A5019449255- Renal Transplantation Outcomes and Treatments
- Dialysis and Renal Disease Management
- Renal Diseases and Glomerulopathies
- Acute Kidney Injury Research
- Parathyroid Disorders and Treatments
- Organ Transplantation Techniques and Outcomes
- Chronic Kidney Disease and Diabetes
- Pharmacological Effects and Toxicity Studies
- Organ Donation and Transplantation
- Transplantation: Methods and Outcomes
- Neurological Complications and Syndromes
- Cytomegalovirus and herpesvirus research
- Central Venous Catheters and Hemodialysis
- Renal and Vascular Pathologies
- Cardiovascular and Diving-Related Complications
- Blood groups and transfusion
- Hematopoietic Stem Cell Transplantation
- Adenosine and Purinergic Signaling
- Trauma, Hemostasis, Coagulopathy, Resuscitation
- Pneumocystis jirovecii pneumonia detection and treatment
- Immune Cell Function and Interaction
- Iron Metabolism and Disorders
- Health Systems, Economic Evaluations, Quality of Life
- Electrolyte and hormonal disorders
- Thermoregulation and physiological responses
Eunpyeong Hospital
2020-2025
Catholic University of Korea
2013-2025
Kyungpook National University
2011-2024
Kyungpook National University Hospital
2022-2024
Seoul St. Mary's Hospital
2015-2024
The Yeats Society of Korea
2015
YKK (Japan)
2015
Stadtwerke Köln (Germany)
2015
Yonsei University
1972
Abstract Background The revised 2023 guidelines from the International Society for Peritoneal Dialysis (ISPD) emphasize salvage methods treating refractory catheter-related infections, or mechanical catheter damage. This approach preserves existing by manipulating only outer cuff above peritoneum, avoiding hemodialysis transfer. We investigated effectiveness of partial replantation technique. Methods In this retrospective single-center study (January 2021 - December 2023), outcomes nine...
While high serum phosphorus levels have been related to adverse outcomes in hemodialysis patients, further investigation is warranted persons receiving peritoneal dialysis (PD).Longitudinal data (2014-17) from the Peritoneal Dialysis Outcomes and Practice Patterns Study (PDOPPS), a prospective cohort study, were used examine associations of with all-cause mortality major cardiovascular events via Cox regression adjusted for confounders. Serum parameterized by four methods: (i) baseline...
Mineral bone disorder (MBD) in chronic kidney disease (CKD) is associated with high symptom burden, fractures, vascular calcification, cardiovascular and increased morbidity mortality. CKD-MBD studies have been limited peritoneal dialysis (PD) patients. Here, we describe calcium parathyroid hormone (PTH) control, related treatments mortality associations PD
Introduction The aim of this study is to investigate the clinical validity donor-derived cell-free DNA (dd-cfDNA) in comparison with that donor specific anti-HLA antibody (DSA) for predicting biopsy-proven rejection (BPR)and severe microvascular inflammation (severe MVI) kidney transplant recipients (KTRs). Methods In prospective observational investigation, 64 KTRs who underwent indicated biopsies were included. Blood samples collected prior biopsy tested dd-cfDNA and DSA. Biopsy specimens...
Whether the coexistence of anti-A/B antibody and donor specific anti-HLA (HLA-DSA) has a synergistic impact on development acute antibody-mediated rejection (AAMR) in kidney transplant recipients (KTRs) is unclear. This study includes 92 KTRs who received from an ABO-incompatible (ABOi) or were presensitized to HLA (HLAs) 292 controls (CONT). HLAs was defined as crossmatch positivity presence HLA-DSA. We compared incidence AAMR among ABOi (n = 58), ABOi+HLAs 12), 22), CONT 292) groups...
The association between dialysate calcium (DCa) concentration and mortality in hemodialysis (HD) patients is controversial. In this study, we evaluated the impact of DCa on incident HD patient. Incident were selected from Clinical Research Center registry—a prospective cohort study dialysis Korea. Patients categorized into 3 groups according to prescribed at time enrollment. High was defined as a 3.5 mEq/L, mid-DCa 3.0 low 2.5 2.6 mEq/L. primary outcome all-cause secondary outcomes...
We sought to assess the relationship between retinal nonperfusion area (NPA) on ultra-widefield fluorescein angiography (UWFA) and renal function in type 2 diabetes mellitus (DM) patients with diabetic retinopathy (DR) nephropathy.UWFA was performed 248 eyes (124 patients) DR, comprising 94 from chronic kidney disease (CKD) caused by 154 without CKD (non-CKD). Serum creatinine level (Cr), estimated glomerular filtration rate (eGFR), urine albumin/creatinine ratio (UACR), protein/creatinine...
Several studies reported the effect of obesity on progression IgA nephropathy (IgAN). However, impact clinicopathologic presentation IgAN remains uncertain. This is a retrospective cross-sectional study from eight university hospitals in South Korea. Patients were categorized into three groups using Asia-Pacific classification based body mass index (BMI). Clinical and histopathologic data at time renal biopsy analyzed. Among 537 patients with IgAN, obese group was more hypertensive had lower...
BACKGROUND:This randomized controlled trial aimed to investigate the effect of everolimus (EVL) with low-dose tacrolimus (Tac) on development post-transplantation diabetes mellitus (PTDM) in kidney transplantation (KT). MATERIAL AND METHODS:Seventy-seven transplant patients from 4 centers were included. Patients "EVL group" (n=38) and "TAC (n=39). The target Tac trough level was 2 5 ng/mL EVL group 10 TAC group. RESULTS:The 1-year cumulative incidence PTDM all 7.8%, no difference found...
