A5007393879- Mosquito-borne diseases and control
- Nail Diseases and Treatments
- Oral microbiology and periodontitis research
- Essential Oils and Antimicrobial Activity
- Bone Metabolism and Diseases
- Bone health and treatments
- Antimicrobial Peptides and Activities
- Viral Infections and Vectors
- Synthesis and biological activity
- Antifungal resistance and susceptibility
- Antimicrobial Resistance in Staphylococcus
- HIV/AIDS drug development and treatment
- Herbal Medicine Research Studies
- Malaria Research and Control
- Insect symbiosis and bacterial influences
- Reproductive System and Pregnancy
- Photodynamic Therapy Research Studies
- Fungal Infections and Studies
- Inflammatory mediators and NSAID effects
- Tea Polyphenols and Effects
- Phytochemistry Medicinal Plant Applications
- Synthesis and Characterization of Heterocyclic Compounds
- Reproductive tract infections research
- Fern and Epiphyte Biology
- Insect and Pesticide Research
Universidade Estadual Paulista (Unesp)
2017-2024
Isobavachalcone (IBC) is a natural prenylated chalcone with broad spectrum of pharmacological properties. In this work, we newly synthesized and investigated the antibacterial activity IBC against Gram-positive, Gram-negative mycobacterial species. was active Gram-positive bacteria, mainly Methicillin-Susceptible Staphylococcus aureus (MSSA) Methicillin-Resistant (MRSA), minimum inhibitory concentration (MIC) values 1.56 3.12 µg/mL, respectively. On other hand, not able to act species (MIC >...
Dermatophytes, fungi that cause dermatophytosis, can invade keratinized tissues in humans and animals. The biofilm-forming ability of these was described recently, it may be correlated with the long treatment period common recurrences this mycosis. In study, we evaluated anti-dermatophytic anti-biofilm activity 2-hydroxychalcone (2-chalcone) dark photodynamic therapy (PDT)-mediated to determine its mechanism action. Trichophyton rubrum mentagrophytes strains were used study. antifungal...
Abstract Zika virus (ZIKV) is a mosquito-transmitted Flavivirus, originally identified in Uganda 1947 and recently associated with large outbreak South America. Despite extensive efforts there are currently no approved antiviral compounds for treatment of ZIKV infection. Here we describe the activity diarylamines derived from anthranilic acid (FAMs) against ZIKV. A synthetic FAM (E3) demonstrated anti-ZIKV potential by reducing viral replication up to 86%. We analyzed possible mechanisms...
Oropouche virus (OROV) is an emerging vector-borne arbovirus found in South America that causes fever, a febrile infection similar to dengue fever. It has high epidemic potential, causing illness over 500,000 cases diagnosed since the was first discovered 1955. Currently, prevention of human viral depends on vaccination, but availability for many viruses limited, and they are classified as neglected viruses. At present, there no vaccines or antiviral treatments available. An alternative...
Although the past epidemic of Zika virus (ZIKV) resulted in severe neurological consequences for infected infants and adults, there are still no approved drugs to treat ZIKV infection. In this study, we applied computational approaches screen an in-house database 77 natural semi-synthetic compounds against NS5 RNA-dependent RNA-polymerase (NS5 RdRp), essential protein viral RNA elongation during replication process. For purpose, integrated such as binding-site conservation, chemical space...
Hepatitis C virus (HCV) affects about 170 million people worldwide. The current treatment has a high cost and variable response rates according to the genotype. Acridones, group of compounds extracted from natural sources, showed potential antiviral actions against HCV. Thus, this study aimed evaluate effect panel 14 synthetic acridones on HCV life cycle. were screened using an Huh7.5 cell line stably harbouring genotype 2a subgenomic replicon SGR-Feo-JFH-1. Cells incubated in presence or...
Abstract Objective This study aimed to assess the effect of a novel synthetic chalcone, Chalcone T4, on murine model periodontitis and RANKL‐induced osteoclastogenesis in vitro. Background Chalcones are natural compounds with anti‐inflammatory properties, its analogs enhanced biological effects have potential as therapeutic agents. Periodontitis is characterized by chronic inflammation periodontium alveolar bone resorption. Safe effective agents can an important additive treatment this...
Vulvovaginal candidiasis (VVC) remains a prevalent fungal disease, characterized by challenges, such as increased resistance, side effects of current treatments, and the rising prevalence non-
Kombucha is obtained by fermentation of tea and sugar bacteria yeast. This beverage has several beneficial effects, including antimicrobial activity. The objective this study was to evaluate the antifungal activity extracts against dermatomycosis-causing fungi. Different types (black, white, green tea) times (10, 20, 30 days) were evaluated. Kombuchas filtered, liquid-liquid extraction with ethyl acetate. Minimum inhibitory concentrations (MIC) determined clinical isolates dermatophytes...
Chalcones are phenolic compounds with biological properties. This study had the aim to evaluate effects of topical administration a new synthetic chalcone, Chalcone T4, in an animal model periodontitis induced by ligature. Forty rats were distributed following experimental groups: negative control (without and application distilled water), positive (periodontitis chalcone I II 0.6 mg/mL 1.8 mg/mL, respectively). or water was administered into gingival sulcus first molars daily for 10 days,...
Background: Photodynamic therapy (PDT) is a treatment modality that uses light to activate photosensitizing agent, destroying target cells. The growing awareness of the necessity reduce or eliminate use mammals in research has prompted search for safer toxicity testing models aligned with new global guidelines and compliant relevant regulations. Objective: objective this study was assess impact PDT on alternative mammals, including vitro three-dimensional (3D) cultures vivo, invertebrate...
Chalcones are phenolic compounds produced during the biosynthesis of flavonoids that have numerous biological activities, including anti-inflammatory, antioxidant and anticancer. In this in vitro study, we investigate a newly synthesized chalcone (Chalcone T4) context bone turnover, specifically on modulation osteoclast differentiation activity osteoblast differentiation. Murine macrophages (RAW 264.7) pre-osteoblasts (MC3T3-E1) were used as models osteoclasts osteoblasts, respectively....