A5028803967- Mosquito-borne diseases and control
- Malaria Research and Control
- Viral Infections and Outbreaks Research
- Viral Infections and Vectors
- Systemic Lupus Erythematosus Research
- HIV Research and Treatment
- vaccines and immunoinformatics approaches
- Immune cells in cancer
- Vector-borne infectious diseases
- Growth Hormone and Insulin-like Growth Factors
- Lymphoma Diagnosis and Treatment
- Monoclonal and Polyclonal Antibodies Research
- Thyroid Disorders and Treatments
- Cell Adhesion Molecules Research
- Diabetes and associated disorders
- Brucella: diagnosis, epidemiology, treatment
- Immune Cell Function and Interaction
- Stress Responses and Cortisol
- Atherosclerosis and Cardiovascular Diseases
- Hepatitis B Virus Studies
- Vibrio bacteria research studies
- Complement system in diseases
- Immune Response and Inflammation
- Virology and Viral Diseases
- T-cell and B-cell Immunology
Jenner Institute
2015-2019
University of Oxford
2015-2019
Paul Ehrlich Institut
2019
Mexican Social Security Institute
2011-2013
Centro Medico Nacional Siglo XXI
2010-2013
Chikungunya virus (CHIKV) has caused extensive outbreaks in several countries within the Americas, Asia, Oceanic/Pacific Islands, and Europe. In humans, CHIKV infections cause a debilitating disease with acute febrile illness long-term polyarthralgia. Acute chronic symptoms impose major economic burden to health systems contribute poverty affected countries. An efficacious vaccine would be an important step towards decreasing by infection. Despite no licensed is yet available for CHIKV,...
ABSTRACT Plasmodium vivax is now the dominant species causing malaria in Thailand, yet little known about naturally acquired immune responses to this parasite low-transmission region. The preerythrocytic stage of P. life cycle considered an excellent target for a vaccine, and study, we assessed stability seropositivity magnitude IgG three different proteins two groups adults from region western Thailand where endemic. These individuals were enrolled yearlong cohort which comprised one group...
Abstract Development of a protective and broadly-acting vaccine against the most widely distributed human malaria parasite, Plasmodium vivax , will be major step towards elimination. However, P. has remained elusive by scarcity pre-clinical models to test efficacy support further clinical trials. In this study, we report development highly CSP-based vaccine, virus-like particle (VLP) known as Rv21, able provide 100% sterile protection stringent sporozoite challenge in rodent malaria, where...
Abstract Background Prolactin is secreted from the pituitary gland and other organs, as well by cells such lymphocytes. has an immunostimulatory effect associated with autoimmune diseases that are characterised abnormal B cell activation, systemic lupus erythematosus (SLE). Our aim was to determine if different splenic subsets express prolactin receptor presence of influences these correlates development lupus. Results Using real-time PCR flow cytometry, we found immature (transitional)...
Among its many functions, prolactin (PRL) participates in immune responses and promotes the activation, differentiation proliferation of T cells. However, mechanisms by which PRL regulates regulatory (T(reg)) cells are still unknown. Our goal was to determine whether plays a role T(reg) function. We measured expression receptor effector (T(eff)) from 15 healthy individuals. also evaluated functional activity examining cytokine secretion activated with anti-CD3/CD28 presence or absence PRL....
Microcrystalline Tyrosine (MCT®) is a widely used proprietary depot excipient in specific immunotherapy for allergy. In the current study we assessed potential of MCT to serve as an adjuvant development vaccine against malaria. To this end, formulated circumsporozoite protein (CSP) P. vivax and compared induced immune responses CSP PBS or Alum. Both Alum strongly increased immunogenicity both C57BL/6 BALB/c mice. Challenge studies mice using chimeric bergei expressing demonstrated clinically...
Recent seroprevalence studies in animals detected Rocio virus regions of Brazil, indicating risk for re-emergence this pathogen. We identified RNA samples from 2 human patients whom dengue fever was clinically suspected but ruled out by laboratory findings. Testing infrequent flavivirus infections should expedite diagnoses.
Prolactin (PRL) is a 23-kDa protein hormone that synthesized mainly by the anterior pituitary gland. However, PRL can also be and secreted extrapituitary tissues, particularly immune cells. A biallelic polymorphism (−1149 G/T) in prolactin promoter has been shown to functionally important, as modulation of expression associated with SLE some populations. We have performed an association study using Mexican patients SLE. used qPCR determine SNP allele genotype frequencies. did not find...