A5047816364- Oral microbiology and periodontitis research
- Inflammatory mediators and NSAID effects
- Bone Metabolism and Diseases
- Protease and Inhibitor Mechanisms
- Bone and Dental Protein Studies
- Spondyloarthritis Studies and Treatments
- Cytokine Signaling Pathways and Interactions
- Curcumin's Biomedical Applications
- Synthesis and biological activity
- Bone health and treatments
- Peptidase Inhibition and Analysis
- Surgical Sutures and Adhesives
- Pharmacological Effects of Natural Compounds
- Rheumatoid Arthritis Research and Therapies
Universidade Estadual Paulista (Unesp)
2020-2025
Centro Universitário de Araraquara
2020-2024
Universidade de São Paulo
2020
Abstract Objective This study aimed to assess the effect of a novel synthetic chalcone, Chalcone T4, on murine model periodontitis and RANKL‐induced osteoclastogenesis in vitro. Background Chalcones are natural compounds with anti‐inflammatory properties, its analogs enhanced biological effects have potential as therapeutic agents. Periodontitis is characterized by chronic inflammation periodontium alveolar bone resorption. Safe effective agents can an important additive treatment this...
Chalcones are phenolic compounds with biological properties. This study had the aim to evaluate effects of topical administration a new synthetic chalcone, Chalcone T4, in an animal model periodontitis induced by ligature. Forty rats were distributed following experimental groups: negative control (without and application distilled water), positive (periodontitis chalcone I II 0.6 mg/mL 1.8 mg/mL, respectively). or water was administered into gingival sulcus first molars daily for 10 days,...
Background: Chalcones, a group of phenolic compounds derivate from plants, has displayed wide spectrum biological activities, as anti-inflammatory, antioxidant, antimicrobial and anti-resorptive. It can act on number targets the inflammatory process, including transcription factors, adhesion molecules, intracellular signaling mediators that are essential in process osteoclast activation differentiation. Aim/Hypothesis: Considering its biologic objective this study was to assess, for first...