A5057149624- MicroRNA in disease regulation
- Cancer-related molecular mechanisms research
- Carcinogens and Genotoxicity Assessment
- Essential Oils and Antimicrobial Activity
- Bee Products Chemical Analysis
- Healthcare Regulation
- Plant Toxicity and Pharmacological Properties
- Science and Education Research
- Phytochemistry Medicinal Plant Applications
- Potato Plant Research
- Palliative and Oncologic Care
- Cassava research and cyanide
- Pluripotent Stem Cells Research
- CRISPR and Genetic Engineering
- Circular RNAs in diseases
- Electrospun Nanofibers in Biomedical Applications
- Education during COVID-19 pandemic
- Sesquiterpenes and Asteraceae Studies
- Single-cell and spatial transcriptomics
- Mesenchymal stem cell research
- Global Cancer Incidence and Screening
- Maternal and Neonatal Healthcare
- Signaling Pathways in Disease
- Bioactive Compounds and Antitumor Agents
- Radiation Dose and Imaging
Universidade Federal do Acre
2020-2024
Universidade de Franca
2011-2021
Universidade Federal do Rio de Janeiro
2021
Universidade de São Paulo
2019
Clinics Hospital of Ribeirão Preto
2019
SUPERA Park of Innovation and Technology of Ribeirão Preto
2018
Solanum lycocarpum St.-Hil (Solanaceae) is a hairy shrub or small much-branched tree of the Brazilian Cerrado, popularly known as "fruit-of-wolf". Considering that induction chromosomal mutations involved in process carcinogenesis, and S. often used folk medicine, it becomes relevant to study its effect on genetic material. In this sense, aim present was determine possible cytotoxic, genotoxic antigenotoxic potentials fruits glycoalkaloid extract (SL) Chinese hamster lung fibroblasts (V79...
Abstract Background Natural antioxidants present in common foods and beverages have drawn great attention to cancer prevention due its health benefits, remarkable lack of toxicity side effects. Copaifera langsdorffii , known as “copaiba”, “capaiva”, or “pau-de-óleo“, belongs the Leguminosae family occurs fields grasslands northern northeastern parts Brazil. Biological studies corroborate widespread use by population. This paper describes effects C. leaves hydroalcoholic extract on...
This study evaluated the antiproliferative activity of Brazilian green propolis and <i>Baccharis dracunculifolia</i> extracts their major compounds artepillin C baccharin in different tumor cell lines. The lowest IC<sub>50</sub> values observed for <i>B. were 41.0 ± 4.5 µg/mL U343 44.9 7.1 HepG2, respectively. Regarding baccharin, 20.1 2.9 13.0 1.5 B16F10, For association plus result was 35.2 0.5 B16F10. Artepillin more cytotoxic than both extracts. No additive or synergistic effect baccharin.
ABSTRACT Artepillin C (3,5‐diprenyl‐ p ‐coumaric acid), a major compound found in Brazilian green propolis and Baccharis dracunculifolia , shows anti‐inflammatory, antibacterial, antiviral, antioxidant antitumoral activities, among others. The aim of this study was to evaluate the genotoxic potential artepillin its ability prevent chemically induced chromosome breakage or loss primary DNA damage using micronucleus comet assays male Swiss mice, respectively. animals were treated by gavage...
By post-transcriptionally regulating multiple target transcripts, microRNAs (miRNAs or miR) play important biological functions. H1 embryonic stem cells (hESCs) and NTera-2 embryonal carcinoma (ECCs) are two of the most widely used human pluripotent model cell lines, sharing several characteristics, including expression miRNAs associated to state with differentiation. However, how each these functionally impacts properties has not been systematically evaluated. We investigated effects 31 on...
Colorectal cancer (CRC) is still a leading cause of death worldwide. Recent studies have pointed to an important role microRNAs in carcinogenesis. Several are described as aberrantly expressed CRC tissues and the serum patients. However, functional outcomes microRNA aberrant expression need be explored at cellular level. Here, we aimed investigate effects samples proliferation cell line.We transfected 31 mimics into HCT116 cells. Total number live propidium iodide negative (PI-) dead (PI+)...
Artepillin C (3,5-diprenyl-p-coumaric acid) is one of the major phenolic compounds found in Brazilian green propolis, as well its botanical source, Baccharis dracunculifolia DC (Asteraceae). The present study evaluated possible genotoxic and protective activities artepillin C, vitro, using methyl methanesulfonate (MMS) a positive control, by comet micronucleus assays. cultures Chinese hamster lung fibroblasts (V79 cells) were treated with different concentrations (2.5, 5.0, 10.0, 20 μM). In...
