Penicillium crustosum FP 11 produces two extracellular xylanase, which are designated xylanase I and II, induced by corn stover. In this work, II was purified 40-fold with a recovery yield of 9.2% using DEAE-Sephadex Sephadex G-75 gel filtration, the biochemical characteristics enzyme were compared other xylanases produced genus Penicillium. Xylanase exhibited single band on SDS–PAGE, had an apparent molecular mass 28 kDa. The optimal temperature pH activity 50ºC 5.5, respectively....
Activating colony-stimulating factor-3 receptor gene (CSF3R) mutations are recurrent in acute myeloid leukemia (AML) with t(8;21) translocation. However, the nature of oncogenic collaboration between alterations CSF3R and associated RUNX1-RUNX1T1 fusion remains unclear. In CD34+ hematopoietic stem progenitor cells from healthy donors, double oncogene expression led to a clonal advantage, increased self-renewal potential, blast-like morphology distinct immunophenotype. Gene profiling revealed...
Abstract UHMK1 (KIS) is a nuclear serine/threonine kinase that possesses U2AF homology motif and phosphorylates regulates the activity of splicing factors SF1 SF3b155. Mutations in these components spliceosome machinery have been recently implicated leukemogenesis. The fact suggests might be involved RNA processing perhaps Here we analyzed expression normal hematopoietic leukemic cells as well its function leukemia cell line. In compartment, markedly higher levels transcripts were observed...
Abstract PIMREG expression strongly correlates with cellular proliferation in both malignant and normal cells. Throughout embryo development, is prominent at the central nervous system. Recent studies have described high levels of transcripts different types tumors correlated patient survival tumor aggressiveness. Given emerging significance carcinogenesis its putative role context system, we investigated function gliomas, most common primary brain tumors. We performed an extensive analysis...
Abstract The U2AF Homology Motif Kinase 1 (UHMK1) is the only kinase that contains homology motif (UHM), a common protein interaction domain among splicing factors. Through this motif, UHMK1 interacts with factors SF1 and SF3B1, known to participate in 3’ splice site recognition during early steps of spliceosome assembly. Although phosphorylates these vitro , involvement RNA processing has not previously been demonstrated. Here, we identify novel putative substrates evaluate contribution...