A5030819292- Systemic Lupus Erythematosus Research
- T-cell and B-cell Immunology
- Immune Cell Function and Interaction
- Atherosclerosis and Cardiovascular Diseases
- Immune Response and Inflammation
- Adipokines, Inflammation, and Metabolic Diseases
- Immune cells in cancer
- Neutrophil, Myeloperoxidase and Oxidative Mechanisms
- Adrenal Hormones and Disorders
- Mesenchymal stem cell research
- Diabetes and associated disorders
- Monoclonal and Polyclonal Antibodies Research
- Growth Hormone and Insulin-like Growth Factors
- Cytokine Signaling Pathways and Interactions
- Cell Adhesion Molecules Research
- Toxin Mechanisms and Immunotoxins
- Coronary Interventions and Diagnostics
- Bone Metabolism and Diseases
- Electrospun Nanofibers in Biomedical Applications
- Helicobacter pylori-related gastroenterology studies
- Extracellular vesicles in disease
- Cervical Cancer and HPV Research
- Pancreatic function and diabetes
- Hematopoietic Stem Cell Transplantation
- MicroRNA in disease regulation
Mexican Social Security Institute
2012-2025
Centro Medico Nacional Siglo XXI
2010-2025
The development of B cells into antibody-secreting plasma is central to the adaptive immune system as they induce protective and specific antibody responses against invading pathogens. Various studies have shown that, during this process, hormones can play important roles in lymphopoiesis, activation, proliferation, differentiation cells, depending on signal given by receptor each hormone, a positive or negative effect. In autoimmune diseases, hormonal deregulation has been reported be...
Bone marrow-mesenchymal stromal cells (BM-MSCs) have immunosuppressive properties and been used in cell therapies as immune regulators for the treatment of graft-versus-host disease. We previously characterized several biological MSCs from placenta (PL) umbilical cord blood (UCB), compared them to those BM-the gold standard. In present study, we BM, UCB, PL terms their against lymphoid populations enriched CD3(+) T cells. Our results confirm potential BM-MSCs, demonstrate that UCB and, a...
Type 1 diabetes (T1D) is a complex disease driven by the immune system attacking insulin-producing beta cells in pancreas. Understanding role of different T cell subpopulations development and progression T1D crucial. By employing flow cytometry to compare characteristics cells, we can pinpoint potential indicators treatment response or therapeutic inefficacy. Our study reveals elevated prolactin (PRL) levels patients, along with decreased production key cytokines. Additionally, PD1 appears...
Prolactin (PRL) plays an important role in modulating the immune response. In B cells, PRL enhances antibody production, including antibodies with self-specificity. this study, our aims were to determine level of receptor expression during bone-marrow B-cell development and assess whether presence high serum concentrations influences absolute numbers developing populations disease outcome lupus-prone murine models. We observed that PRL-receptor is expressed early B-cell; mice, which had...
Prolactin has different functions, including cytokine secretion and inhibition of the suppressor effect regulatory T (Treg) cells in healthy individuals. Systemic lupus erythematosus (SLE) is an autoimmune disease characterized by defects functions B, T, Treg cells. plays important role physiopathology SLE. Our objective was to establish participation prolactin regulation immune response mediated from patients with CD4+CD25hiCD127−/low were purified using magnetic beads relative expression...
Abstract Background Prolactin is secreted from the pituitary gland and other organs, as well by cells such lymphocytes. has an immunostimulatory effect associated with autoimmune diseases that are characterised abnormal B cell activation, systemic lupus erythematosus (SLE). Our aim was to determine if different splenic subsets express prolactin receptor presence of influences these correlates development lupus. Results Using real-time PCR flow cytometry, we found immature (transitional)...
Among its many functions, prolactin (PRL) participates in immune responses and promotes the activation, differentiation proliferation of T cells. However, mechanisms by which PRL regulates regulatory (T(reg)) cells are still unknown. Our goal was to determine whether plays a role T(reg) function. We measured expression receptor effector (T(eff)) from 15 healthy individuals. also evaluated functional activity examining cytokine secretion activated with anti-CD3/CD28 presence or absence PRL....
H. pylori infection is the most important environmental risk to develop gastric cancer, mainly through its virulence factor CagA. In vitro models of CagA function have demonstrated a phosphoprotein activity targeting multiple cellular signaling pathways, while cagA transgenic mice carcinomas gastrointestinal tract, supporting oncogenic functions. However, it still not completely clear how alters processes associated with carcinogenic events. this study, we evaluated capacity positive and...
The differentiation capacity, hematopoietic support, and immunomodulatory properties of human bone marrow mesenchymal stromal cells (BM-MSCs) make them attractive therapeutic agents for a wide range diseases. Clinical scale cultures (CSCs) have been used to expand BM-MSCs their use in cell therapy protocols; however, little is known about the functionality expanded cells. main goal present study was evaluate functional characteristics from CSCs determine quality cellular protocols. To...
Systemic lupus erythematosus (SLE) mainly affects females at reproductive age, which has been associated with hormones, such as prolactin (PRL). Different studies suggest that PRL exacerbates the clinical manifestations of SLE both in patients and mouse models (e.g., MRL/lpr strain), increasing production autoantibodies, can be deposited immune complexes trigger inflammation damage to different tissues. The objective this work was explore potential mechanisms by increases concentration...
Prolactin (PRL) is a 23-kDa protein hormone that synthesized mainly by the anterior pituitary gland. However, PRL can also be and secreted extrapituitary tissues, particularly immune cells. A biallelic polymorphism (−1149 G/T) in prolactin promoter has been shown to functionally important, as modulation of expression associated with SLE some populations. We have performed an association study using Mexican patients SLE. used qPCR determine SNP allele genotype frequencies. did not find...
Systemic lupus erythematosus is characterized by high levels of IgG class autoantibodies that contribute to the pathophysiology disease. The formation these occurs in germinal centers, where there cooperation between follicular T helper cells (TFH) and autoreactive B cells. Prolactin has been reported exacerbate clinical manifestations increasing autoantibody concentrations. objective this study was characterize participation prolactin differentiation activation TFH cells, performing vivo...
Abstract Background Most infections with human papillomavirus (HPV) are resolved without clinical intervention, but a minority evolves into chronic lesions of distinct grades, including cervical-uterine cancer. It is known that in most cases the immune system mediates elimination HPV infection. However, mechanism evasion leading to persistence and development early cervical not fully understood. The aim present work was evaluate potential peripheral blood leukocytes (PBL) from low-grade...
Pro-inflammatory molecules and low-density lipoproteins play essential roles in the atherosclerosis. The aim of our study was to establish an association among cytokines secreted by peripheral blood mononuclear cells serum concentration patients with unstable angina coronary outward remodeling before after percutaneous intervention. clinical responses were evaluated 6 months procedure. Twenty-two prior intervention procedure intravascular ultrasound. Eleven had recurrent angina, while 9...
Cnidoscolus tehuacanensis is an endemic medicinal species used to treat some inflammatory diseases, and biosynthesizes triterpenes sterols, being Lupeol Acetate (LuAc) the main compound. It was submitted biological assay determine anti-inflammatory leishmanicidal potential. Anti-inflammatory effect determined on acute (12-O-tetradecanoylphorbol-13-acetate -TPA- Carragenan models) chronic models (induce with Complet Freud´s Adjuvant -CFA-) using Indomethacin Phenylbutazone (PBZ) as reference...