A5019176314- Heavy Metal Exposure and Toxicity
- Selenium in Biological Systems
- Venomous Animal Envenomation and Studies
- Mercury impact and mitigation studies
- Peptidase Inhibition and Analysis
- Blood Coagulation and Thrombosis Mechanisms
- Protease and Inhibitor Mechanisms
- Signaling Pathways in Disease
- Coagulation, Bradykinin, Polyphosphates, and Angioedema
Universidade Federal do Pará
2019-2022
Matrix metalloproteinases (MMPs) are enzymes that present a metallic element in their structure. These ubiquitously distributed and function as extracellular matrix (ECM) remodelers. MMPs play broad role cardiovascular biology regulating processes such cell adhesion function, cellular communication differentiation, integration of mechanical force transmission, tissue remodeling, modulation damaged-tissue structural integrity, survival or apoptosis regulation inflammation-related cytokines...
BmooMPα-I has kininogenase activity, cleaving kininogen releasing bradykinin and can hydrolyze angiotensin I at post-proline aspartic acid positions, generating an inactive peptide. We evaluated the antihypertensive activity of in a model two-kidney, one-clip (2K1C). Wistar rats were divided into groups: Sham, who underwent sham surgery, 2K1C, suffered stenosis right renal artery. In second week hypertension, we started treatment (Vehicle, Losartan) for two weeks. performed electrocardiogram...