Lígia de Souza Fernandes

ORCID: 0000-0002-7072-0922
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About
Contact & Profiles
Research Areas
  • Advancements in Transdermal Drug Delivery
  • Curcumin's Biomedical Applications
  • Diverse Scientific Research Studies
  • Antifungal resistance and susceptibility
  • Advanced Drug Delivery Systems
  • Protein Hydrolysis and Bioactive Peptides
  • Nanoparticle-Based Drug Delivery
  • Essential Oils and Antimicrobial Activity
  • Nail Diseases and Treatments
  • Chemical Synthesis and Analysis
  • Viral Infectious Diseases and Gene Expression in Insects
  • Phytochemical compounds biological activities
  • Marine Sponges and Natural Products
  • Fish Biology and Ecology Studies
  • RNA Interference and Gene Delivery
  • Entomopathogenic Microorganisms in Pest Control
  • Herbal Medicine Research Studies
  • Insect Utilization and Effects
  • Animal testing and alternatives

Universidade Estadual Paulista (Unesp)
2018-2024

Aims: The development of rapamycin (RAP) and resveratrol (RSV) coloaded liposomes (RAP-RSV-LIP) for breast cancer therapy. Materials & methods: Liposomes were prepared using a high-pressure homogenization technique evaluated according to their physicochemical characteristics, cellular uptake cytotoxicity against tumoral normal cells. Results conclusion: RAP-RSV-LIP showed negative surface charge, size around 100 nm, low polydispersity high encapsulation efficiency RAP RSV (58.87 63.22%,...

10.2217/nnm-2022-0227 article EN Nanomedicine 2023-04-01

Summary Owing to the growing resistance among isolates of Candida species usual antifungal agents and well‐known therapeutic potential curcumin, purpose this study was develop validate a vaginal formulation containing substance evaluating its effectiveness in treatment experimental vulvovaginal candidiasis. Curcumin incorporated cream three concentrations (0.01%, 0.1% 1.0%). The different controls were intravaginally administered an immunosuppressed rat model evaluate efficacy Samples also...

10.1111/myc.12762 article EN Mycoses 2018-03-08

Vulvovaginal candidiasis is a public health problem with high incidence among female patients. Currently, there an increase in the identification of Candida spp. resistant to current therapy, making it necessary search for new therapeutic alternatives. The synergistic potential curcumin fluconazole described literature. However, due its lipophilicity, use drug-delivery systems adequately explore potential, which nanostructured lipid carrier. date, no validated method high-performance liquid...

10.1002/jssc.202100514 article EN Journal of Separation Science 2021-10-01
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