A5067301204- Mosquito-borne diseases and control
- Viral Infections and Vectors
- Malaria Research and Control
- Insect and Pesticide Research
- Viral Infections and Outbreaks Research
- Vector-Borne Animal Diseases
- Hops Chemistry and Applications
- Virus-based gene therapy research
- Virology and Viral Diseases
- vaccines and immunoinformatics approaches
- COVID-19 epidemiological studies
- SARS-CoV-2 and COVID-19 Research
- Vector-borne infectious diseases
- Bioactive natural compounds
- Liver Disease Diagnosis and Treatment
- Iron oxide chemistry and applications
- Toxin Mechanisms and Immunotoxins
- Microbial infections and disease research
- Nanoparticles: synthesis and applications
- Liver Disease and Transplantation
- Computational Drug Discovery Methods
- Free Radicals and Antioxidants
- HIV, Drug Use, Sexual Risk
- COVID-19 Clinical Research Studies
- Magnetic Properties and Synthesis of Ferrites
Faculdade de Medicina de São José do Rio Preto
2021-2024
Brazilian Biosciences National Laboratory
2022-2024
Brazilian Center for Research in Energy and Materials
2022-2024
The University of Texas Medical Branch at Galveston
2024
Laboratório Nacional de Ciência e Tecnologia do Bioetanol
2022-2024
Universidade Federal de Jataí
2019-2022
Universidade Federal de Goiás
2017-2019
Ilhéus virus (ILHV) is a neglected mosquito-borne flavivirus. ILHV infection may lead to fever, an emerging febrile disease like dengue fever with the potential evolve into severe neurological characterized by meningoencephalitis; no specific treatments are available for this disease. This study assessed antiviral properties of caffeic acid, abundant component plant-based food products that also compatible socioeconomic limitations associated infectious The in vitro activity acid on...
Oropouche virus (OROV) is a member of the
Abstract Melatonin receptors MT 1 and 2 are G protein-coupled that mediate the effects of melatonin, a hormone involved in circadian rhythms other physiological functions. Understanding molecular interactions between these their ligands is crucial for developing novel therapeutic agents. In this study, we used docking, dynamics simulations, quantum mechanics calculation to investigate binding modes affinities three ligands: melatonin (MLT), ramelteon (RMT), 2-phenylmelatonin (2-PMT) with...
Cacipacoré virus (CPCV) was discovered in 1977 deep the Amazon rainforest, from blood of a black-faced ant thrush (Formicarius analis). As member family Flaviviridae, genus orthoflavivirus, CPCV's intricate ecological association with vectors and hosts raises profound questions. CPCV’s transmission cycle may involve birds, rodents, equids, bovines, marsupials, non-human primates bats as potential vertebrate hosts, whereas Culex Aedes spp mosquitoes, have been implicated...
Nanoparticles (NPs) have a wide range of applications in various areas. For health application, cytotoxicity tests are used to ensure its efficiency and safety. In this paper, ZnFe2O4, CoFe2O4, Zn0.5Co0.5Fe2O4 NPs were synthesized, characterized their antibacterial properties evaluated. The Sol-Gel method was synthesize the NPs. Their electronic crystallographic structures by Fourier Transform Infrared Spectroscopy Analysis (FTIR), X-ray fluorescence (XRF), X-Ray Diffraction (XRD),...
The arbovirus Chikungunya (CHIKV) is transmitted by Aedes mosquitoes in urban environments, and humans, it triggers debilitating symptoms involving long-term complications, including arthritis Guillain-Barré syndrome. development of antiviral therapies relevant, as no efficacious vaccine or drug has yet been approved for clinical application. As a detailed map molecules underlying the viral infection can be obtained from metabolome, we validated metabolic signatures Vero E6 cells prior to...
Inhibition of HIV-1 protease is a cornerstone antiretroviral therapy.
Oropouche virus (OROV) is an emerging vector-borne arbovirus found in South America that causes fever, a febrile infection similar to dengue fever. It has high epidemic potential, causing illness over 500,000 cases diagnosed since the was first discovered 1955. Currently, prevention of human viral depends on vaccination, but availability for many viruses limited, and they are classified as neglected viruses. At present, there no vaccines or antiviral treatments available. An alternative...
