ABSTRACT Background The relational equation for predicting arterial oxygen saturation (SaO 2 ) with a partial pressure of (PaO has been described and used in clinical settings. However, the limitations as it was derived empirically. This study aimed to assess relationship between PaO SaO using turnover model. Material Methods In controlled desaturation accuracy pulse oximeter, volunteers ( n = 12) breathed hypoxic gas mixtures via mouthpiece. Various target values were achieved within range...

Target-controlled infusion (TCI) could provide a patient-tailored approach for vancomycin dosing. This study aimed to externally evaluate the predictive performance of previously constructed pharmacokinetic model (Choi model) specifically optimized TCI administration differing from existing model, and assess feasibility administering via in clinical practice. Additionally, outcomes were exploratively compared between intermittent (standard) methods administration. Clinically ill patients...

In a previous study, the modified Marsh and Schnider models respectively showed negatively- positively-biased predictions in underweight patients. To overcome this drawback, we developed new pharmacokinetic propofol model-the Choi model-for use present evaluated predictive performance of model.Twenty patients undergoing elective surgery received via TCI using model. The target effect-site concentrations (Ces) were 2.5, 3, 3.5, 4, 4.5, 2 μg/mL. Arterial blood samples obtained at least 10...

Abstract We characterized the volume kinetics of crystalloid solutions (Ringer’s lactate solution and 5% dextrose water) colloid (6% tetrastarch 10% pentastarch) by nonlinear mixed-effects modeling in healthy volunteers. also assessed whether bioelectrical impedance analysis parameters are significant covariates for kinetic parameters. Twelve male volunteers were randomly allocated to four groups, each group received fluid specified sequences, separated 1-week intervals avoid any carryover...

Although remifentanil is used widely by many clinicians during general anesthesia, there are recent evidences of opioid-induced hyperalgesia as an adverse effect. This study aimed to determine if intraoperative infusion caused increased pain the postoperative period in patients who underwent a thyroidectomy. A total 7511 aged ≥ 20 years, thyroidectomy between January 2009 and December 2013 at Asan Medical Center were retrospectively analyzed. Enrolled divided into 2 groups: group N (no only...

Background Although ultrasonography is recommended in internal jugular vein (IJV) catheterization, the landmark-guided technique should still be considered. The central landmark using two heads of sternocleidomastoid muscle widely used, but it inaccurate for IJV access. As an alternative landmark, we investigated accuracy new determined by inspection respiratory venodilation and direct palpation right access ultrasonography. Methods Findings Thirty patients were enrolled. After induction...

Conventional, intravenous, patient-controlled analgesia, which is only administered by demand bolus without basal continuous infusion, closely associated with inappropriate analgesia. Pharmacokinetic model-based dosing schemes can quantitatively describe the time course of drug effects and achieve optimal therapy. We compared efficacy safety a conventional regimen for intravenous analgesia that was infusion (group A) versus pharmacokinetic scheme performed decreasing dosage according to...

A thickened peroneus brevis tendon has been considered to be an important morphologic parameter of tendinitis (PBT). Previous researchers have found that the thickness (PBTT) is correlated with inflammation tendon. However, inflammatory hypertrophic change different from simple thickness. Thus, we devised cross-sectional area (PBTCSA) as a new diagnostic analyze hypertrophy whole PBT. We assumed PBTCSA major useful for early PBT diagnosis. Peroneus images were collected 22 patients and...

Carpal tunnel syndrome (CTS) is a common neuropathy. Although CTS progression known to be associated with thenar muscle (TM) atrophy, the diagnostic value of TM atrophy for has not been established. In this research, cross-sectional area (TMCSA) was evaluated analyze relationship between TMCSA and CTS. We assumed that major parameter in CTS.Both thickness (TMT) samples were acquired from 18 patients, control subjects who underwent wrist magnetic resonance imaging no evidence T2-weighted...

