A5064675768- Retinal Diseases and Treatments
- Retinal Development and Disorders
- Retinal Imaging and Analysis
- Retinal and Optic Conditions
- Advanced MRI Techniques and Applications
- Advanced Neuroimaging Techniques and Applications
- Glaucoma and retinal disorders
- Visual perception and processing mechanisms
- Photoreceptor and optogenetics research
- Ophthalmology and Visual Impairment Studies
- Acute Ischemic Stroke Management
- Neurological and metabolic disorders
- Optical Imaging and Spectroscopy Techniques
- Functional Brain Connectivity Studies
- Barrier Structure and Function Studies
- Corneal surgery and disorders
- Cardiovascular Health and Disease Prevention
- Circadian rhythm and melatonin
- Drug-Induced Ocular Toxicity
- Intraocular Surgery and Lenses
- Mitochondrial Function and Pathology
- Biochemical effects in animals
- Neuroscience and Neuropharmacology Research
Centro Hospitalar de Lisboa Central
2025
University of Coimbra
2012-2020
Association for Innovation and Biomedical Research on Light and Image
2014
Background/Objectives: Age-related macular degeneration (AMD) is a global cause of vision loss, with limited therapeutic options highlighting the need for effective biomarkers. This study aimed to characterize plasma DNA methyltransferase expression (DNMT1, DNMT3A, and DNMT3B) in AMD patients explore divergent patterns across different stages AMD. Methods: Thirty-eight were prospectively enrolled stratified by disease severity: eAMD, iAMD, nAMD, aAMD. Comprehensive ophthalmological...
Type 2 diabetes (T2DM) patients develop vascular complications and have increased risk for neurophysiological impairment. Vascular pathophysiology may alter the blood flow regulation in cerebral microvasculature, affecting neurovascular coupling. Reduced fMRI signal can result from decreased neuronal activation or disrupted The uncertainty about pathophysiological mechanisms (neurodegenerative, vascular, both) underlying brain function impairments remains. In this cross-sectional study, we...
Human studies addressing the long-term effects of peripheral retinal degeneration on visual cortical function and structure are scarce. Here we investigated this question in patients with Retinitis Pigmentosa (RP), a genetic condition leading to degeneration. We acquired functional anatomical magnetic resonance data from thirteen different levels loss twenty-two healthy participants study primary (V1) retinotopic remapping thickness. identified systematic field absence structural changes...
Retinitis Pigmentosa is a group of hereditary retinal dystrophy disorders associated with progressive peripheral visual field loss. The impact this loss in cortical gray matter volume has not been addressed before patients low vision. Voxel-based morphometry was applied to study whole brain changes 27 partially preserved vision and 38 age- gender-matched normally sighted controls determine whether can lead volume. We found significant reductions that were restricted the occipital cortex...
Glucose metabolism is pivotal for energy and neurotransmitter synthesis homeostasis, particularly in Glutamate GABA systems. In turn, the stringent control of inhibitory/excitatory tonus known to be relevant neuropsychiatric conditions. Glutamatergic neurotransmission dominates excitatory synaptic functions involved plasticity excitotoxicity. GABAergic neurochemistry underlies inhibition predicts impaired psychophysical function diabetes. It has also been associated with cognitive decline...
To quantitatively evaluate visual function 12 months after bilateral implantation of the Physiol FineVision® trifocal intraocular lens (IOL) and to compare these results with those obtained in first postoperative month.In this prospective case series, 20 eyes 10 consecutive patients were included. Monocular binocular, uncorrected corrected acuities (distance, near, intermediate) measured. Metrovision® was used test contrast sensitivity under static dynamic conditions, both photopic...
Abstract Blood‐brain barrier ( BBB ) permeability in type 2 diabetic patients has been previously shown to be altered certain brain regions such as the basal ganglia and hippocampus. Because of histological functional similarities between blood‐retinal BRB ), we aimed investigate how both barriers predicts visual outcome. We included control groups (acute unilateral stroke patients, n = 9; diabetics without leakage 10) a case study group with established (n 17). evaluated sex, age, disease...
It has remained a mystery why some genetic mitochondrial disorders affect predominantly specific cell types such as the retinal ganglion cell. This is particularly intriguing concerning and cortical function since they are tightly linked in health disease. Autosomal dominant optic neuropathy (ADOA) disease that affects However, it unknown whether alterations also present visual cortex, namely excitation/inhibition balance.In this study, we performed vivo structural biochemical proton...
The role of attentional mechanisms in peripheral vision loss remains an outstanding question. Our study was aimed at determining the effect genetically determined retinal dystrophy caused by Retinitis Pigmentosa (RP) on visual cortical function and tested recruitment using functional magnetic resonance imaging (fMRI). We included thirteen patients twenty-two age- gender-matched controls. analyzed responses under demands passive viewing conditions while presenting a stimulus covering central...
Purpose Retinitis Pigmentosa (RP) is a rare retinal disease with progressive degeneration of photoreceptors leading to early peripheral and later central visual loss. It provides model analyze cortex plasticity since onset age ranges from infancy adulthood. Prior studies have mostly covered structural or functional alterations in the same cohort; hence we aimed determine impact RP on brain function structure using magnetic resonance imaging. Methods Brain images 5 subjects (age 37-66 years,...
Cardiovascular disease and diabetes represent a major public health concern. The former is the most frequent cause of death disability in patients with type 2 diabetes, where left ventricular dysfunction highly prevalent. Moreover, diabetic retinopathy becoming dominant visual impairment blindness. complex relation between cardiovascular as function ageing, obesity hypertension remains to be clarified. Here, we investigated such relations 2, subjects neither overt heart nor advanced...
Purpose To assess visual impairment in diabetic patients with and without established blood-retinal barrier leakage relation the status of blood-brain barrier. Methods We assessed 37 (29 type2; mean Hb1Ac 7.93[1.44]) using four different approaches: a two-alternative forced-choice multi-psychophysical channel test for speed discrimination achromatic contrast as well chromatic L, M S cone discrimination; multifocal electrorretinography(mfERG) brain integrity assessment permeability measure...
Purpose Retinitis Pigmentosa (RP) is a retinal disease characterized by photoreceptor degeneration. Usually, symptoms are early onset night blindness followed progressive peripheral vision loss, with central being later affected. Some patients become blind after several years of disease. We studied the consequences this loss visual input in human brain using Magnetic Resonance Imaging. Methods 13 RP (8M, 5F; mean age 47±13yrs; range:23-66yrs) and 24 age-matched controls (10M, 14F; 44±13yrs;...
Purpose Studies concerning the effects of peripheral retinal degeneration on visual cortical structure and function are scarce. Our work aimed to determine effect dystrophy caused by Retinitis Pigmentosa brain using magnetic resonance imaging, taking into account preserved field extent disease onset age. Methods We included thirteen patients twenty-two matched controls. analyzed responses under attentional demands passive viewing conditions while presenting a stimulus covering central...