Zika virus (ZIKV) has re-emerged in recent decades, leading to outbreaks of fever Africa, Asia, and Central South America. Despite its drastic re-emergence clinical impact, no vaccines or antiviral compounds are available prevent control ZIKV infection. This study evaluated the potential activity quercetin hydrate against infection demonstrated that this substance inhibits particle production A549 Vero cells under different treatment conditions. In vitro was long-lasting (still observed 72 h...
Recent seroprevalence studies in animals detected Rocio virus regions of Brazil, indicating risk for re-emergence this pathogen. We identified RNA samples from 2 human patients whom dengue fever was clinically suspected but ruled out by laboratory findings. Testing infrequent flavivirus infections should expedite diagnoses.
Diseases caused by viruses of the genus Flavivirus are among main diseases that affect world and they a serious public health problem. Three them stand out: Dengue, Yellow fever Zika viruses. The non-structural protein 1 (NS1), encoded this viral genus, in its dimeric form, plays important roles pathogenesis RNA replication these Therefore, identification chemicals with potential to inhibit formation NS1 dimer DENV, YFV ZIKV would enable act as multi-target drug. For this, we selected...
Chikungunya virus (CHIKV) is an arthropod-borne that belongs to the genus Alphavirus (family Togaviridae). CHIKV causes chikungunya fever, which mostly characterized by arthralgia and, sometimes, a maculopapular rash. The bioactive constituents of hops (Humulus lupulus, Cannabaceae), mainly acylphloroglucinols, known as well α- and β-acids, exerted distinct activity against CHIKV, without showing cytotoxicity. For fast efficient isolation identification such constituents, silica-free...
Cacipacoré virus (CPCV) was discovered in 1977 deep the Amazon rainforest from blood of a black-faced ant thrush (Formicarius analis). As member family Flaviviridae and genus orthoflavivirus, CPCV’s intricate ecological association with vectors hosts raises profound questions. transmission cycle may involve birds, rodents, equids, bovines, marsupials, non-human primates, bats as potential vertebrate hosts, whereas Culex Aedes spp. mosquitoes have been implicated transmission. The virus’...
Brazil has earned the moniker “arbovirus hotspot”, providing an ideal breeding ground for a multitude of arboviruses thriving in various zoonotic and urban cycles. As planet warms vectors expand their habitat range, nuanced understanding lesser-known factors that could drive emergence becomes imperative. Among these viruses is Iguape virus (IGUV), member Orthoflavivirus aroaense species, which was first isolated 1979 from sentinel mouse municipality Iguape, within Vale do Ribeira region São...
Abstract The Brazilian regions are still highly endemic areas for Canine morbillivirus [canine distemper virus (CDV)]. However, little is known regarding the genetic variability of strain circulating in several regions. Here, we report first full-length genome and molecular characterization CDV isolated from domestic dogs Center-West region. Sequence alignment phylogenetic analyses based on deduced amino acid nucleotide sequences showed that characterized as South America-I/Europe genotype....
The Oropouche virus (OROV) is a member of the family Peribunyaviridae (order Bunyavirales) and cause dengue-like febrile illness transmitted mainly by biting midges mosquitoes. In this study, we aimed to explore acylphloroglucinols xanthohumol from hops (Humulus lupulus L.) as promising alternative for antiviral therapies. evaluation inhibitory potential compounds on viral cycle OROV was performed through two complementary approaches. first approach applies cell-based assay post-inoculation...
The Mayaro virus is endemic to South America, and the possible involvement of Aedes spp. mosquitoes in its transmission a risk factor for outbreaks greater proportions. causes potentially disabling illness known as fever, which similar that caused by chikungunya virus. cocirculation both viruses, with their clinical structural similarities, absence prophylactic therapeutic measures highlight need studies seek understand Using approaches silico, we identified an antigenic specific epitope...
Flaviviruses are among the most critical pathogens in tropical regions; they cause various severe diseases developing countries but not restricted to these countries. The development of antiviral therapeutics is crucial for managing flavivirus outbreaks. Ten proteins encoded RNA. N2B–NS3pro protein complex plays a fundamental role replication and promising drug target; however, no protease inhibitors have progressed preclinical stage. This study analyzed structural models plasticity...