A5035546274- Natural product bioactivities and synthesis
- Phytochemistry Medicinal Plant Applications
- Essential Oils and Antimicrobial Activity
- Phytochemicals and Antioxidant Activities
- Bee Products Chemical Analysis
- Pharmacological Effects of Natural Compounds
- Phytochemistry and Biological Activities
- Ziziphus Jujuba Studies and Applications
- Phytochemistry and Bioactive Compounds
- Healthcare during COVID-19 Pandemic
- Alkaloids: synthesis and pharmacology
- Biochemical and Structural Characterization
- Morinda citrifolia extract uses
- Public Health in Brazil
- Insect and Pesticide Research
- Plant and animal studies
- Education during COVID-19 pandemic
- Healthcare Regulation
- Genetics and Neurodevelopmental Disorders
- Agricultural and Food Sciences
- Youth, Drugs, and Violence
- Contact Dermatitis and Allergies
- Antimicrobial Peptides and Activities
- Ethnobotanical and Medicinal Plants Studies
- Sphingolipid Metabolism and Signaling
Universidade Regional Integrada do Alto Uruguai e das Missões
2020-2024
Universidade Vila Velha
2023
Universidade Federal de Santa Maria
2011-2020
Instituto de Ciências Farmacêuticas
2015
Antimicrobial, antimycobacterial and antiviral activities of crude extracts, fractions subfractions Tabernaemontana catharinensis were evaluated. Best antimicrobial results occurred with the dichloromethane (DCM) butanolic (NB) against Staphylococcus aureus, Micrococcus sp., Enterococcus faecalis Bacillus subtilis (minimal inhibitory concentration, MIC = 31.25-1000 μg/mL). Considering Gram-negative bacteria, only NB fraction was effective Proteus mirabilis Aeromonas sp. (MIC 62.5 μg/mL 250...
The main objective of this study was to demonstrate the antimicrobial potential crude extract and fractions Chenopodium ambrosioides L., popularly known as Santa-Maria herb, against microorganisms clinical interest by microdilution technique, also show chromatographic profile phenolic compounds in species. Phytochemical screening revealed presence cardiotonic, anthraquinone, alkaloids, tannins flavonoids. analysis HPLC-DAD rutin (12.5±0.20mg/g), ethyl acetate (16.5±0.37mg/g) n-butanol...
Vitex megapotamica (Sprengel) Moldenke belongs to the Verbenaceae family and is popularly known as "tarumã". The antioxidant capacity of fractions crude extract from leaves V. were determined in this study through remove reactive species phenolic compounds quantified various fractions. IC50 (DPPH) ranged 14.17 ± 0.76 37.63 0.98 µg/mL. ethyl acetate fraction might contain strongest lipid peroxidation inhibitory with an 16.36 5.09 µg/mL, being also one highest content polyphenols (522.4 1.12...
Solanum guaraniticum is a shrub belonging to the Solanaceae family popularly known in Brazil as jurubeba or false-jurubeba. The aim of this study was evaluate antioxidant activity crude extract and chloroform, ethyl acetate n-butanol fractions from its leaves, verifying ability remove reactive species identify quantify phenolic compounds. fraction showed highest amount total polyphenols (546.57 ± 2.35 mg gallic acid equivalent/g) lowest IC50 (9.11 0.75 µg/mL) by DPPH method. Furthermore,...
The essential oils obtained by hydrodistillation from the leaves of Tabernaemontana catharinensis had their composition analysed GC-MS. A total 18 substances were identified, consisting a complex mixture sesquiterpenes (83.52%), monoterpenes (5.46%) and triterpenes (4.56%). main components in oil β-caryophyllene (56.87%), α-cadinol (12.52%), 8S,13-cedran-diol (5.41%), α-terpineol (3.99%), β-eudesmol (2.54%), caryophyllene oxide (2.51%) ethyl iso-allocholate (2.03%) along with β-cubebene,...
The aim of this study was to evaluate the potential positive effect black grape juice (BGJ) on lipid peroxidation considering Total Body Irradiation (TBI) in Wistar rats. As a feasible means evaluation situ, blood serum lactate dehydrogenase (LDH) levels were evaluated as marker for heart damage from acute radiation syndrome (ARS). Twenty rats divided into four groups, two them being irradiated by gamma-rays Co-60 source. Animals treated gavage with 2 mL per day BGJ or placebo one week...
