A5061185993- Essential Oils and Antimicrobial Activity
- Crystallization and Solubility Studies
- X-ray Diffraction in Crystallography
- Natural product bioactivities and synthesis
- Metal complexes synthesis and properties
- Bee Products Chemical Analysis
- Phytochemistry Medicinal Plant Applications
- Phytochemistry and Biological Activities
- Systemic Sclerosis and Related Diseases
- Plant Toxicity and Pharmacological Properties
- Crystal structures of chemical compounds
- Sesquiterpenes and Asteraceae Studies
- Bioactive Compounds and Antitumor Agents
- Psidium guajava Extracts and Applications
- Phytochemistry and biological activity of medicinal plants
- Antimicrobial Peptides and Activities
- Traditional and Medicinal Uses of Annonaceae
- Antibiotic Resistance in Bacteria
- Ethnobotanical and Medicinal Plants Studies
- Plant chemical constituents analysis
- Metal-Organic Frameworks: Synthesis and Applications
- Endodontics and Root Canal Treatments
- Pharmacological Effects of Natural Compounds
- Synthesis and biological activity
- Microbial Metabolites in Food Biotechnology
Universidade Federal de Uberlândia
2020-2025
Universidade de Rio Verde
2023
Instituto Federal de Educação, Ciência e Tecnologia do Triângulo Mineiro
2023
Universidade de Ribeirão Preto
2023
Universidade de São Paulo
2023
Hospital de São João
2022
Universidade de Franca
2018-2020
Hospitais da Universidade de Coimbra
2014-2019
University of Coimbra
2017
Universidade Católica Portuguesa
2017
Tooth decay is a major public health problem which affects large number of people in several countries. Even though more than 700 bacterial species have been detected the oral cavity, Streptococcus and Lactobacillus stand out as genera that cause tooth other periodontal diseases. In this study, essential oils from Citrus aurantifolia leaves (CL-EO) fruit peel (CP-EO) were obtained by hydrodistillation Clevenger-type apparatus whereas their chemical composition was analyzed gas...
Abstract Candida species have been responsible for a high number of invasive infections worldwide. In this sense, Rottlerin has demonstrated wide range pharmacological activities. Therefore, study aimed to evaluate the antifungal, antibiofilm and antivirulence activity in vitro against spp. its toxicity antifungal vivo. showed all yeasts evaluated, presenting Minimum Inhibitory Fungicidal Concentration (MIC MFC) values 7.81 > 1000 µg/mL. Futhermore, it was able significantly inhibit...
Abstract Studies based on medicinal plants have stood out as a complementary treatment intervention to type 2 Diabetes mellitus and its complications. Among the Brazilian plants, we highlight Cordiera sessilis (Vell.) Kuntze, in turn, has been studied several chemical biological studies due ethnopharmacological indications. Thus, this study aimed evaluate antimicrobial, antioxidant, antiglycation, digestive enzyme inhibition effects of fractions obtained from ethanolic extract stem bark C....
To investigate the ex vivo pro-inflammatory properties of classical and non-classical monocytes as well myeloid dendritic cells (mDCs) in systemic sclerosis (SSc) patients.Spontaneous production CXCL10, CCL4, CXCL8 IL-6 was intracellularly evaluated classical, Siglec-3-expressing mDCs from peripheral blood SSc patients healthy controls (HC) through flow cytometry. In addition, these cytokines determined upon toll-like receptor (TLR) 4 plus Interferon-γ (IFN-γ) stimulation.The frequency...
Abstract Xylella fastidiosa is a plant-pathogenic bacterium that lives inside host xylem vessels, where it forms biofilm which believed to be responsible for disrupting the passage of water and nutrients. Pectobacterium carotovorum Gram-negative plant-specific causes not only soft rot in various plant hosts, but also blackleg potato by cell wall degradation. Chagas disease, caused Trypanosoma cruzi, has been commonly treated with nifurtimox benzonidazole, two drugs cause several side...
