A5006472972- Crystallization and Solubility Studies
- X-ray Diffraction in Crystallography
- Organoselenium and organotellurium chemistry
- Sulfur-Based Synthesis Techniques
- Metal complexes synthesis and properties
- Crystallography and molecular interactions
- Catalytic Alkyne Reactions
- Catalytic C–H Functionalization Methods
- Synthesis and Biological Evaluation
- Vanadium and Halogenation Chemistry
- Lanthanide and Transition Metal Complexes
- Magnetism in coordination complexes
- Synthesis and biological activity
- Crystal structures of chemical compounds
- Organometallic Compounds Synthesis and Characterization
- Synthesis and Characterization of Heterocyclic Compounds
- Organometallic Complex Synthesis and Catalysis
- Metal-Catalyzed Oxygenation Mechanisms
- Radioactive element chemistry and processing
- Click Chemistry and Applications
- Crystal Structures and Properties
- Synthesis and Characterization of Pyrroles
- Organic Chemistry Cycloaddition Reactions
- Cholinesterase and Neurodegenerative Diseases
- Synthesis and Reactions of Organic Compounds
Universidade Federal de Santa Maria
2016-2025
University of Delhi
2023
Zhejiang University
2023
Zhengzhou University
2023
Universidade Federal da Grande Dourados
2023
Universidade Federal de Mato Grosso do Sul
2023
University of Coimbra
2022
Universidade de Caxias do Sul
2020
Freie Universität Berlin
2007
Universidade de São Paulo
2007
Combination of iron(III) chloride and diorganyl diselenides was used for cyclization arylpropiolates arylpropiolamides in formation 3-organoselenyl-2H-coumarins 3-organoselenyl-quinolinones, respectively. Systematic study to determine the ideal conditions revealed that two substrates reacted same way using identical reaction conditions. The versatility this method has been demonstrated by extension best substrate having a variety substituents. Analyses optimization also showed have dual role...
A series of 4-Se-(Te, S)-isochromenones and 3-substituted isochromenones were synthesized in good yields via FeCl3-mediated cyclization alkynylaryl esters with different diorganyl dichalcogenides. This methodology was carried out at room temperature, using inexpensive environmentally friendly iron salts as metallic source under air atmosphere. The reaction showed to be tolerant a range substituents bonded into the aromatic ring dichalcogenides well alkyl groups directly chalcogen atom....
In this paper, we report an intramolecular cyclization of benzylic-substituted propargyl alcohols promoted by iron(III) chloride and diorganyl diselenides to give 2-organoselenyl-naphthalenes via a sequential carbon-carbon/carbon-selenium bond formation. The present reaction tolerated wide range substituents in both the desired good yields with high selectivity. addition, O-acyl protected alcohol bromide were also subjected protocol giving corresponding 2-organoselenyl-naphthalenes. We found...
An iron-catalyzed system, using diorganyl diselenides as an organoselenium source, was used for the cyclization of 1,4-butyne-diols in preparation 3,4-bis(organoselanyl)-2,5-dihydrofurans. The optimized reaction conditions are compatible with many functional groups and diselenides. In addition, this catalyst system also efficient disulfides, but it did not work ditellurides. same were extended to pentyne-1,5-diol 4,5-bis(organoselanyl)-3,6-dihydro-2H-pyrans 4-amino-butynol...
Abstract A double intramolecular 5‐ endo ‐dig cyclization of butyl[2‐(phenylbuta‐1,3‐diynyl)phenyl]chalcogens has been employed in a selective preparation benzo[ b ]chalcogenopheno[2,3‐ d ]furans. Several reaction parameters were studied to determine the best conditions and we observed that (0.25 mmol) with iron(III) chloride hexahydrate (2.0 equiv.) diorganyl diselenides (1.75 at reflux dichloromethane was most appropriate give products 35–89% yields. These standard compatible many...
2-(Quinolin-4-yloxy)acetamides have been described as potent in vitro inhibitors of Mycobacterium tuberculosis growth. Herein, additional chemical modifications lead compounds were carried out, yielding highly antitubercular agents with minimum inhibitory concentration (MIC) values low 0.05 μM. Further, the synthesized active against drug-resistant strains and devoid apparent toxicity to Vero HaCat cells (IC50s ≥ 20 μM). In addition, 2-(quinolin-4-yloxy)acetamides showed intracellular...
A methodology for the synthesis and functionalization of quinolines was developed. This approach involves cyclization 2‐amino arylalkynyl ketones to 3‐(organoselanyl)‐4‐iodoquinolines through a sequential reaction pathway. The process includes: (i) in situ formation an electrophilic organoselenyl species, (ii) activation alkyne's carbon‐carbon bond via seleniranium ion intermediate, (iii) anti‐nucleophilic attack iodide on activated triple bond, (iv) subsequent condensation. resulting were...
