The Korean Society of Nephrology (KSN) has maintained a nationwide end-stage renal disease (ESRD) registry data from Renal Data System (KORDS) since 1985, as the representative ESRD patients in Korea. This review is aimed to update status domestic and provide evidence on direction dialysis therapy.The KORDS Committee KSN collected centers through an online program, 1986 2019 were analyzed.The incidence prevalence Korea are increasing. population numbered more than 100,000 2019, doubling...

Objectives: The objective of this study was to evaluate the efficacy and tolerability blonanserin for treatment Korean patients with schizophrenia using a double-blind risperidone-compared design. Methods: Patients aged 18 65 years were randomly assigned or risperidone 8 weeks. assessed mean change in Positive Negative Syndrome Scale score total scores from baseline week 8. Safety assessments included monitoring vital signs, physical examination, laboratory tests, adverse events. Results: Of...

Adolescence is a time of social and cognitive development associated with changes in brain structure function. These developmental may show an altered path individuals born before 33 weeks' gestation (very preterm; VPT). The cerebellum affected by VPT birth, but no studies have yet assessed the adolescent this structure, or whether cerebellar are behavioural outcome. We measured volumes on structural magnetic resonance images 65 adolescents who were (VPT) 34 term-born (mean age = 15.09, SD...

Abstract This study aimed to compare health-related quality of life (HRQOL) over time in patients initiating hemodialysis (HD) or peritoneal dialysis (PD). A total 989 incident starting HD PD were included from a prospective nationwide cohort study. HRQOL was assessed 3, 12, and 24 months after the start dialysis. The scores questionnaires adjusted for clinical socioeconomic parameters. three on showed better eight end-stage renal disease (ESRD), physical component summary one mental domains...

Nafamostat mesilate (NM), a synthetic serine protease inhibitor, has been used increasingly as an anticoagulant during continuous renal replacement therapy (CRRT). However, there, are limited data from randomized studies on NM use in patients with bleeding tendency. This prospective study evaluated the efficacy and safety of CRRT acute kidney injury (AKI) at high risk bleeding. Patients AKI were into no (NA) groups. The primary outcome was treatment represented by filter lifespan. Several...

The outcome of coronavirus disease 2019 (COVID-19) is associated with organ damage; however, the information about relationship between acute kidney injury (AKI) and COVID-19 still rare. We evaluated clinical features prognosis patients AKI according to severity. Medical data hospitalized in two university-based hospitals during an outbreak Daegu, South Korea, were retrospectively analyzed. its severity defined Acute Kidney Injury Network. Of 164 COVID-19, 30 (18.3%) had AKI; 14, 4, 12 stage...

Acute rejection is hazardous to graft survival in kidney transplant recipients (KTRs). We aimed identify novel biomarkers for early diagnosis of acute T cell-mediated (TCMR) urinary exosomes KTRs.Among 458 biopsies enrolled a cross-sectional multicenter study, 22 patients with stable function (STA) who had not shown pathologic abnormality and 25 diagnosed biopsy-proven TCMR were analyzed. performed proteomic analysis using nano-ultra performance liquid chromatography-tandem mass spectrometry...

Abstract Medium cut-off (MCO) dialyzers help remove larger middle molecules associated with symptoms related to the accumulation of uremic retention solutes. We investigated effect an MCO dialyzer on improvement quality life (QOL) in maintenance hemodialysis (HD) patients. Forty-nine HD patients high-flux dialysis were randomly assigned either (Theranova 400, Baxter) or a (FX CorDiax 80 60, Fresenius Medical Care) and completed study. QOL was assessed at baseline after 12 weeks treatment...

Various vaccines against COVID-19 have been developed and proven to be effective, but their side effects, especially on kidney function, are not yet known in detail. In this study, we report the clinical courses histopathologic findings of new-onset diseases after vaccination as confirmed via biopsy. Five patients aged 42 77 years were included baseline function was normal all patients. The biopsy-proven diagnosis indicated newly diseases: (1) IgA nephropathy presenting with painless gross...

Patients with advanced chronic kidney disease (CKD) or who are on hemodialysis (HD) could have increased susceptibility to the 2019 coronavirus (COVID-19) given their pre-existing comorbidities, older age, compromised immune system, and regular visits populated outpatient dialysis centers. This study included 14 consecutive patients HD CKD initiated after being diagnosed laboratory-confirmed COVID-19 from February April 2020 in hospitals throughout Daegu, South Korea. The patients, 42.9% of...

Cerebellar ataxia, neuropathy, and vestibular areflexia syndrome (CANVAS) is a neurodegenerative disorder caused by biallelic expansion of pentanucleotide repeats in the <i>RFC1</i> gene. Previous studies have reported up to 22% patients with late-onset ataxia harbor this pathogenic repeat expansion. Despite its relatively high prevalence, CANVAS often underdiagnosed because disease not well recognized genetic testing performed clinical practice. Here, we present patient...