The oral cavity, which harbors more than 750 bacterial species, is one of the most diverse sites human body. Some these bacteria have been associated with diseases, such as dental caries and endodontic infections. We report on antimicrobial cytotoxic activities Copaifera oblongifolia oleoresin against that cause aim this study to determine minimum (MIC) bactericidal (MBC) inhibitory concentrations well biofilm inhibition ability (through determination MBIC50) C. oleoresin. This also...
Considering our previous findings on the remarkable activity exhibited by cobalt(III) with 2-acetylpyridine-N(4)-R-thiosemicarbazone (Hatc-R) compounds against Mycobacterium tuberculosis, present study aimed to explored new structure features of complexes type [Co(atc--R)2]Cl, where R = methyl (Me, 1) or phenyl (Ph, 2) (13C NMR, high-resolution mass spectrometry, LC–MS/MS, fragmentation study) together its antibacterial and antiviral biological activities. The minimal inhibitory bactericidal...
The microorganisms that constitute the oral microbiome can cause diseases, including dental caries and endodontic infections. use of natural products could help to overcome bacterial resistance antimicrobials are currently employed in clinical therapy. This study assessed antimicrobial activity Copaifera pubiflora oleoresin compounds isolated from this resin against bacteria. minimum inhibitory concentration (MIC) bactericidal (MBC) assays provided values ranging 6.25 > 400 μg/mL for C. its...
This study aimed at evaluating the potential of Copaifera lucens, specifically its oleoresin (CLO), extract (CECL), and compound ent-polyalthic acid (PA), in combating caries toxoplasmosis, while also assessing toxicity. The involved multiple assessments, including determining minimum inhibitory concentration (MIC) bactericidal (MBC) against cariogenic bacteria. CLO PA exhibited MIC MBC values ranging from 25 to 50 μg/mL, whereas CECL showed equal or exceeding 400 μg/mL. displayed...
Helicobacter pylori is a Gram-negative, microaerophilic, curved-rod, flagellated bacterium commonly found in the stomach mucosa and associated with different gastrointestinal diseases. With high levels of prevalence worldwide, it has developed resistance to antibiotics used its therapy. Brazilian red propolis been studied due biological properties, literature, shown promising antibacterial activities. The aim this study was evaluate anti-H. from crude hydroalcoholic extract (CHEBRP). For...
In Brazilian folk medicine, Protium heptaphyllum is used to treat inflammatory conditions and hasten wound repair. This paper aims investigate the chemical composition in vitro antibacterial effects of essential oils (EOs) obtained from P. leaves ripe unripe fruits against a representative panel oral pathogens. The GC-FID GC-MS analysis revealed that major components determined were myrcene (59.0%), β-elemene (17.2%), limonene (12.9%), spathulenol (12.6%), α-cubebene (11.6%), germacrene D...
Abstract The main pathogen underlying citrus variegated chlorosis (CVC), a fruit disease, is Xylella fastidiosa , Gram‐negative s‐shaped bacterium that blocks water and nutrient circulation. Discovering new pesticides to combat CVC have become challenge. Research into essential oils (EOs) crucial because these substances can be potentially useful in pest control. This study aims determine minimum inhibitory concentrations (MIC), investigate biofilm inhibition capacities through MBIC 50...
Drug-resistant bacteria constitute a big barrier against current pharmacotherapy. Efforts are urgent to discover antibacterial drugs with novel chemical and biological features. Our work aimed at the synthesis, evaluation of effects, toxicity licochalcone C (LCC), naturally occurring chalcone. The synthetic route included six steps, affording 10% overall yield. LCC showed effects Gram-positive (MIC = 6.2–50.0 µg/mL), Mycobacterium species 36.2–125 Helicobacter pylori 25 µg/mL). inhibited...
Helicobacter pylori is associated with gastrointestinal diseases, and its treatment challenging due to antibiotic-resistant strains, necessitating alternative therapies. Brazilian red propolis (BRP), known for diverse bioactive compounds pharmaceutical properties, was investigated anti-H. activity, focusing on biofilm formation inhibition eradication. BRP tested against H. (ATCC 43526) using several assays: time-kill, nucleotide leakage, (determining the minimum inhibitory concentration of...