We herein described the synthesis of various organochalcogen propargyl aryl ethers via reaction lithium acetylide intermediate with electrophilic chalcogen (sulfur, selenium, tellurium) species. Various and alkyl groups directly bonded to atom were used as electrophile. The results revealed that does not significantly depend on electronic effects substituents in aromatic ring Additional versatility this process was demonstrated respect a diverse array functionality at ethers. These ethers,...
In the present study synthesis and antinociceptive activity of bis-vinyl selenides, prepared via FeCl3 promoted reaction addition diorganyl dichalcogenides to alkynes, is described. The pharmacological results demonstrated that selenides 3a, 3d, 3h 3t elicited effect in mouse formalin test. effects are not sensitive electronic substituents on aromatic ring directly bonded selenium atom. Bis-vinyl were most promising molecules for purposes since these effective both phases test against edema....
In this paper, we report the synthesis and biological evaluation of picolylamide-based diselenides with aim developing a new series O···Se non-bonded interactions. The was performed by simple efficient synthetic route. All products were obtained in good yields their structures determined 1H-NMR, 13C-NMR HRMS. these compounds showed promising activities when tested different antioxidant assays. These amides exhibited strong thiol peroxidase-like (TPx) activity. fact one 4.66 times higher...
Abstract The copper‐catalyzed cyclization of propargylpyridines with diorganyl dichalcogenides was applied to the synthesis 2‐(organochalcogenyl)‐indolizines. A systematic study system revealed that mutual action between copper(I) iodide and is essential for formation indolizines in good yields avoiding hydrogenated indolizine. standard reaction conditions were compatible many functional groups substrates, such as methyl, chlorine, fluorine, methoxy trifluoromethyl. This protocol efficient...
Three PdII complexes were prepared from N(4)-substituted thiosemicarbazones: [Pd(aptsc)(PPh3)](NO3)•H2O, 1, [Pd(apmtsc)(PPh3)](NO3), 2, and [Pd(apptsc)(PPh3)](NO3)•H2O, 3, where PPh3 = triphenylphosphine; Haptsc 2-acetylpyridine-thiosemicarbazone; Hapmtsc 2-acetylpyridine-N(4)-methyl-thiosemicarbazone Happtsc 2-acetylpyridine-N(4)-phenyl-thiosemicarbazone. All characterized by elemental analysis, IR, UV-Vis, ¹H 31P{¹H} NMR spectroscopies, had their crystalline structures determined X-ray...
The butylselanyl propargyl alcohols reacted with iodine to afford 3-iodoselenophenes. change of nucleophile position from homopropargyl was crucial for the aromatization and formation selenophene rings. experiments revealed that bromine N-bromosuccinimide were not able cyclize alcohols; however, when source copper(II) bromide corresponding 3-bromoselenophenes obtained in good yields. In addition, reaction diorganyl diselenides catalyzed by copper(I) iodide gave 3-(organoselanyl)selenophenes....
In this paper, we report our results on the cyclization of (biphenyl-2-alkyne) derivatives to give two different types phenanthrene derivatives, 9-iodo-10-organochalcogen-phenanthrenes and 9-organochalcogen-phenanthrenes. The strategy for synthesis was based use electrophilic preparation iron(iii) chloride/diorganyl diselenide-mediated intramolecular prepare effects solvent, temperature, reaction time stoichiometry efficiency reactions were investigated. standard conditions compatible with...
A practical synthetic approach to the synthesis of 3-(organoselenyl)-imidazothiazines was developed. The methodology involved regioselective 6-endo-dig cyclization thiopropargyl benzimidazoles promoted by diorganyl diselenides and iron(III) chloride. investigation determine best reaction conditions indicated use (0.25 mmol) with (1.0 equiv) chloride (2.0 in dichloromethane at 40 °C for 30 min be optimal. Under these conditions, scope substrates evaluated varying structures giving 28 moderate...
Abstract An efficient and environmentally benign synthesis of 3‐organoselenylchromenones was accomplished via iron(III) chloride/diorganyl diselenides‐promoted intramolecular 6‐ endo‐dig cyclization alkynyl aryl ketone derivatives. The reactions proceeded cleanly under mild reaction conditions, the desired chromenone derivatives were smoothly isolated in good yields. methodology proved to be highly regioselective, giving only six‐membered regioisomers carried out using diselenide at room...
The synthesis of various Z-enynols via reaction vinyllithium intermediate with aldehydes and ketones is described. subsequent cyclization a wide variety afforded substituted furans dihydrofurans high regioselectivity under mild conditions.