A5088437652- Essential Oils and Antimicrobial Activity
- Sesquiterpenes and Asteraceae Studies
- Plant Toxicity and Pharmacological Properties
- Phytochemistry Medicinal Plant Applications
- Natural product bioactivities and synthesis
- Carcinogens and Genotoxicity Assessment
- Bee Products Chemical Analysis
- Psidium guajava Extracts and Applications
- Insect Pest Control Strategies
- Plant-derived Lignans Synthesis and Bioactivity
- Insect and Pesticide Research
- Phytochemistry and Biological Activities
- Plant tissue culture and regeneration
- Traditional and Medicinal Uses of Annonaceae
- Agricultural and Food Sciences
- Potato Plant Research
- Marine Sponges and Natural Products
- Sesame and Sesamin Research
- Advances in Cucurbitaceae Research
- Phytochemicals and Antioxidant Activities
- Ocular Surface and Contact Lens
- Nanoparticle-Based Drug Delivery
- Insect behavior and control techniques
- Synthesis and Biological Evaluation
- Advanced Drug Delivery Systems
Universidade de Franca
2016-2025
Universidade de São Paulo
2011-2015
Universidade dos Açores
2014
University of Arizona
2013
Fundação de Amparo à Pesquisa do Estado de São Paulo
2013
Fundação Getulio Vargas
2010
This study evaluated the antibacterial and antiproliferative activities of essential oil Psidium guajava leaves (PG-EO), traditionally used in folk medicine. The was obtained from fresh by hydrodistillation, using a modified Clevenger apparatus. major PG-EO chemical constituents were identified GC-MS GC-FID as being β-caryophyllene (16.1%), α-humulene (11.9%), aromadendrene oxide (14.7%), δ-selinene (13.6%), selin-11-en-4α-ol (12.5%). activity P. determined terms its minimum inhibitory...
Ursolic acid (UA) and oleanolic (OA) are pentacyclic triterpenoid compounds found in plants used the human diet medicinal herbs, form of aglycones or as free acid. These known for their hepatoprotective, anti-inflammatory, antimicrobial, hypoglycemic, antimutagenic, antioxidant, antifertility activities. In present study, we evaluated effects UA OA on formation 1,2-dimethyl-hydrazine (DMH)–induced aberrant crypt foci (ACF) colon male Wistar rat. The animals received subcutaneous (sc)...
Abstract Rosmarinic acid (RA) is a naturally occurring phenolic compound, which contributes to the beneficial and health‐promoting effects of herbs, spices medicinal plants. RA has shown several biological activities, such as hepatoprotective, anti‐inflammatory, antiangiogenic, antitumor, antidepressant, antineurodegenerative, HIV‐1 inhibitory antioxidant effects. The aim this study was investigate ability prevent chemically induced chromosome breakage or loss primary DNA damage using...
Context: Despite several pharmacological applications of Rosmarinus officinalis L. (Lamiaceae), studies on its analgesic and anti-inflammatory properties have been scarce.Objective: The aim this work was to use in vivo models evaluate the activities aqueous extracts obtained from leaves (AEL) stems (AES) officinalis, as well isolated compound – rosmarinic acid (RA). We also prepared assessed acetyl ester derivative RA.Materials methods: activity evaluated using abdominal constriction...
The Brazilian Caatinga green propolis (GP) is known for its significant biological activities; however, incorporation into pharmaceutical formulations hindered by resinous nature and low solubility. This study investigates the analgesic anti-inflammatory effects of both free GP nanoencapsulated (GPN). optimized oil/water nanoformulation maintained stability over a period 28 days, exhibiting minimal alterations in particle size (approximately 200 nm) polydispersity index. GPN demonstrated...
In this study, the chemical composition and antibacterial antiproliferative potential of essential oil obtained from fresh leaves Psidium myrtoides (PM-EO) against oral pathogens human tumour cell lines were investigated for first time. GC-FID GC-MS analyses showed that trans-β-caryophyllene (30.9%), α-humulene (15.9%), α-copaene (7.8%), caryophyllene oxide (7.3%) α-bisabolol (5.3%) are major constituents PM-EO. The activity PM-EO a panel was in terms their minimal inhibitory concentrations...