Development of tumor lysis syndrome (TLS) may occur after chemotherapy or spontaneously in bulky rapidly growing tumors. This is frequent but preventable patients with hematologic malignancies. TLS following therapy has been reported infrequently various types solid associated oxaliplatin containing a never reported. A 59-year-old man received 5-fluorouracil, leucovorin, and (FOLFOX) for metastatic colon cancer. occurred three days administration chemotherapy. Two later, his abnormal...
This study aimed to determine the impact of tacrolimus (TAC) trough level (C0) intrapatient variability (IPV) over a period 2 years after kidney transplantation (KT) on allograft outcomes. In total, 1,143 patients with low immunologic risk were enrolled. The time-weighted coefficient (TWCV) TAC-C0 was calculated, and divided into tertile groups (T1: < 24.6%, T2: 24.6%–33.7%, T3: ≥ 33.7%) according TAC-C0-TWCV up post-transplant 1 st year. They classified low/low, low/high, high/low,...
Clinical trials of biologic agents for chronic active antibody-mediated rejection (CAMR) in kidney transplant recipients (KTRs) have been disappointing. We performed a clinical trial mesenchymal stem cell (MSC) treatment KTRs with CAMR unresponsive to rituximab and intravenous immunoglobulin. This study was phase 1 confirm patient safety. Two patients immunoglobulin were included. Each received allogeneic MSCs 4 cycles ( <a:math xmlns:a="http://www.w3.org/1998/Math/MathML" id="M1">...
Hyperuricemia is a significant risk factor for cardiovascular morbidity and chronic kidney disease progression. IgA nephropathy (IgAN) well-known primary glomerular nephropathy. associated with poor prognosis in IgAN patients. We evaluated the association of hyperuricemia histopathological severity male female patients; 658 patients diagnosed via biopsy were initially included. Baseline patient data collected by eight university hospitals affiliated College Medicine Catholic University...
Abstract Pericytes are mesenchymal cells that surround endothelial cells, playing a crucial role in angiogenesis and vessel maturation. Additionally, they associated with interstitial fibrosis as major contributor to renal myofibroblasts. In this study, we aim investigate whether the phosphodiesterase inhibitor, pentoxifylline (PTX), can ameliorate aging‐related functional histological deterioration kidney. We subjected aging C57BL/6 mice, dividing into young, aging, PTX‐treated groups....
Whether advanced age is associated with poor outcomes of elderly patients acute kidney injury (AKI) requiring continuous renal replacement therapy (CRRT) controversial. This study aimed to evaluate effect and predictors for mortality in AKI undergoing CRRT.
Continuous renal replacement therapy (CRRT) has become the standard modality of (RRT) in critically ill patients. However, consensus is lacking regarding criteria for discontinuing CRRT. Here we validated usefulness prediction model successful discontinuation CRRT a multicenter retrospective cohort.
IgA nephropathy (IgAN) is a globally well-known primary glomerular nephropathy. Hypertriglyceridemia (HTG) one factor contributing to atherosclerosis and common complication of renal failure. HTG significant risk for decreased function in patients with IgAN. We evaluated the association histopathological features IgAN patients. A total 480 diagnosed via kidney biopsy from eight university hospitals affiliated College Medicine Catholic University Korea were included final cohort. Pathological...
Cardiovascular disease is the most common cause of sickness and death for long-term kidney transplant recipients, dyslipidemia an important risk factor developing cardiovascular disease. Lipid-lowering strategies, with use statins, have been shown to reduce risks related dyslipidemia, but concomitant 3-hydroxy-3-methylglutaryl coenzyme A reductase inhibitors immunosuppressive agents may increase rhabdomyolysis owing a drug-drug interaction. We report case simvastatin-induced acute injury...
<i>Background:</i> It has been demonstrated that phosphate uptake through the type III sodium-dependent co-transporter, Pit-1, induced apoptosis of aortic vascular smooth muscle cells and endothelial in vitro. However, apoptotic effects high (HP) level human peritoneal mesothelial (HPMCs) are not known. <i>Methods:</i> To examine whether Pit-1 is expressed HPMCs, we checked Western blot assay immunoreactive transcription by reverse transcriptase PCR. We treated...
Infection is the second leading cause of death in patients undergoing long-term dialysis. Peritoneal dialysis (PD) associated with an increased risk infection-related hospitalization (IRH) when compared hemodialysis. In this study, we investigated influence IRH on clinical outcomes incident PD patients.In total, 583 were selected from Clinical Research Center Registry for End-Stage Renal Disease, a nationwide multicenter prospective observational cohort study Korea. Incident who had been...
Dipeptidyl peptidase 4 (DPP-4) inhibitors exert pleiotropic effects beyond glycemic control.We investigated the renoprotective of DPP-4 on aging mice mediated by renin-angiotensin system (RAS).C57BL/6 were divided into three groups: two-month-old (YM group), eighteenmonth-old (AM group) and eighteen-month-old, linagliptin-treated + LIN group).Renal function was improved, based serum creatinine cystatin-C levels (p < 0.05 compared with AM group for both parameters).Fibrotic areas proteins...
The increasing load of senescent cells is a source aging, and chronic inflammation plays pivotal role in cellular senescence. In addition, renal tubular epithelial are closely associated with aging. Lysophosphatidic acid (LPA) bioactive lipid mainly produced by the catalytic action autotaxin (ATX), its ligation to LPA receptor-1 (LPAR1) fibrosis; however, aging unclear. Male 2-, 12-, 24-month-old C57BL/6 mice Human proximal (HRPTEpiC) were used present study. DNA damage oxidative...