Background: Natural products with anti-oxidant properties have gained importance in recent years due to their ability neutralize free radicals or actions. Viola tricolor belong Violaceae family and is known as heartsease. The aims of the study was evaluate phenolic contents capacity different flowers leaves/ roots fractions tricolor, well identified quantify rutin fractions. Materials Methods: Total content determined using Folin-Ciocalteu assay, by 1, 1-diphenyl-2-picryl-hydrazyl (DPPH)...
Inflammatory skin diseases treatments currently used cause adverse effects. Nasturtium officinale (watercress) is popularly as an anti-inflammatory. However, until now, no study proved its effectiveness a topical treatment to inflammatory diseases. The anti-inflammatory activity of N. crude extract leaves (NoE) on irritant contact dermatitis (ICD) model croton oil-induced in mice was investigated. ICD models were induced by single (1 mg/ear; acute) or repeated (0.4 chronic; 9 days total) oil...
Heartsease, also known as wild pansy (Viola tricolor L.), contains considerable amounts of polyphenols: 109.32 ± 1.29 mg Gallic acid equivalent/g extract. This study investigates their phytoconstituents and antioxidant capacity validates a method for the quantification rutin in crude extract flowers V. incorporated gel. Much better was found [inhibition concentration (IC50) 16.00 0.78 µg/mL] than standard ascorbic (IC50 16.57 0.95 µg/mL); these excellent results may be attributable to...
Introduction: Free radicals induce numerous diseases by lipid peroxidation, protein and DNA damage. It has been reported that plant extracts have antioxidant activities to scavenge free radicals. In this present study we determined the in vitro capacity quantified of total phenolics, flavonoids, tannins alkaloids Tabernaemontana catharinensis crude extract fractions leaves. Methods: The potential was evaluated 1,1-diphenyl-2-picryl-hydrazyl radical (DPPH) scavenging thiobarbituric acid...
Tabernaemontana catharinensis, popularly known as snakeskin, is used in traditional medicine to treat skin inflammatory disorders. To confirm the topical anti-inflammatory effect of T. catharinensis leaves, we evaluated therapeutic crude extract (TcE) and its different fractions on irritant contact dermatitis model mice verified action mechanism.The qualitative phytochemical analysis TcE dichloromethane, n-butanol ethyl acetate was performed by UHPLC-ESI-HRMS. The gel accelerated stability...
Tabernaemontana catharinensis, popularly known as snake skin, has been empirically used an anti-inflammatory to treat cutaneous skin disorders. However, no study proves its effectiveness a topical anti-inflammatory.We investigated the effect of T.catharinensis leaves crude extract (TcE) in irritant contact dermatitis models mice and preliminary toxicity profile.The was evaluated by ear thickness measurement, inflammatory cell infiltration (MPO activity measurement histological procedure)...
American foulbrood (AFB) is a serious worldwide spreading disease in bees caused by Paenibacillus larvae. Plants extracts are known to decrease or inhibit the growth of these bacteria. The purpose this study was evaluate antimicrobial activity Calendula. officinalis, Cariniana domestica, and Nasturtium officinale against P. larvae toxicity bees. In vitro evaluated micro dilution method minimal inhibitory concentrations (MICs) were also determined. used test established based on MIC values...
The antioxidant capacity of the crude extract and fractions Tabernaemontana catharinensis fruits branches, was evaluated by 2,2-diphenyl-1-picrylhydrazyl (DPPH) method content polyphenols, flavonoids, alkaloids condensed tannins were determined spectrophotometric method. ethyl acetate fraction n-butanol branches showed IC50 181.82 µg/mL 78.19 µg/mL, respectively. All analyzed high performance liquid chromatography (HPLC), in quantified chlorogenic acid chloroform (8.96 mg/g), (4.31 mg/g)...
Arthritis is a chronic inflammatory disease which reduces the life quality of affected individuals. Therapeutic tools used for treating pain are associated with several undesirable effects. Buddleja thyrsoides Lam., known as 'Barbasco' or 'Cambara', mostly in disorders and possesses antirheumatic, anti-inflammatory, analgesic properties. Here, we investigated antinociceptive anti-inflammatory effects B. crude extract applied orally topically acute models an arthritic model induced by...