Suprascapular nerve entrapment (SNE) syndrome is a commonly overlooked cause of shoulder weakness and pain. It frequently causes over the posterior lateral aspects shoulder, as well pain infraspinatus muscles. Therefore, we considered that muscle cross-sectional area (IMCSA) might be new morphological parameter to analyze SNE syndrome. We assumed IMCSA an important morphologic in diagnosis. acquired data from 10 patients with healthy subjects who had undergone magnetic resonance imaging...

Thickening of the cervical ligamentum flavum (CLF) has been considered as a main cause spinal stenosis (CSS). A previous study reported that thickness (CLFT) is correlated with CSS. However, whole hypertrophy different from focal thickness. Therefore, to analyze CLF, we created new morphological parameter, called area (CLFA). We hypothesized CLFA an important parameter in diagnosis CLF samples were acquired 83 patients CSS, and 84 controls who underwent magnetic resonance imaging (C-MRI)....

Iliotibial band friction syndrome (ITBFS) is a common disorder of the lateral knee. Previous research has reported that iliotibial (ITB) thickness (ITBT) correlated with ITBFS, and ITBT been considered to be key morphologic parameter ITBFS. However, different from inflammatory hypertrophy. Thus, we made ITB cross-sectional area (ITBCSA) new morphological assess

One of major causes cervical central stenosis (CCS) is thickened change ligament flavum (CLF). The association a morphological parameter called thickness (CLFT) with CCS has not been reported yet. Thus, the purpose this research was to investigate relationship between and CFJT.Data were obtained from 88 patients CCS. A total 87 normal controls also underwent spine magnetic resonance imaging (CSMRI). All subjects axial T2-weighted CSMRI. Using our picture archiving communications system, at...

Carpal tunnel syndrome (CTS) is correlated with increased intracarpal canal pressure (ICP). The effect of palmaris longus tendon (PLT) loading on ICP documented in previous researches. PLT induces the greatest absolute increase ICP. Therefore, to analyze connection between and CTS, we newly made measurement cross-sectional area (PLTCSA). We assumed that PLTCSA a reliable diagnostic parameter CTS. data were acquired from 21 patients normal subjects who underwent wrist magnetic resonance...

Chondromalacia patella (CMP) is abnormal softening of the cartilage underside patella. It a cause anterior knee pain. Previous study has demonstrated that patellar hypertrophy correlated with early signs CMP (Grade 1 or 2). However, no studies have investigated clinical cutoff value hypertrophy. Thus, we devised cross-sectional area (PCCSA) as new predictive parameter for diagnosing CMP. The purpose this research was to compare MR measured PCCSA between patients and gender matched healthy...

There are various factors for the cause of cervical central stenosis (CCS), such as osteophyte, cervical-disc degeneration, and ligamentum flavum hypertrophy. However, pedicle vertebra has not yet been analyzed its relationship with CCS. We created a new morphologic parameter called cervical-pedicle thickness (CPT) to assess association between CCS pedicle. obtained morphological cases involving CPT from 82 patients were also 84 in normal group who underwent spine magnetic resonance imaging...

A narrowed sacroiliac joint (SIJ) space has been considered to be a major morphologic parameter of ankylosing spondylitis (AS). Previous studies revealed that the thickness (SIJT) correlated with AS in patients. However, irregular narrowing is different from thickness. Thus, we devised method using cross-sectional area (SIJA) as new morphological for use evaluating AS. We hypothesized SIJA key diagnosing SIJ samples were collected 107 patients AS, and 85 control subjects who underwent...

Glenohumeral joint (GHJ) space narrowing has been demonstrated to be an important morphologic parameter of glenohumeral osteoarthritis (GHO). However, the morphology GHJ is irregular because degeneration subchondral bone and articular cartilage. Thus, we devised cartilage cross-sectional area (GHJCCSA) as a new diagnostic morphological assess change GHJ. samples were acquired from 33 patients with GHO normal controls without evidence based on shoulder magnetic resonance imaging. T2-weighted...