A5093472630- vaccines and immunoinformatics approaches
- Monoclonal and Polyclonal Antibodies Research
- Pneumonia and Respiratory Infections
- Respiratory viral infections research
- Bacteriophages and microbial interactions
- Biochemical and Structural Characterization
- Transgenic Plants and Applications
- Viral gastroenteritis research and epidemiology
Jagannath University
2023-2025
Streptococcus pneumoniae (SPN) is a significant pathogen causing pneumonia and meningitis, particularly in vulnerable populations like children the elderly. Available vaccines have limitations since they only cover particular serotypes high production costs. The emergence of antibiotic-resistant SPN strains further underscores need for new, cost-effective, broad-spectrum vaccine. Two potential vaccine candidates, CbpA PspA, were identified, their B-cell, CTL, HTL epitopes predicted connected...
Helicobacter pylori is a gram-negative bacterium that persistently infects the human stomach, leading to peptic ulcers, gastritis, and an increased risk of gastric cancer. The extremophilic characteristics this make it resistant current drug treatments, there are no licensed vaccines available against H. pylori. Computational approaches offer viable alternative for designing antigenic, stable, safe control infections caused by pathogen. In study, we employed immunoinformatic strategy design...
Streptococcus pneumoniae is a major pathogen that poses significant hazard to global health, causing variety of infections including pneumonia, meningitis, and sepsis. The emergence antibiotic-resistant strains has increased the difficulty conventional antibiotic treatment, highlighting need for alternative therapies such as multi-epitope vaccines. In this study, immunoinformatics algorithms were used identify potential vaccine candidates based on extracellular immunogenic protein...