A5013768013- Mercury impact and mitigation studies
- Glutathione Transferases and Polymorphisms
- Environmental Toxicology and Ecotoxicology
- Agricultural and Food Sciences
- Multiple Sclerosis Research Studies
- Coffee research and impacts
- Air Quality and Health Impacts
- Carcinogens and Genotoxicity Assessment
- Ovarian function and disorders
- Paraoxonase enzyme and polymorphisms
- Acute Lymphoblastic Leukemia research
- Parkinson's Disease Mechanisms and Treatments
- Hearing, Cochlea, Tinnitus, Genetics
- Coconut Research and Applications
- Calcium signaling and nucleotide metabolism
- Calpain Protease Function and Regulation
- Pesticide Exposure and Toxicity
- Genetic Neurodegenerative Diseases
- Mitochondrial Function and Pathology
- Neuroinflammation and Neurodegeneration Mechanisms
- Adipose Tissue and Metabolism
- Pharmaceutical and Antibiotic Environmental Impacts
- Estrogen and related hormone effects
- Adipokines, Inflammation, and Metabolic Diseases
- Heavy Metal Exposure and Toxicity
Tokyo Metropolitan University
2018-2019
Universidade Federal de Santa Maria
2009-2018
The antioxidant effects of the hydro-alcoholic guaraná extract (Paullinia cupana var. sorbilis Mart.) on nitric oxide (NO) and other compounds generated from degradation sodium nitroprusside (SNP) in an embryonic fibroblast culture (NIH-3T3 cells) were evaluated. bioactive initially determined by high-performance liquid chromatography: caffeine=12.240 mg/g, theobromine=6.733 mg/g total catechins=4.336 mg/g. Cells exposed to 10 μM SNP during a 6 h period because cells exhibited >90% mortality...
Methotrexate (MTX) is a folic acid antagonist used in high doses as an anti-cancer treatment and low for the of some autoimmune diseases. MTX use has been linked to oxidative imbalance, which may cause multi-organ toxicities that can be attenuated by antioxidant supplementation. Despite effect MTX, influence gene polymorphisms on toxicity not well studied. Therefore, we analyzed here whether genetic imbalance manganese-dependent superoxide dismutase (SOD2) could have impact cytotoxic...
It now appears that obesity is associated with a low-grade inflammation of white adipose tissue resulting from chronic activation the innate immune system as interleukin-1 beta (IL-1). Previous investigations have described positive association between IL-1 +3953 (C>T) gene polymorphism (rs 1143634) and obesity, suggesting functional effects on fat mass, metabolism body mass. However, it necessary to determine if these results occur in other populations they are influenced by sex age....
We describe here an ultrasensitive and fast protocol called a GEMO assay (genomodifier capacity assay).
Environmental contamination by methylmercury (MeHg) is an enormous public health problem in world regions such as Amazonia.MeHg toxic effects seem to be influenced environmental and genetic factors.However, few studies have evaluated the influences of MeHg toxicity humans.Therefore, aim this study was evaluate influence Ala16Val manganese superoxide dismutase gene polymorphism (Ala16Val-MnSOD) on cytotoxic vitro human leukocytes exposed MeHg.Subjects were selected from 100 individuals aged...
Methylmercury (MeHg) is a well-known toxic pollutant. However, little known about the effects of this agent in an adult as consequence parental or preimaginal exposure. This study used Drosophila melanogaster to investigate whether (eggs–larvae–pupae stages) exposure could impact parameters viability, locomotor activity, and sleep patterns fruit flies. Thus, we performed two protocols. One where just parents were exposed MeHg (0–12 µM) during 24 h, then flies transferred lay eggs healthy...
Abstract Introduction: Multiple Sclerosis (MS) is a chronic inflammatory disease characterized by infiltration of cells on the Central Nervous System (CNS). There evidence that cumulative DNA damage can contribute to various mechanisms underlying MS lesions. Changes in postural balance are frequent observations subjects with MS. Objective: Evaluated index (DDI)) and patients Methods: A case-control study was conducted 28 matched for sex, age, body mass index, divided into group control. The...
To understand how the DNA answers to external agents such as cisplatin may be relevant diagnosis and treatment of hearing disorders caused by administration drug.To investigate influence on cochlea guinea pigs.Experimental study carried out with 12 pigs (Cavia porcellus). The inclusion criterion was presence Preyer's reflex distortion-product otoacoustic emissions. Guinea were divided into two groups: Control Group (CG)--made up six pigs, which we administrated saline solution during...