A5037220072- vaccines and immunoinformatics approaches
- SARS-CoV-2 and COVID-19 Research
- Mosquito-borne diseases and control
- Monoclonal and Polyclonal Antibodies Research
- Computational Drug Discovery Methods
- Phytochemical compounds biological activities
- T-cell and Retrovirus Studies
- Circadian rhythm and melatonin
- Tuberculosis Research and Epidemiology
- Antimicrobial Peptides and Activities
- Protein purification and stability
- Virology and Viral Diseases
- Bacteriophages and microbial interactions
- Helicobacter pylori-related gastroenterology studies
- Phytoestrogen effects and research
- Probiotics and Fermented Foods
- Influenza Virus Research Studies
- Pneumonia and Respiratory Infections
- Stress Responses and Cortisol
- Free Radicals and Antioxidants
- Biochemical and Structural Characterization
- Biochemical and Molecular Research
- Cancer therapeutics and mechanisms
Universidade Federal do Rio Grande do Norte
2019-2024
Universidade Federal do Rio Grande
2023
Abstract Gastric cancer is considered a class 1 carcinogen that closely linked to infection with Helicobacter pylori ( H. ), which affects over million people each year. However, the major challenge fight against and its associated gastric due drug resistance. This research gap had led our team investigate potential candidate targeting ‐carcinogenic TNF‐alpha‐inducing protein. In this study, total of 45 daidzein derivatives were investigated best 10 molecules comprehensively using in silico...
Abstract The rise of pyrazinamide (PZA)‐resistant strains Mycobacterium tuberculosis (MTB) poses a major challenge to conventional (TB) treatments. PZA, cornerstone TB therapy, must be activated by the mycobacterial enzyme pyrazinamidase (PZase) convert its active form, pyrazinoic acid, which targets ribosomal protein S1. Resistance, often associated with mutations in RpsA protein, complicates treatment and highlights critical gap understanding structural dynamics mechanisms resistance,...
Abstract Yellow fever outbreaks are prevalent, particularly in endemic regions. Given the lack of an established treatment for this disease, significant attention has been directed toward managing arbovirus. In response, we developed a multiepitope vaccine designed to elicit immune utilizing advanced immunoinformatic and molecular modeling techniques. To achieve this, predicted B- T-cell epitopes using sequences from all structural (E, prM, C) nonstructural proteins 196 YFV strains. Through...
Abstract Melatonin receptors MT 1 and 2 are G protein-coupled that mediate the effects of melatonin, a hormone involved in circadian rhythms other physiological functions. Understanding molecular interactions between these their ligands is crucial for developing novel therapeutic agents. In this study, we used docking, dynamics simulations, quantum mechanics calculation to investigate binding modes affinities three ligands: melatonin (MLT), ramelteon (RMT), 2-phenylmelatonin (2-PMT) with...
Streptococcus pneumoniae is a major pathogen that poses significant hazard to global health, causing variety of infections including pneumonia, meningitis, and sepsis. The emergence antibiotic-resistant strains has increased the difficulty conventional antibiotic treatment, highlighting need for alternative therapies such as multi-epitope vaccines. In this study, immunoinformatics algorithms were used identify potential vaccine candidates based on extracellular immunogenic protein...
Abstract SARS-CoV-2 is the virus responsible for COVID-19 pandemic, which has spread rapidly around world and had a significant impact on public health economy worldwide. This study investigated correlation between spike protein mutations, clinical outcomes patient demographics in Sylhet region of Bangladesh. We looked at full genome sequences 37 samples that were collected January June 2020. Specifically, we five major mutations: D614G, A570D, D1118H, A222V, P681R. The D614G mutation was...