A5032209960- Spaceflight effects on biology
- Medical and Biological Ozone Research
- DNA Repair Mechanisms
- Genetics, Aging, and Longevity in Model Organisms
- Radiation Therapy and Dosimetry
- Thermoregulation and physiological responses
- Tendon Structure and Treatment
- Effects of Radiation Exposure
- Cellular Mechanics and Interactions
- Wound Healing and Treatments
Belgian Nuclear Research Centre
2023-2024
Fibroblast migration is an important aspect of wound healing. Different factors can influence and as such proper In vitro scratch assays are used to examine cellular migration. However, the wide array techniques available reduces reproducibility findings. this paper, we compare two for creation; i.e. exclusion method or scratching cell monolayers. Furthermore, investigate if analysis software influences experimental outcome by comparing both commercially freely software. Besides, effect...
Human spaceflight is associated with several health-related issues as a result of long-term exposure to microgravity, ionizing radiation, and higher levels psychological stress. Frequent reported skin problems in space include rashes, itches, delayed wound healing. Access restricted by financial logistical issues; consequence, experimental sample sizes are often small, which limits the generalization results. Earth-based simulation models can be used investigate cellular responses certain...
Abstract The spaceflight environment imposes risks for maintaining a healthy skin function as the observed delayed wound healing can contribute to increased of infection. To counteract in space, better understanding fibroblasts’ reaction altered gravity levels is needed. In this paper, we describe experiments that were carried out at Large Diameter Centrifuge located ESA-ESTEC part ESA Academy 2021 Spin Your Thesis! Campaign. We exposed dermal fibroblasts set levels, including transitions...
Abstract Without the protective shielding of Earth’s atmosphere, astronauts face higher doses ionizing radiation in space, causing serious health concerns. Highly charged and high energy (HZE) particles are particularly effective complex difficult-to-repair DNA double-strand breaks compared to low linear transfer. Additionally, chronic cortisol exposure during spaceflight raises further concerns, although its specific impact on damage repair remains unknown. This study explorers effect...