A5068334327- Genetic Associations and Epidemiology
- Spaceflight effects on biology
- Tissue Engineering and Regenerative Medicine
- 3D Printing in Biomedical Research
- RNA modifications and cancer
- Genetic Mapping and Diversity in Plants and Animals
- Genetic and phenotypic traits in livestock
- Epigenetics and DNA Methylation
- Cancer-related molecular mechanisms research
- Electrospun Nanofibers in Biomedical Applications
- Radiation Therapy and Dosimetry
- Medical and Biological Ozone Research
- High Altitude and Hypoxia
- Bioinformatics and Genomic Networks
- Cancer-related gene regulation
- Hormonal Regulation and Hypertension
- Genomics, phytochemicals, and oxidative stress
- Metabolism, Diabetes, and Cancer
- Effects of Radiation Exposure
- Menopause: Health Impacts and Treatments
- Cardiovascular Disease and Adiposity
- Thermoregulation and physiological responses
- Tracheal and airway disorders
- Veterinary medicine and infectious diseases
- Cancer Cells and Metastasis
Ghent University
2021-2024
University of South Carolina
2024
Belgian Nuclear Research Centre
2021-2024
Maastricht University
2024
Lund University
2021-2022
Center for Excellence in Brain Science and Intelligence Technology
2018
Karolinska Institutet
2010-2017
Epigenomics (Germany)
2013
Stockholm University
2010
Non-Hodgkin lymphoma (NHL) represents a diverse group of hematological malignancies, which follicular (FL) is prevalent subtype. A previous genome-wide association study has established marker, rs10484561 in the human leukocyte antigen (HLA) class II region on 6p21.32 associated with increased FL risk. Here, three-stage study, starting scan 379 cases and 791 controls followed by validation 1,049 5,790 controls, we identified second independent FL–associated locus 6p21.32, rs2647012...
Recent development of personal sequencers for extensive mutation analysis and bead array technology comprehensive DNA methylation have made it possible to obtain integrated pictures genetic epigenetic alterations on the same set cancer samples. Here, we aimed establish such gastric cancers (GCs). Comprehensive 30 GCs revealed that number aberrantly methylated genes was highly variable among individual GCs. Extensive 55 known cancer-related 19 had 24 somatic mutations eight different (CDH1,...
Human spaceflight is associated with several health-related issues as a result of long-term exposure to microgravity, ionizing radiation, and higher levels psychological stress. Frequent reported skin problems in space include rashes, itches, delayed wound healing. Access restricted by financial logistical issues; consequence, experimental sample sizes are often small, which limits the generalization results. Earth-based simulation models can be used investigate cellular responses certain...
Abstract Background Aberrant DNA methylation is induced by aging and chronic inflammation in normal tissues. The induction widely recognized as acceleration of age-related methylation. However, few studies addressed target genomic regions the responsible factors a genome-wide manner. Here, we analyzed targets inflammation, taking advantage potent human gastric mucosa Helicobacter pylori infection-triggered inflammation. Results microarray analysis 482,421 CpG probes, grouped into 270,249...
Abstract Bioprinting in space is the next frontier tissue engineering. In absence of gravity, novel opportunities arise, as well new challenges. The cardiovascular system needs particular attention engineering, not only to develop safe countermeasures for astronauts future deep and long‐term missions, but also bring solutions organ transplantation shortage. this perspective, challenges encountered when using bioprinting techniques current gaps that need be overcome are discussed. recent...
Abstract Without the protective shielding of Earth’s atmosphere, astronauts face higher doses ionizing radiation in space, causing serious health concerns. Highly charged and high energy (HZE) particles are particularly effective complex difficult-to-repair DNA double-strand breaks compared to low linear transfer. Additionally, chronic cortisol exposure during spaceflight raises further concerns, although its specific impact on damage repair remains unknown. This study explorers effect...
Loss of caudal-type homeobox transcription factor 2 (CDX2) expression in colorectal cancers (CRCs) has recently been proposed as a promising predictive biomarker for not only prognosis but also response to chemotherapy. However, the relationship between alterations CDX2 during cancer progression and chemotherapy remains unclear. We herein aimed determine concordance primary CRCs corresponding liver metastases, association with chemotherapy.Primary exhibited heterogeneous expression. Seven...
Abstract Mechanical ventilation is often required in patients with pulmonary disease to maintain adequate gas exchange. Despite improved knowledge regarding the risks of over ventilating lung, ventilator induced lung injury (VILI) remains a major clinical problem due inhomogeneities within diseased itself as well need increase pressure or volume oxygen life-saving measure. VILI characterized by increased physical forces exerted which results cell death, inflammation and long-term fibrotic...
Introduction The immune system is an intricate network of cellular components that safeguards against pathogens and aberrant cells, with CD4+ T cells playing a central role in this process. Human space travel presents unique health challenges, such as heavy ion ionizing radiation, microgravity, psychological stress, which can collectively impede function. aim research was to examine the consequences simulated stressors on cell activation, cytokine production, gene expression. Methods were...
Human presence in space has uncovered several health concerns related to the environment that need be addressed for future missions. The hostile includes radiation and microgravity cause various pathophysiological effects. Among them are conditions cardiovascular system. system shows a dysfunctional deconditioning state, similar ageing on Earth, once exposed environment. As we aim longer missions Moon, Mars, thus into deep space, better understanding, monitoring, development of...
<b>Background and aims:</b> The majority of current organoids are grown within Matrigel, a protein mixture secreted by mouse sarcoma cells, due to the fact that it mimics basement membrane contains growth factors support organoid formation. However, concerns have arisen as suitability Matrigel for studying normal regeneration stem cell behavior its cancerous origin. Hydrogels generated from pepsin extracted, decellularized extracellular matrix (dECM) solutions recently emerged potential...
Living in space is not as simple living on Earth. The environment harmful for humans. Astronauts experience weightlessness and are exposed to dangerous radiation. On top of that, astronauts live a tiny area, far from their loved ones. All our organs harmed by these factors. heart, example, starts age much quicker than This means that have higher risk heart disease after going space. It therefore important we investigate why this happens so can prevent it. In the past, studies were based...
Abstract. Changes in morphology within the biostratigraphically important Oligocene nannofossil lineage, Sphenolithus predistentus, S. distentus and ciperoensis were investigated carbonate sediments from palaeo-equatorial Pacific Ocean Site 1218 order to determine nature of this evolutionary lineage. Using differences their stratigraphical ranges, aim study was whether these taxa represent an anagenetic lineage or a set discrete species with overlapping ranges. A total 1215 specimens 12...
Bioprinting in Space 3D bioprinting space is the next frontier for tissue engineering and already being explored by several agencies companies. With this cover, Kevin Tabury, Lorenzo Moroni, co-workers illustrate future hopes to print whole organs applications on Earth space. This perspective (article 2203338) provides current state of cardiac