This study aimed to investigate variations in the phytochemical compound contents and antioxidant potential of ethanol rhizome extracts Smilax china L., belonging Liliaceae family, from different parts Korea, namely Uiwang (Mt. Gamnamugol), Gyeonggi Province (SC1); Geochang, Gyeongnam (SC2); Yeongwol, Gangwon (SC3); Chungju, Chungbuk (SC4). The phenolic flavonoid contents, radical scavenging activity, proximate composition samples were determined. total polyphenol content (TPC) ranged...

Aim: In this study, we investigated the effect of (−)-epigallocatechin-3-gallate (EGCG) on cyclic nucleotide production and vasodilator-stimulated phosphoprotein (VASP) phosphorylation in collagen (10 µg/mL)-stimulated platelet aggregation.Methods: Washed platelets (108/mL) from Sprague-Dawley rats (6-7 weeks old, male) were preincubated for 3 min at 37°C presence 2 mM exogenous CaCl2 with or without EGCG other materials, stimulated µg/mL) 5 min, then used determination intracellular...

Normal activation of platelets and their aggregation are crucial for proper hemostasis. It appears that excessive or abnormal may bring about cardiovascular diseases such as stroke, atherosclerosis, thrombosis. For this reason, finding a substance can regulate platelet suppress will aid in the prevention treatment diseases. Artesunate is compound extracted from plant roots

In this study, we investigated the effects of caffeic acid (CAFA), a phenolic acid, on Ca(2＋)-antagonistic cyclic nucleotides associated with phosphorylation inositol 1,4,5-trisphosphate receptor (IP3R) and vasodilator-stimulated phosphoprotein (VASP) thromboxane A2 (TXA2)-associated microsomal cyclooxygenase-1 (COX-1) activity in collagen (10 μg/mL)-stimulated platelet aggregation.Washed platelets (10(8)/mL) obtained from Sprague-Dawley rats (6-7 weeks old, male) were preincubated for 3...

Polyurethane foam (PUF) has generally been used in liquefied natural gas (LNG) carrier cargo containment systems (CCSs) owing to its excellent mechanical and thermal properties over a wide range of temperatures. An LNG CCS must be designed withstand extreme environmental conditions. However, as the insulation material for LNGC CCSs, PUF two major limitations: strength conductivity. In present study, PUFs were synthesized with various weight percentages porous silica aerogel reinforce...

Nurses with rotating shifts, including night have suffered from low physical activity during the COVID-19 pandemic and lower sleep quality due to disruption of their circadian rhythm. This study aimed develop examine effectiveness a mobile wellness program on daily steps, quality, exercise self-efficacy, intrinsic motivation for exercise, self-rated fatigue, wellness. A cluster randomized controlled trial design was used nurses shifts. Sixty one university hospital participated were...

The ability to inhibit aggregation has been demonstrated with synthetically derived ginsenoside compounds G-Rp (1, 3, and 4) ginsenosides naturally found in Panax ginseng 20(S)-Rg3, Rg6, F4, Ro. Among these compounds, Rk3 (G-Rk3) from needs be further explored order reveal the mechanisms of action during inhibition.Our study focused investigate G-Rk3 on agonist-stimulated human platelet aggregation, inhibition signaling molecules such as fibrinogen binding integrin αIIbβ3 using flow...

In this study, we investigated the effect of chlorogenic acid, a phenolic on collagen (10 μg/ml)-stimulated platelet aggregation. Chlorogenic acid dose-dependently inhibited collagen-induced aggregation, and suppressed production thromboxane A2 (TXA2), an intracellular Ca-agonist as aggregation-inducing autacoidal molecule, which was associated with strong inhibition cyclooxygenase (COX)-1 in microsomes having cytochrome c reductase activity. addition, increased significantly formation...

The root of Panax ginseng is used in ethnomedicine throughout eastern Asia and various recent studies have proved that has inhibitory effects on cardiovascular disease. Each factor causing disease known to a very complex process which achieved by diverse number mechanisms. Among these factors, platelets are the most important because they directly participate thrombogenesis. Therefore, inhibiting activity an essential element for prevention diseases. Our previous study showed antiplatelet...

Synthetic ginsenoside compounds G-Rp (1,3, and 4) natural ginsenosides in Panax ginseng 20(S)-Rg3, Rg6, F4 Ro have inhibitory actions on human platelets. However, the mechanism of Rk1 (G-Rk1) is still unclear thus, we initiated investigation anti-platelet by G-Rk1 from ginseng. Our study focused to investigate action agonist-stimulated platelet aggregation, inhibition signaling molecules such as fibrinogen binding with integrin αIIbβ3 using flow cytometry, intracellular calcium mobilization,...

Normal activation of platelets and their aggregation are crucial during hemostasis process.It appears excessive or abnormal may bring about cardiovascular diseases like stroke, atherosclerosis, thrombosis.For this reason, finding a substance that can regulate platelet suppress will aid in the prevention treatment diseases.Artemisinin, compound derived from Artemisia Scopolia plants, has shown potential various areas such as anticancer Alzheimer's disease research.However, specific role...

Panax ginseng (P. ginseng), one of the most valuable medicinal plants, is known for its healing and immunobooster properties has been widely used in folk medicine against cardiovascular diseases, including stroke heart attack. In this study, we explored anti-platelet activity gintonin (a recently discovered non-saponin fraction ginseng) agonist-induced platelet activation. vitro effects on human rat aggregation, granule secretion, integrin αIIbβ3 activation, intracellular calcium ion...

The prevalence of cardiovascular diseases (CVDs) is increasing at a high rate, and the available treatment options, sometimes, have complications which necessitates need to develop safer efficacious approaches. Ethnomedicinal applications reportedly reduce CVD risk. Ulmus parvifolia Jacq. (Ulmaceae) commonly known as Chinese Elm or Lacebark Elm, native China, Japan, Korea. It exhibits anti-inflammatory, antiviral, anticancer properties, but its anti-platelet properties not yet been...

This paper describes the design, synthesis, and biological evaluation of a novel anti-ischemic compound, (2S,3S,4R)-N-(6-amino-3,4-dihydro-2-dimethoxymethyl-3-hydroxy-2-methyl-2H-benzopyranyl)-N'-benzyl-N''-cyanoguanidine (33), structure−activity relationships leading to discovery this compound. Compound 33 significantly reduced myocardial infarct zone area at risk (IZ/AAR) in ischemic myocardium rat model with high cardioselectivity. Since cardioprotective effect compound is reversed by...

Intracellular Ca(2+) ([Ca(2+)] i ) is platelet aggregation-inducing molecule and involved in activation of aggregation associated molecules. This study was carried out to understand the Ca(2+)-antagonistic effect ginsenoside Ro (G-Ro), an oleanane-type saponin Panax ginseng. G-Ro, without affecting leakage lactate dehydrogenase, dose-dependently inhibited thrombin-induced aggregation, half maximal inhibitory concentration approximately 155 μM. G-Ro strongly thrombin-elevated [Ca(2+)] , which...

Background and Objective. Epimedium koreanum Nakai is a medicinal plant known for its health beneficial effects on impotence, arrhythmia, oxidation, aging, osteoporosis, cardiovascular diseases. However, there no report available that shows platelet functions. Here, we elucidated antiplatelet antithrombotic of ethyl acetate fraction E. koreanum. Methodology. We analyzed the properties using standard in vitro vivo techniques, such as light transmission aggregometry, scanning electron...