A5016270455- Head and Neck Cancer Studies
- Cancer, Stress, Anesthesia, and Immune Response
- Brain Metastases and Treatment
- Cancer Diagnosis and Treatment
- Brain Tumor Detection and Classification
- Hepatocellular Carcinoma Treatment and Prognosis
- Glioma Diagnosis and Treatment
- Oral Health Pathology and Treatment
- Head and Neck Surgical Oncology
- Circular RNAs in diseases
- Radiomics and Machine Learning in Medical Imaging
- Cancer-related molecular mechanisms research
- Peripheral Nerve Disorders
- Ultrasound and Hyperthermia Applications
- Infrared Thermography in Medicine
- Oral microbiology and periodontitis research
- Nonmelanoma Skin Cancer Studies
- Salivary Gland Tumors Diagnosis and Treatment
- Laser Applications in Dentistry and Medicine
- dental development and anomalies
- Streptococcal Infections and Treatments
- Inflammatory mediators and NSAID effects
- Bone and Dental Protein Studies
- Bone Metabolism and Diseases
- Bone health and treatments
University of Michigan
2021-2023
Centro Universitário de Araraquara
2020-2022
Universidade Estadual Paulista (Unesp)
2020-2022
Perineural invasion (PNI), a common occurrence in oral squamous cell carcinomas, is associated with poor survival. Consequently, these tumors are treated aggressively. However, diagnostic criteria of PNI vary and its role as an independent predictor prognosis has not been established. To address knowledge gaps, we investigated spatial transcriptomic profiles PNI-positive PNI-negative nerves.Tissue sections from 142 patients were stained S100 cytokeratin antibodies. Nerves identified two...
Abstract Objective This study aimed to assess the effect of a novel synthetic chalcone, Chalcone T4, on murine model periodontitis and RANKL‐induced osteoclastogenesis in vitro. Background Chalcones are natural compounds with anti‐inflammatory properties, its analogs enhanced biological effects have potential as therapeutic agents. Periodontitis is characterized by chronic inflammation periodontium alveolar bone resorption. Safe effective agents can an important additive treatment this...
<div>AbstractPurpose:<p>Perineural invasion (PNI), a common occurrence in oral squamous cell carcinomas, is associated with poor survival. Consequently, these tumors are treated aggressively. However, diagnostic criteria of PNI vary and its role as an independent predictor prognosis has not been established. To address knowledge gaps, we investigated spatial transcriptomic profiles PNI-positive PNI-negative nerves.</p>Experimental Design:<p>Tissue sections from 142...
Supplementary Data from Spatial and Transcriptomic Analysis of Perineural Invasion in Oral Cancer
<div>AbstractPurpose:<p>Perineural invasion (PNI), a common occurrence in oral squamous cell carcinomas, is associated with poor survival. Consequently, these tumors are treated aggressively. However, diagnostic criteria of PNI vary and its role as an independent predictor prognosis has not been established. To address knowledge gaps, we investigated spatial transcriptomic profiles PNI-positive PNI-negative nerves.</p>Experimental Design:<p>Tissue sections from 142...
Supplementary Data from Spatial and Transcriptomic Analysis of Perineural Invasion in Oral Cancer
<p>This figure shows that Tongue SCC patients with IND equal or larger than T-AND have poor DSS</p>
<p>This figure show the association of NND with differentiation, Stage, patter invasion and PNI</p>
<p>This figure shows the correlation between depth of invasion and nerve density measurements, nerve-tumor distance in tongue SCC</p>
<div>AbstractPurpose:<p>Perineural invasion (PNI) in oral cavity squamous cell carcinoma (OSCC) is associated with poor survival. Because of the risk recurrence, patients PNI receive additional therapies after surgical resection. Mechanistic studies have shown that nerves tumor microenvironment promote aggressive growth. Therefore, this study, we evaluated whether nerve density (ND) influences growth and patient Moreover, assessed reliability artificial intelligence (AI)...
<div>AbstractPurpose:<p>Perineural invasion (PNI) in oral cavity squamous cell carcinoma (OSCC) is associated with poor survival. Because of the risk recurrence, patients PNI receive additional therapies after surgical resection. Mechanistic studies have shown that nerves tumor microenvironment promote aggressive growth. Therefore, this study, we evaluated whether nerve density (ND) influences growth and patient Moreover, assessed reliability artificial intelligence (AI)...
<p>This figure shows the correlation between depth of invasion and nerve density measurements, nerve-tumor distance in tongue SCC</p>
<p>This figure show the association of NND with differentiation, Stage, patter invasion and PNI</p>