Head and neck squamous cell carcinoma (HNSCC) is among the most common cancer types. Metastasis, main cause of death by cancer, can be promoted an inflammatory microenvironment, which induces epithelial-mesenchymal transition (EMT) through a NF-kB-mediated stabilization Snail. Here, we aimed to explore how microRNAs (miRs) affect survival EMT in HNSCC cells under microenvironment. By using high-content screening (HCS) approach, evaluated alterations morphometric parameters, as well...
Copaifera langsdorffii Desf. is a plant found in South America, especially Brazil. Oleoresin and the leaves of this used as popular medicinal agent. However, few studies on chemical composition aerial parts related biological activities are known. This study aimed to examine cytotoxic, genotoxic, antigenotoxic potential C. hydroalcoholic extract (CLE) two its major compounds afzelin quercitrin. The cytotoxic CLE was determined follows: 1) against genotoxicity induced by doxorubicin (DXR) or...
Betulinic acid (BA) is a pentacyclic triterpene that can be isolated from many medicinal plants around the world. The aim of this study was to evaluate genotoxic potential BA and its effect on genotoxicity induced by different mutagens in V79 cells using cytokinesis-block micronucleus assay. Different concentrations were combined with methyl methanesulfonate (MMS), doxorubicin (DXR), camptothecin (CPT), etoposide (VP-16). frequencies micronuclei cultures treated did not differ those negative...
<title>Abstract</title> HDV is associated with the worst prognosis of viral hepatitis and there a considerable lack testing for in patients. <italic>Phage display</italic> was used to select mimetic peptides through biopanning, followed by DNA sequencing phage-ELISA. Based on sequences selected peptides, we constructed recombinant protein (rHDV) use an Enzyme-Linked Immunosorbent Assay (ELISA). We validated test 87 samples (anti-HDV+) 93 HBV controls collected from public diagnosis...
Introduction: This study aimed to evaluate the use of sodium bicarbonate solution as an adjunct in treatment critically ill patients intensive care unit (ICU). Methods: A group 76 were followed up, which 44 received with a (NaHCO3) along conventional treatment, and 32 used only treatment. Results: In treated, there was improvement radiological findings, decrease opacity bilateral consolidations, well reduced length stay ICU, mortality. Conclusion: The NaHCO3 COVID-19 improved prognosis compared
Matrix metalloproteinases (MMPs) are enzymes that present a metallic element in their structure. These ubiquitously distributed and function as extracellular matrix (ECM) remodelers. MMPs play broad role cardiovascular biology regulating processes such cell adhesion function, cellular communication differentiation, integration of mechanical force transmission, tissue remodeling, modulation damaged-tissue structural integrity, survival or apoptosis regulation inflammation-related cytokines...
A terapia fotodinâmica (TFD) é um procedimento muito promissor para uma variedade de tumores sólidos e lesões malignas por demonstrar eficácia terapêutica in vitro vivo. Deste modo, foi realizado pesquisa descritiva exploratória, com análise bibliográfica não exaustiva dos últimos 6 (seis) anos, (2015 a 2021) em língua portuguesa inglesa. Dentre os 50 artigos analisados, 16 demonstrado que TFD potencial aliado no tratamento células tumorais, vez que, houve o aumento efeito antitumoral...
Solanum lycocarpum A. St.-Hil. (Solanaceae) are commonly used in traditional medicine for the treatment of diabetes and obesity, as well controlling cholesterol levels. Solasonine solamargine two major glycoalkaloids found at least 100 species. In this sense, aim present study was to evaluate cytotoxic, genotoxic antigenotoxic potential S. fruits glycoalkaloid extract (SL), (SM) solasonine (SS), V79 cells. Cytotoxicity evaluated by colony forming assay. Genotoxic were comet Different...
Abstract Like many solid cancers, in head and neck cancers (HNC) the presence of metastases is a well-known prognostic factor associated with worst survival. Studies to date indicate that chronic stimulation tumor necrosis alpha (TNF-α) has potential enhance several cell characteristics, such as survival, proliferation, migration, promoting metastasis. It believed TNF-α leads activation different inflammatory pathways, nuclear factor-kappa B (NF-kB) AKT pathway, inhibiting GSK-3β-mediated...