ABSTRACT Copaifera lansdorffii Desf. is known as ‘copaíba’, ‘copaiva’ or ‘paú‐de‐óleo’, and found in part of Brazil. The present study was undertaken to evaluate the genotoxic potential C . langsdorffii leaf hydroalcoholic extract (CLE) its influence on genotoxicity induced by chemotherapeutic agent doxorubicin (DXR) using Swiss mouse peripheral blood micronucleus test. HPLC analysis CLE two monolithic columns linked series allowed quantification major flavonoid heterosides, quercitrin...
Abstract Background Natural antioxidants present in common foods and beverages have drawn great attention to cancer prevention due its health benefits, remarkable lack of toxicity side effects. Copaifera langsdorffii , known as “copaiba”, “capaiva”, or “pau-de-óleo“, belongs the Leguminosae family occurs fields grasslands northern northeastern parts Brazil. Biological studies corroborate widespread use by population. This paper describes effects C. leaves hydroalcoholic extract on...
Rosmarinic acid (RA) is a polyphenolic compound that shows number of interesting biological activities, such as antiapoptotic, antifibrotic, antioxidant, hepatoprotective, antineurodegenerative, and anti-inflammatory properties. The aim this study was to investigate the ability RA prevent 1,2-dimethylhydrazine (DMH)-induced primary DNA damage aberrant crypt foci (ACF) in Wistar rat colon. animals were treated by gavage with doses 4, 8, 16 mg/kg body weight/day. Next, received single...
Abstract Essential oils, which may be extracted from several parts of plants, have different biological activities. The Brazilian Cerrado has a large variety plants that yield essential even though many not been studied yet. Taking into account the biodiversity this biome, study aimed at evaluating antiproliferative activity oils three species in Goiás state: Campomanesia adamantium (Cambess.) O. Berg, Protium ovatum (Engl. Mart.) and Cardiopetalum calophyllum (Schltdl.). were both C. leaves...
The unique properties of macroporous, mesoporous, and microporous systems, including their ability to accommodate molecules different sizes inside pores act as drug delivery have been the object extensive studies. In this work, mesoporous silica with hexagonal structure was obtained by template synthesis via sol-gel process. resulting material used support anti-inflammatory agent indomethacin. alkaline route prepare silica; cetyltrimethylammonium bromide employed porogenic agent. particles...
In Brazilian folk medicine, copaiba oleoresin is widely known for its therapeutic activity, especially wound healing and anti-inflammatory actions. Considering the relationship between inflammatory processes carcinogenesis, this paper reports on Copaifera reticulata Ducke (CRO) chemopreventive potential in colon carcinogenesis model rats. To understand mechanisms involved effect, activity of CRO major chemical constituent, diterpene ent-polyalthic acid (PA), were evaluated production nitric...
The oral cavity, which harbors more than 750 bacterial species, is one of the most diverse sites human body. Some these bacteria have been associated with diseases, such as dental caries and endodontic infections. We report on antimicrobial cytotoxic activities Copaifera oblongifolia oleoresin against that cause aim this study to determine minimum (MIC) bactericidal (MBC) inhibitory concentrations well biofilm inhibition ability (through determination MBIC50) C. oleoresin. This also...
Despite reports on the pharmacological potential of Copaifera langsdorffii Desf. (Leguminosae-Caesalpinioideae) leaf extract, little is known about its chemical composition. In this work, a phytochemical study from C. ethanol/H2O 7:3 (v/v) extract was undertaken. Separation performed by high-speed counter-current (HSCCC) and Sephadex LH-20 column chromatographies, followed preparative HPLC. The EtOAc- H2O-soluble fractions furnished flavonoids quercitrin (1) afzelin (2)...
This study aimed at evaluating the potential of Copaifera lucens, specifically its oleoresin (CLO), extract (CECL), and compound ent-polyalthic acid (PA), in combating caries toxoplasmosis, while also assessing toxicity. The involved multiple assessments, including determining minimum inhibitory concentration (MIC) bactericidal (MBC) against cariogenic bacteria. CLO PA exhibited MIC MBC values ranging from 25 to 50 μg/mL, whereas CECL showed equal or exceeding 400 μg/mL. displayed...
ABSTRACT Artepillin C (3,5‐diprenyl‐ p ‐coumaric acid), a major compound found in Brazilian green propolis and Baccharis dracunculifolia , shows anti‐inflammatory, antibacterial, antiviral, antioxidant antitumoral activities, among others. The aim of this study was to evaluate the genotoxic potential artepillin its ability prevent chemically induced chromosome breakage or loss primary DNA damage using micronucleus comet assays male Swiss mice, respectively. animals were treated by gavage...