A5045336981- Helminth infection and control
- Mosquito-borne diseases and control
- Nematode management and characterization studies
- Plant and fungal interactions
- Respiratory viral infections research
- Rabbits: Nutrition, Reproduction, Health
- Insect Pest Control Strategies
- Viral gastroenteritis research and epidemiology
- Growth and nutrition in plants
- Parasites and Host Interactions
- Plant Pathogens and Fungal Diseases
- Fungal Infections and Studies
- Pharmacological Effects of Natural Compounds
- Fern and Epiphyte Biology
- Virology and Viral Diseases
- Agricultural and Food Sciences
- Bee Products Chemical Analysis
- Animal Virus Infections Studies
- Computational Drug Discovery Methods
- Insect and Pesticide Research
- Hepatitis C virus research
- Parasite Biology and Host Interactions
- Drug-Induced Hepatotoxicity and Protection
- Botanical Research and Chemistry
- Plant Toxicity and Pharmacological Properties
Universidade Estadual Paulista (Unesp)
2014-2022
Abstract Hepatitis C virus (HCV) is one of the leading causes liver diseases and transplantation worldwide. The current available therapy for HCV infection based on interferon-α, ribavirin new direct-acting antivirals (DAAs), such as NS3 protease NS5B polymerase inhibitors. However, high costs drug design, severe side effects resistance presented by existing treatments demonstrate need developing more efficient anti-HCV agents. This study aimed to evaluate antiviral sorbifolin ( 1 )...
Human respiratory syncytial virus (hRSV) is one of the main etiological agents diseases lower tract and often responsible for hospitalization children elderly. To date, treatments are only palliative there no vaccine available. Natural products show exceptional structural diversity they have played a vital role in drug research. Several investigations focused on applied modification natural to improved metabolic stability, solubility biological actions them. Quercetin flavonoid that presents...
Abstract Strategies to reduce dependence on synthetic drugs for the treatment of gastrointestinal nematodes (GIN) infections in ruminants include search novel anthelmintic scaffolds plants, yet salt-tolerant plants remain overlooked. This study aims evaluate vitro properties selected against GIN, and identify potential bioactive secondary metabolites involved. For that purpose, 80% acetone/water extracts were prepared from dried biomass aerial organs nine plant species tested Haemonchus...
Although the past epidemic of Zika virus (ZIKV) resulted in severe neurological consequences for infected infants and adults, there are still no approved drugs to treat ZIKV infection. In this study, we applied computational approaches screen an in-house database 77 natural semi-synthetic compounds against NS5 RNA-dependent RNA-polymerase (NS5 RdRp), essential protein viral RNA elongation during replication process. For purpose, integrated such as binding-site conservation, chemical space...
To evaluate anti-Candida and anti-Cryptococcus activities of 15 non-alkaloidal compounds from Pterogyne nitens Tulasne (Leguminosae), a South American medicinal plant. Compounds were submitted to antifungal assays, using microdilution method described by Clinical Laboratory Standards Institute document, with minor modifications. Five species Candida two Cryptococcus, including clinical isolates screened. Antifungal activity was expressed minimum inhibitory concentration (MIC). Amphotericin B...
The human Respiratory Syncytial Virus (hRSV) is the main responsible for occurrences of respiratory diseases as pneumonia and bronchiolitis in children elderly. M2-1 protein from hRSV an important antitermination factor transcription process that prevents premature dissociation polymerase complex, making it a potential target developing inhibitors viral replication. present study reports interaction tetramer with pera (Q1) tetracetylated (Q2) quercetin derivatives, which were synthesized...
The use of plants and their metabolites stands as a promising option to tackle parasitic infections by gastrointestinal nematodes (GIN) in integrated control strategies. Still, the influence environmental phenological factors, interactions, wild on metabolomics biological properties target plant species, is often disregarded. In this work, we hypothesized that variations anthelmintic (AH) chemical composition extracts from salt tolerant species Cladium mariscus L. Pohl (sawgrass) may be...
Objetivou-se e scolher os melhores tratamentos pre-germinativos para as sementes tamanhos de recipiente o desenvolvimento inicial plantas Erythrina mulungu ( Mart. ex. Benth). Dentre aplicados, a escarificacao com acido sulfurico por 10 minutos corte estilete na regiao oposta ao hilo resultaram, respectivamente, nos maiores resultados porcentagem germinacao (82,8% 82,1%) indices velocidade (1,15 1,71). Nao foram observados efeitos do tamanho sobre area foliar producao massa seca das plantas....
Abstract Strategies to reduce dependence on synthetic drugs for the treatment of gastrointestinal nematodes (GIN) infections in ruminants include search novel anthelmintic scaffolds plants, yet salt tolerant plants remain overlooked. The aims this study are evaluate vitro properties selected salt-tolerant against GIN, and identify potential bioactive secondary metabolites involved. For that purpose, 80% acetone/water extracts were prepared from dried biomass aerial organs nine plant species...
Using plants and their metabolites is a valuable strategy to tackle parasitic infections by gastrointestinal nematodes (GIN) in integrated control strategies aiming at reducing dependence on synthetic drugs. Several salt tolerant (halophytes) have ethnoveterinary uses as antiparasitic, are rich bioactive molecules (e.g., tannins), therefore potential sources of anthelminthic phytotherapeutic products. This work explored the tannins content vitro athlelminthic properties towards eggs larvae...