A5107638277- Diabetes Treatment and Management
- Drug Transport and Resistance Mechanisms
- Potassium and Related Disorders
- Pancreatic function and diabetes
- Diabetes Management and Research
- Natural Antidiabetic Agents Studies
Daewoong Pharmaceutical (South Korea)
2024
Seoul National University Hospital
2006
To explore the effect of renal function on pharmacokinetic (PK) and pharmacodynamic (PD) profile safety enavogliflozin, a selective sodium-glucose cotransporter 2 (SGLT2) inhibitor, in patients with type diabetes mellitus (T2DM).
BACKGROUND Voglibose is alpha-glucosidase inhibitor. Due to negligible oral absorption, measuring drug concentration in the blood impractical. So we proposed pharmacodynamic assessment method reflect effect and this study aimed validate method. METHODS Placebo-controlled, selective two-period clinical was conducted 20 healthy male subjects. Period I: Subjects received a single dose of placebo on day 1. After min dosing, subjects had 400 kcal sucrose-rich fluid meal. Blood samples for...