A5060475233- Metal complexes synthesis and properties
- X-ray Diffraction in Crystallography
- Crystallization and Solubility Studies
- Ferrocene Chemistry and Applications
- Click Chemistry and Applications
- Research on Leishmaniasis Studies
- Organometallic Compounds Synthesis and Characterization
- Synthesis and biological activity
- Atomic and Molecular Physics
- Magnetism in coordination complexes
- Advanced Chemical Physics Studies
- Synthesis and Characterization of Heterocyclic Compounds
- Synthesis and Biological Evaluation
- Organometallic Complex Synthesis and Catalysis
- Porphyrin and Phthalocyanine Chemistry
- N-Heterocyclic Carbenes in Organic and Inorganic Chemistry
- Inorganic and Organometallic Chemistry
- Trypanosoma species research and implications
- Nanoparticle-Based Drug Delivery
- Photodynamic Therapy Research Studies
- Lanthanide and Transition Metal Complexes
- Protein Interaction Studies and Fluorescence Analysis
- Advanced biosensing and bioanalysis techniques
- Electron and X-Ray Spectroscopy Techniques
- Healthcare and Environmental Waste Management
Universidade Federal de Minas Gerais
2016-2025
Universidade Federal de Juiz de Fora
2005-2019
Virginia Commonwealth University
2011-2012
In-Q-Tel
2012
The drugs currently used to treat leishmaniases have limitations concerning cost, efficacy, and safety, making the search for new therapeutic approaches urgent. We found that gold(I)-derived complexes were active against L. infantum braziliensis intracellular amastigotes with IC50 values ranging from 0.5 5.5 μM. All gold(I) potent inhibitors of trypanothione reductase (TR), enzyme 1 7.8 Triethylphosphine-derived enhanced reactive oxygen species (ROS) production decreased mitochondrial...
Cancer is one of the main challenges global public health and a leading cause death, hindering increase in life expectancy, Leishmaniasis occupies second position number deaths from parasitic diseases. Gold(I)‐based drugs are being studied for chemotherapy have been shown promising results, to search analogs with more favorable effect profiles. This work presents synthesis characterization five new gold(I) complexes, [AuIDTCPPh3] [AuI2DTC(PPh3)2], using dithiocarbamate‐derived ligands...
Measured and calculated differential cross sections for elastic (rotationally unresolved) electron scattering from two primary alcohols, methanol $(\mathrm{C}{\mathrm{H}}_{3}\mathrm{O}\mathrm{H})$ ethanol $({\mathrm{C}}_{2}{\mathrm{H}}_{5}\mathrm{O}\mathrm{H})$, are reported. The measurements obtained using the relative flow method with helium as standard gas a thin aperture collimating target source. is applied without restriction imposed by pressure conditions on unknown gas. experimental...
We examined the mechanism of accumulation charged polynuclear platinum complexes (PPCs) based on analogy polyarginine interactions with cell surface heparan sulfate proteoglycan (HSPG) family protein-linked glycosoaminoglycan polysaccharides (GAGs). GAGS such as (HS) and chondroitin (CS) mediate cellular entry many molecules. Fluorescence microscopy flow cytometry showed that PPCs, but not neutral cisplatin or oxaliplatin, blocked TAMRA-R9 (a nonarginine peptide, R9) coupled to TAMRA...
Differential cross sections for elastic electron scattering from gaseous water are reported. The measurements obtained using the relative flow method with He as standard gas and a thin collimating aperture source of instead conventional needle source. were measured at incident energies 1, 2, 4, 6, 8, 10, 15, 20, 30, 50, $100\phantom{\rule{0.3em}{0ex}}\mathrm{eV}$ angles ranging 5\ifmmode^\circ\else\textdegree\fi{} to 130\ifmmode^\circ\else\textdegree\fi{} integrated over obtain integral...
Platinum(II) and palladium(II) complexes [ML2] have been isolated from reaction of K2PtCl4 or K2PdCl4 ligands (L) derived thiosemicarbazones. The were characterized by elemental analysis, Raman, IR, NMR spectroscopy. In addition, quantum mechanical calculations used to predict their structures spectroscopic properties. For the first time, theoretical using 195Pt data support suggested structures. results indicate that thionic sulfur azomethine nitrogen are bonded metal ion in a trans...
We report measured and calculated cross sections for elastic scattering of low-energy electrons by the alcohols $n$-propanol $n$-butanol in gas phase. The measurements were carried out using relative-flow method with an aperture source rather than a conventional tube or capillary-array source, eliminating need to know molecular diameters. calculations employed two different implementations Schwinger multichannel variational included polarization effects. differential are dominated strong...
It has been reported recently that SbIII competes with ZnII for its binding to the CCHC zinc finger domain of HIV-1 NCp7 protein, suggesting proteins may be molecular targets antimony-based drugs. Here, interaction a CCCH domain, which is considered play crucial role in biology kinetoplastid protozoa, characterized first time. The characteristics were compared between CCCH-type peptide derived from protein and two different CCHC-type peptides. formation 1 : Zn–peptide Sb–peptide complexes...
Four gold(I) complexes conceived as anticancer agents were synthesized by reacting [Au(PEt3 )Cl] and [Au(PPh3 with ligands derived from δ-d-gluconolactone. The ligands' structure was designed to combine desired biological properties previously reported for each group. Ligands δ-d-gluconolactone via ketal protection hydrazide formation followed cyclization CS2 produce the novel oxadiazolidine-2-thione 7 8. Increasing of lipophilicity proved useful since all four showed antileishmanial...