A5046789469- Nanoparticle-Based Drug Delivery
- RNA Interference and Gene Delivery
- Advancements in Transdermal Drug Delivery
- Photodynamic Therapy Research Studies
- Monoclonal and Polyclonal Antibodies Research
- Advanced biosensing and bioanalysis techniques
- Skin Protection and Aging
- Advanced Drug Delivery Systems
- Immunotherapy and Immune Responses
- HER2/EGFR in Cancer Research
- Graphene and Nanomaterials Applications
- Dermatology and Skin Diseases
- Nanoplatforms for cancer theranostics
- Lipid Membrane Structure and Behavior
- Bee Products Chemical Analysis
- Virus-based gene therapy research
- Wound Healing and Treatments
- Toxin Mechanisms and Immunotoxins
- Ocular Surface and Contact Lens
- Chemotherapy-related skin toxicity
- Nonmelanoma Skin Cancer Studies
- Algal biology and biofuel production
- Dendrimers and Hyperbranched Polymers
- Cellular Mechanics and Interactions
- Tendon Structure and Treatment
Universidade Federal do Ceará
2023-2025
Universidade de São Paulo
2013-2024
University for International Integration of the Afro-Brazilian Lusophony
2020-2024
Universidade de Ribeirão Preto
2017-2019
The Ohio State University
2014-2018
Clinics Hospital of Ribeirão Preto
2017
Universidade Estadual Paulista (Unesp)
2017
Docetaxel (DTX) is a non-selective antineoplastic agent with low solubility and series of side effects. The technology pH-sensitive anti-epidermal growth factor receptor (anti-EGFR) immunoliposomes aims to increase the selective delivery drug in acidic tumor environment cells EFGR overexpression. Thus, study aimed develop liposomes based on DOPE (dioleoylphosphatidylethanolamine) CHEMS (cholesteryl hemisuccinate), using Box-Behnken factorial design. Furthermore, we conjugate monoclonal...
Short-interfering RNAs (siRNAs) are a potential strategy for the treatment of cutaneous diseases. In this context, liquid crystalline nanoparticles functionalized with specific proteins and peptide-transduction domains (PTDs), which act as penetration enhancers, promising carrier siRNA delivery through skin. Herein, hexagonal phase crystal based on monoolein (MO) and/or oleic acid (OA) containing (or lacking) cationic polymer polyethylenimine (PEI) lipid oleylamine (OAM) were membrane...
Topical drug delivery is an interesting approach to treat skin diseases and avoid pain low patient compliance in cases where a systemic required. However, the stratum corneum, which outermost layer, strongly protects body from entrance of substances, especially those hydrophilic. In this context, different physical methods have been studied overcome corneum barrier facilitate penetration drugs into or through skin. Among them, iontophoresis, low-frequency ultrasound microneedles widely...
Topical chemotherapy of skin cancers is a promising strategy for reduction side effects and improvement patient compliance. The combination the chemotherapeutic 5-fluouracil (5-FU) anti- EGFR antibody cetuximab to inhibit tumor growth. Their penetration, however, hampered by their high hydrophilicity, which could be improved encapsulation in delivery systems. Furthermore, it challenge encapsulate hydrophilic drugs. conjugation an liposome, maintaining its activity, also difficult task.Thus,...
Resveratrol (RSV), a phytoalexin from grapes and peanuts, has been reported to exhibit antiproliferative effects on various cancer cell lines. In breast cancer, RSV demonstrated exert an effect both hormone-dependent hormone-independent However, is lipophilic drug, its therapeutic could be improved through nanoencapsulation. Functionalizing polymeric nanoparticles based polycaprolactone (PCL) with polyethylene glycol 1000 tocopheryl succinate (TPGS) prolong drug circulation reduce...
Topical photodynamic therapy (PDT) has been applied to almost all types of nonmelanoma skin cancer and numerous superficial benign disorders. Strategies improve the accumulation photosensitizer in have studied recent years. Although hydrophilic phthalocyanine zinc compound, tetrasulfonate (ZnPcSO4) shown high efficiency reduced phototoxic side effects treatment brain tumors eye conditions, its use topical is currently limited by poor penetration. In this study, nanodispersions monoolein...
Liposomes have been employed to improve pharmacokinetics and reduce side effects of drugs. They can be functionalized with antibodies for targeted delivery. While the monoclonal antibody trastuzumab has in therapy HER2-positive breast cancer, resistance developed during treatment reported. Rapamycin could used combination improved therapeutic response.In this study, we aimed develop rapamycin-loaded liposomes immunoliposomes trastuzumab, characterize them evaluate their vitro...
Photodynamic therapy (PDT) using methylene blue (MB) as a photosensitizer has emerged an alternative treatment for skin cancers, such squamous cell carcinoma (SCC). To increase the cutaneous penetration of drug, some strategies are used, association nanocarriers and physical methods. Thus, herein we address development nanoparticles based on poly-Ɛ-caprolactone (PCL), optimized with Box-Behnken factorial design, topical application MB associated sonophoresis. The MB-nanoparticles were...
Nanoparticles of lyotropic liquid crystals loaded with a new photosensitizer (a chlorin derivative) were developed for use in photodynamic therapy (PDT). These systems characterized by spectrofluorimetric, dynamic light scattering, and small angle X-ray diffraction (SAXRD) analyses. In vitro vivo penetration studies animal models performed using model membranes. The had particle size 161 ± 4 nm polydispersity index 0.175 0.027. Furthermore, SAXRD demonstrated that the preparations remained...