A5038969467- Retinal Diseases and Treatments
- Retinal Imaging and Analysis
- Retinal and Optic Conditions
- Glaucoma and retinal disorders
- Retinal and Macular Surgery
- X-ray Diffraction in Crystallography
- Crystallization and Solubility Studies
- Augmented Reality Applications
- Metal complexes synthesis and properties
- Skin Diseases and Diabetes
- Vascular Malformations Diagnosis and Treatment
- Epigenetics and DNA Methylation
- Ophthalmology and Visual Impairment Studies
- Ocular Oncology and Treatments
- Retinopathy of Prematurity Studies
- Dupuytren's Contracture and Treatments
- Nosocomial Infections in ICU
- Organometallic Compounds Synthesis and Characterization
- Antioxidant Activity and Oxidative Stress
- Anatomy and Medical Technology
- Retinoids in leukemia and cellular processes
- Otitis Media and Relapsing Polychondritis
- Organ Transplantation Techniques and Outcomes
- Virtual Reality Applications and Impacts
- Veterinary medicine and infectious diseases
Hospital Beatriz Ângelo
2014-2025
Universidade Federal de Mato Grosso do Sul
2023-2024
Centro Hospitalar do Porto
2014-2018
Brazilian Center for Research in Energy and Materials
2017
Universidade Federal do Rio de Janeiro
2017
Universidade do Porto
2014
Hospital Braga
2012-2014
Centro Hospitalar Lisboa Norte
2014
Background/Objectives: Age-related macular degeneration (AMD) is a global cause of vision loss, with limited therapeutic options highlighting the need for effective biomarkers. This study aimed to characterize plasma DNA methyltransferase expression (DNMT1, DNMT3A, and DNMT3B) in AMD patients explore divergent patterns across different stages AMD. Methods: Thirty-eight were prospectively enrolled stratified by disease severity: eAMD, iAMD, nAMD, aAMD. Comprehensive ophthalmological...
In Brief Purpose: To evaluate the safety and efficacy of intravitreal ranibizumab in treatment choroidal neovascularization (CNV) secondary to pathologic myopia (PM). Metohds: Retrospective, multicenter, consecutive, nonrandomized, interventional case series. Participants: Twenty-six eyes 26 patients with CNV myopia; 11 previous photodynamic therapy; 15 no treatment. Follow-up: 3 or more months. Best-corrected visual acuity (BCVA), ocular coherence tomography, presence metamorphopsia were...
In Brief Purpose: The purpose of this study was to evaluate the safety and efficacy intravitreal ranibizumab after 12 months in treatment choroidal neovascularization secondary pathologic myopia. Methods: This a prospective, multicenter, consecutive, nonrandomized, interventional case series. included 34 eyes 32 patients with myopia; 13 had previous photodynamic therapy, 21 no treatment. were followed for ≥12 months. Best-corrected visual acuity, optical coherence tomography, presence...
The purpose of this study is evaluate the efficacy and safety medicinal products containing original Age-Related Eye Disease group (AREDS) formulation at doses approved in Europe (EU, control group; n = 59) with a product that adds DHA, lutein, zeaxanthin, resveratrol hydroxytyrosol to formula (intervention 50). This was multicenter, randomized, observer-blinded trial conducted patients aged 50 years or older diagnosed unilateral exudative Age related Macular Degeneration AMD. At month 12,...
Dutra-Medeiros, Marco MD, PHD; Nascimento, João MD; Henriques, José Barrão, Sandra Fernandes-Fonseca, Ana Aguiar-Silva, Nuno Moura-Coelho, Ágoas, Victor MDEditor(s): Williams, George A. Author Information
The incidence of acute pancreatitis (AP) in children has increased significantly the past two decades.All cases AP, recurrent (ARP), and chronic examined between May 2002 2012 at Hospital de Braga, Portugal, were reviewed.Patients identified by searching hospital's electronic discharge records for International Classification Disease, Ninth Revision (ICD-9) code 577.0 (acute pancreatitis). ARP was considered as or more episodes AP per year than three over a lifetime with intervening return...
The increasing prevalence of Helicobacter pylori (H. pylori) antimicrobial resistance, primarily for clarithromycin decreases the success treatment. aim this study is to determine local pattern first-line antimicrobials resistance and eradication rate.Prospective cohort H. infected patients (positive histological or cultural exams) treated at Centro Materno-Infantil do Norte from January 2013 October 2017. Susceptibility 4 antibiotics: amoxicilin, metronidazole, clarithromycin, levofloxacin...
Diabetes mellitus is a chronic metabolic disease characterized by sustained hyperglycemia leading to macro and microvascular complications. The eye one of the main organs affected this disease, being diabetic retinopathy most well-known complication cause blindness in working age population. However, ocular not only retinopathy. Other important manifestations diabetes include cataract, glaucoma, ischemic optic neuropathy, cranial nerve palsies recurrent corneal erosion syndrome. Here, we...
<b><i>Background:</i></b> First-line treatment for diabetic macular edema (DME) is usually with antivascular endothelial growth factor agents, followed by intravitreal corticosteroids as a second-line option. Long-term may offer quality of life and effectiveness benefits over short-term implants. <b><i>Objectives:</i></b> To evaluate outcomes patients persistent or recurrent DME who switched from (dexamethasone) to long-term (fluocinolone...
DNA methylation is involved in Diabetic Retinopathy progression showing a metabolic memory mechanism. However, the association of methyltransferase with diabetic macular edema still unknown. We aimed to describe differences gene expression patients different responses.A total 27 patients, aged 59-90 years, were prospectively enrolled this cross-sectional study. The participants classified into control group (CG, n = 11), responders (rDME, 9) and non-responder (nrDME, 7) after anti-vascular...
Introduction: Perifoveal exudative vascular anomalous complex (PEVAC) is an underdiagnosed macular entity. A striking feature of this entity the unresponsiveness to anti-VEGF treatment. Continuous wave milipulse yellow laser 577 nm (CWMYL-577) has a high absorption peak for oxyhaemoglobin, which allows low power density use. Purpose: To report case PEVAC-like lesion unresponsive and corticosteroids, successfully treated with single session minimally invasive focal laser, using CWMYL-577....
<b><i>Aim:</i></b> Evaluate the real-life experience with ocriplasmin on vitreomacular traction (VMT) release and full-thickness macular hole (FTMH) closure in Portugal. <b><i>Methods:</i></b> Multicentric, retrospective study of 83 eyes 78 patients who were treated intravitreal for VMT without FTMH. Primary outcomes FTMH closure. Secondary included visual acuity changes structural features spectral-domain ocular coherence tomography....
Introdução: Apesar dos recentes avanços no tratamento da degenerescência macular idade (DMI) neovascular (nDMI), a falta de opções terapêuticas para as formas não avançadas (cerca 90%) e atróficas (Corradetti et al., 2021) reforça necessidade identificar potenciais biomarcadores como estratégia saúde pública. (More, Almuhtaseb, Smith, Fraser, & Lotery, 2019) A abordagem multimodal, com o apoio histologia, tem sido importante na procura AMD. Fatores genéticos têm também considerados...