A5026956921- Tannin, Tannase and Anticancer Activities
- Nanoplatforms for cancer theranostics
- Natural product bioactivities and synthesis
- Plant-derived Lignans Synthesis and Bioactivity
- Potato Plant Research
- Sesquiterpenes and Asteraceae Studies
- Carcinogens and Genotoxicity Assessment
- Essential Oils and Antimicrobial Activity
- Genomics, phytochemicals, and oxidative stress
- Bioactive Compounds and Antitumor Agents
- 3D Printing in Biomedical Research
- Cancer Cells and Metastasis
- Phytochemistry and Biological Activities
- Cassava research and cyanide
- Plant Toxicity and Pharmacological Properties
- Antimicrobial agents and applications
- Electrospun Nanofibers in Biomedical Applications
- DNA and Nucleic Acid Chemistry
- Proteoglycans and glycosaminoglycans research
- Polymer Surface Interaction Studies
- Cancer, Stress, Anesthesia, and Immune Response
- Radiopharmaceutical Chemistry and Applications
- Phytochemistry Medicinal Plant Applications
- Photodynamic Therapy Research Studies
- Luminescence and Fluorescent Materials
Centre National de la Recherche Scientifique
2022-2023
Nantes Université
2022-2023
Université d'Angers
2022-2023
Inserm
2022-2023
Centre de Recherche en Cancérologie et Immunologie Intégrée Nantes Angers
2022-2023
Universidade de Franca
2013-2022
Many studies have reported that medicinal plant extracts can inhibit oral pathogen growth or adhesion to surfaces and therefore reduce dental caries formation. The addition of these products like mouthwashes dentifrices is considered an important strategy in control. In this sense, we developed a Mikania glomerata extract with high ent-kaurenoic acid content (KAMg). So, work describes the preparation such development validated HPLC-DAD method determine its (KA) content. Herein it also...
The fruits of Solanum lycocarpum, known as wolf-fruit, are used in folk medicine, and because that we have evaluated both the genotoxic potential its glycoalkaloidic extract (SL) influence on genotoxicity induced by methyl methanesulfonate. Furthermore, blocking effect SL intake initial stage colon carcinogenesis Wistar rats was investigated a short-term (4-week) bioassay using aberrant crypt foci (ACF) biomarker. Swiss mice peripheral blood micronucleus test. animals were treated with...
Considering the impact of dental caries on public health and wide biological potential described for species belonging to genus Pinus, here we investigate antibacterial activity P. elliottii tropicalis resins diterpene dehydroabietic acid (DHA) against cariogenic bacteria. For this purpose, have determined minimum inhibitory concentration (MIC) bactericidal (MBC) diterpene. We also investigated biofilm inhibition ability (through MBIC50 determination), as well synergistic effect fractional...
(-)-Cubebin (CUB) is a lignan isolated from dry seeds of Piper cubeba. We aimed to assess its genotoxic potential and influence on chromosomal damage (frequency micronuclei - MN) induced by doxorubicin (DXR) in V79 cells urethane (URE) somatic Drosophila melanogaster cells. Our findings indicate an absence CUB-mediated effect at the concentrations tested. The results also revealed that CUB significantly reduced frequency MN DXR, with mean reduction 63.88%. In previous study, our research...
In view of inevitable recurrences despite resection, glioblastoma (GB) is still an unmet clinical need. Dealing with the stromal-cell derived factor 1-alpha (SDF-1α)/CXCR4 axis as a hallmark infiltrative GB tumors and resection cavity situation, present study described effects relevance new engineered micro-nanostructured SF-HA-Hep aerogel sponges, made silk fibroin (SF), hyaluronic acid (HA) heparin (Hep) loaded SDF-1α, to interfere ecosystem residual cells, attracting confining them in...
Melanoma is the most aggressive type of skin cancer, and thus it important to develop new drugs for its treatment. The present study aimed examine antitumor effects solamargine a major alkaloid heteroside in Solanum lycocarpum fruit. In addition was incorporated into nanoparticles (NP) yttrium vanadate functionalized with 3-chloropropyltrimethoxysilane (YVO4:Eu3+:CPTES:SM) determine activity. anti-melanoma assessment performed using syngeneic mouse melanoma model B16F10 cell line. addition,...
The aim of this study was to examine the cytotoxic and genotoxic potential a hydroethanolic extract Schefflera vinosa (SV), plant with schistosomicidal activity, as well its influence on DNA damage induced by different mutagens, methyl methane sulfonate (MMS) hydrogen peroxide (H2O2), in V79 cells Swiss mice. produced cytotoxicity at concentrations 312.5 µg/ml or higher using XTT cell proliferation assay kit. Treatment cultures highest SV concentration tested (150 µg/ml) significantly...
Phytochemicals have been suggested as an effective strategy for cancer prevention. Within this context, triterpene betulinic acid (BA) exhibits several biological properties but its chemopreventive effect has not fully demonstrated. The present study investigated the antigenotoxic potential of BA against doxorubicin (DXR)-induced genotoxicity using mouse peripheral blood micronucleus assay, well anticarcinogenic activity 1,2dimethylhydrazine (DMH)-induced colorectal lesions in rats....
(2021). Styrax camporum, a typical species of the Brazilian cerrado, attenuates DNA damage, preneoplastic lesions and oxidative stress in experimental rat colon carcinogenesis. Journal Toxicology Environmental Health, Part A: Vol. 84, No. 14, pp. 582-592.
Abstract. Ferreira NH, Ribeiro AB, Morais MD, Peixoto AM, Bernardino MA, Moreira MR, Soares ACF, Heleno VCG, Veneziani RCS, Tavares DC. 2018. Cytotoxic and genotoxic effects of the ent-kaurenoic acid acid-enriched Mikania glomerata extract in V79. Biofarmasi J Nat Prod Biochem 17: xxxx. The acid-rich from Sprengel was effective to inhibit formation Streptococcus mutans biofilm. In view biological potential this its major component, present study carried out evaluate safety alone an vitro...
O câncer de pele, devido a exposicao em excesso radiacao ultravioleta do sol, e muito comum no Brasil, correspondendo 25% dos tumores malignos diagnosticados. Atualmente, pesquisadores tem procurado tratamentos mais eficazes para curar pacientes com câncer. A cis-diaminodicloroplatina(II) (cisplatina) o principal composto utilizado na quimioterapia anti-câncer. Estima-se que 50-70% todo mundo usam esta droga, entanto ela apresenta inumeros efeitos colaterais pode afetar adversamente os rins,...
Purpose: The Styrax genus belongs to the Styracaceae family and includes about 130 species. produces a resinous material, resin of benzoin, which is secreted when sharp objects hurt bark. In traditional medicine, this employed as topical antiseptic, expectorant, in respiratory diseases an inhalant. Additionally, S. camporum used folk medicine treatment gastrointestinal diseases. Chemical studies from leaves barks extracts resulted isolation lignans, neolignans, triterpenes flavonoids. aims...