Expanded hemodialysis (HD) using a medium cut-off dialyzer improves the clearance of middle-molecular toxins compared to conventional HD. This study evaluated effect expanded HD on preserving residual kidney function in incident patients. Patients who initiated were randomized receive dialysis with either Theranova 400 (Baxter) or high-flux similar surface area over 12 months. The primary outcome was change glomerular filtration rate (GFR) months, as determined by mean urea and creatinine...

Abstract Background Hypokalemia can result from various causes, with diarrhea being one of the most common. Although rare, chronic hypokalemia lead to severe acute kidney injury (AKI) that requires dialysis. Therefore, this case study aims investigate a patient rectal cancer who, after concurrent chemoradiotherapy and ileostomy, developed owing prolonged diarrhea, leading AKI anuria. Case presentation A 64-year-old man history cancer, hypertension was admitted for He had due diarrhea....

Objective Smoking related cues may elicit smoking urges and psychophysiological responses in subjects with nicotine dependence. This study aimed to investigate the effect of repeated virtual cue exposure therapy using surround-screen based projection wall system on Methods The authors developed 3-dimensional neutral smoking-related environments reality (VR) technology. Smoking-related environment was a bar, which comprised both object-related social situation cues. Ten dependence...

Abstract Internet gaming disorder (IGD) leading to serious impairments in cognitive, psychological and social functions has gradually been increasing. However, very few studies conducted date have addressed issues related the event-related potential (ERP) patterns IGD. Identifying neurobiological characteristics of IGD is important elucidate pathophysiology this condition. P300 a useful ERP component for investigating electrophysiological features brain. The aims present study were...

Prealbumin, a sensitive marker for protein-energy status, is also known as an independent risk factor mortality in hemodialysis patients. We investigated the impact of prealbumin on survival incident peritoneal dialysis (PD) patients.In total, 136 PD patients (mean age, 53.0 ± 15.8 years) between 2002 and 2007 were enrolled study. Laboratory data, adequacy, nutritional parameters assessed 3 months after initiation. Patients classified into 2 groups according to level: high (≥ 40 mg/dL) low...

Abstract The response to erythropoiesis stimulating agents (ESAs) is affected by inflammation linked middle molecules in hemodialysis (HD) patients. We evaluated the effect of a medium cut-off (MCO) dialyzer on ESA resistance maintenance HD Forty-nine patients who underwent high-flux were randomly allocated MCO or group. primary outcome was changes erythropoietin index (ERI; U/kg/wk/g/dL) between baseline and 12 weeks. group showed significant decrease dose, weight-adjusted ERI compared at...

Hypercholesterolemia is reported to increase reactive oxygen species (ROS) and promote breast cancer progression. ROS play an important role in tumor biology, xanthine oxidase (XO) enzyme that generates ROS. The effects of febuxostat (FBX), XO inhibitor, on cell migration under LDL stimulation vitro metastasis associated with hypercholesterolemia vivo were studied. In vitro, FBX significantly inhibited LDL-induced production migration. Treatment small interfering RNA against was consistent...

The protective effects of nicotinamide adenine dinucleotide phosphate (NADPH) oxidase (NOX) 1 inhibition against kidney ischemia-reperfusion injury (IRI) remain uncertain. bilateral pedicles C57BL/6 mice were clamped for 30 min to induce IRI. Madin–Darby Canine Kidney (MDCK) cells incubated with H2O2 (1.4 mM) h oxidative stress. ML171, a selective NOX1 inhibitor, and siRNA treated inhibit NOX1. NOX expression, stress, apoptosis assay, mitogen-activated protein kinase (MAPK) pathway...

The worldwide incidence of renal disease diagnosed by a kidney biopsy varies with age, race, sex, and region. Owing to lack studies limited research resources for this in Korea, we investigated patterns analyzing data from biopsies performed over 13 years university-based teaching hospital Korea.Among 2,053 2001 2013 at Kyungpook National University Hospital, 1,924 were retrospectively analyzed histopathologic, demographic, clinical as well laboratory results.Among the studied biopsies,...

Acute rejection (AR) is critical for long-term graft survival in kidney transplant recipients (KTRs). This study aimed to evaluate the efficacy of integrated risk score omics-based biomarkers predicting AR KTRs. prospective, randomized, controlled, multicenter, pilot enrolled 40 patients who recently underwent high-immunologic-risk transplantation (KT). Five omics were measured, namely, blood mRNA (three-gene signature), urinary exosomal miRNA (six-gene and two proteins (hemopexin...

Abstract Epithelial-to-mesenchymal transition (EMT) is one of the main causes peritoneal fibrosis. However, pathophysiological mechanisms EMT, specifically its relationship with autophagy, are still unknown. This study aimed to evaluate role autophagy in transforming growth factor-beta 1 (TGF-β1)-induced EMT human mesothelial cells (HPMCs). Primary cultured HPMCs were treated TGF-β1 (2 and 5 ng/mL) changes markers between evaluated. We also identified EMT- autophagy-related signaling...