A5101485057- Technology and Data Analysis
- Peroxisome Proliferator-Activated Receptors
- Nitric Oxide and Endothelin Effects
- Genetic factors in colorectal cancer
- Erythrocyte Function and Pathophysiology
- Biological Activity of Diterpenoids and Biflavonoids
- Cancer, Lipids, and Metabolism
- Cancer Genomics and Diagnostics
- Cardiomyopathy and Myosin Studies
- Electron Spin Resonance Studies
- Virology and Viral Diseases
- Bacterial Identification and Susceptibility Testing
- MicroRNA in disease regulation
- Heart Rate Variability and Autonomic Control
- Epilepsy research and treatment
- Sulfur Compounds in Biology
- Nicotinic Acetylcholine Receptors Study
- Glycosylation and Glycoproteins Research
- Urinary Tract Infections Management
- Muscle Physiology and Disorders
- Blood properties and coagulation
- Diverse Approaches in Healthcare and Education Studies
- S100 Proteins and Annexins
- Antibiotic Resistance in Bacteria
- Cardiac Health and Mental Health
Seoul St. Mary's Hospital
2019-2024
Catholic University of Korea
2013-2024
Daejeon St. Mary's Hospital
2008-2024
Keimyung University
2023
Weatherford College
2022
Laboratoire de Biochimie
2016
University of California, San Diego
2014-2015
Cheil General Hospital and Women's Healthcare Center
2015
Women’s Health Care
2014
Bayer (United States)
2014
Initiation of translation the RNA genomes picornaviruses such as poliovirus and encephalomyocarditis virus is cap-independent results from interaction ribosomes with a segment 5' noncoding region these mRNAs termed internal ribosomal entry site. Genetic biochemical studies have previously shown that 57-kDa cytoplasmic RNA-binding protein (p57) plays an essential role in this mechanism. We now found p57 shares physical, biochemical, antigenic properties pyrimidine tract-binding (PTB), nuclear...
Hyeyoung Lee , M.D., Ji Hyeong Ryu B.S., Hye-Sun Park M.S., Ki Hyun Hyunjoo Bae Sojeong Yun Ae-Ran Choi Sung-Yeon Cho Chulmin Ph.D., Dong-Gun Jihyang Lim Jehoon Seungok Soyoung Shin Haeil and Eun-Jee Oh M.D.. Ann Lab Med 2019;39:566-71. https://doi.org/10.3343/alm.2019.39.6.566
We investigated the effects of amitriptyline, a tricyclic antidepressant, on [3H]norepinephrine ([3H]NE) secretion and ion flux in bovine adrenal chromaffin cells. Amitriptyline inhibited [3H]NE induced by 1,1-dimethyl-4-phenylpiperazinium iodide (DMPP) 70 mM K+. The half maximal inhibitory concentration (IC50) was 2 μM 9 μM, respectively. also elevation cytosolic calcium ([Ca2+]i) DMPP K+ with IC50 values 1.1 35 rises sodium ([Na+]i) [Ca2+]i Na+ channel activator veratridine were...
Immunomodulatory or immunosuppressive properties of bone marrow-derived mesenchymal stem cells (BM-MSCs) facilitate the treatment acute respiratory distress syndrome and lung injury (ALI). Dysregulated miRNA (miRNA miR) expression associated with effects BM-MSCs was assessed in a rat model lipopolysaccharide (LPS)-induced ALI. The present study performed biochemical tests to assess five analytes, including alanine aminotransferase (ALT), aspartate (AST), lactate, blood urea nitrogen (BUN),...
We evaluated growth performance of the BacT/ALERT VIRTUO and BACTEC FX blood culture (BC) systems based on recovery rate time to detect microorganisms under simulated bloodstream infection conditions.Three expected concentrations 125, 30, 5 CFU/mL eighteen reference were diluted with mL for adult aerobic/anaerobic 3 pediatric aerobic inoculated, each three BC bottles loaded into two systems.A total 405 comparative analyzed in this study. The percent agreement between BacT/ ALERT after...
Carbapenemase-producing Enterobacterales (CPE) poses a significant challenge to infection control in healthcare settings. Active screening is recommended prevent intra-hospital CPE transmission. was initiated at 660-bed hospital South Korea September 2018, targeting patients previously colonized/infected or admitted outside facilities (HCFs) within 1 month. Universal intensive care unit (ICU) performed the time of admission. After hospital-wide outbreak July-September 2019, program enhanced...
College of Pharmacy, Chosun University, Gwangju 501-759, KoreaReceived May 12, 2012, Accepted 26, 2012Amentoflavone is naturally occurring bioflavonoid that found in a number plants. In this paper, the anti-inflammatory activity amentoflavone LPS-stimulated macrophages and its mode action wereexamined. Using RAW264.7 macrophage cells, we exerted activities through inhibition nitric oxide (NO) production tumor necrosis factor (TNF)- αand inflammatory protein (MIP)-2 secretion. Amentoflavone...
During the measles epidemic in 2019, in-hospital transmission of contributed to more than two-thirds cases South Korea, where is declared eliminated. This study aimed examine seropositivity among healthcare workers (HCWs) Korea help develop an effective prevention strategy for hospital settings. Measles IgG titer was tested 1,579 HCWs working a university-affiliated and measles-containing vaccine (MCV) immunization records 870 were identified. The overall 92.0%, but antibody titers...
We conducted in silico screening for human peroxisome proliferator-activated receptor gamma (hPPARgamma) by performing an automated docking study with 450 flavonoids. Among the eight flavonoids as possible agonists of hPPARgamma, only 3,6-dihydroxyflavone (4) increased binding between PPARgamma and steroid coactivator-1 (SRC-1), approximately 5-fold, showed one order higher affinity than a reference compound, indomethacin. The 6-hydroxy group A-ring participated hydrogen-bonding interactions...
Comprehensive assessment of SARS-CoV-2 antibodies against antigenic epitopes and cross-neutralization on variants is essential to monitor after infection or vaccination. From 32 COVID-19 patients 40 vaccinated individuals [20 Oxford–AstraZeneca (AZ) 20 Pfizer–BioNTech (BNT)], 348 serial sera are collected until days 3 months homologous booster Antibody levels were monitored using a multiplex-bead assay including variant spike antigens, Roche (S1/RBD total) surrogate virus neutralization test...
Human peroxisome proliferator-activated receptor gamma (<TEX>$hPPAR{\gamma}$</TEX>) has been implicated in numerous pathologies, including obesity, diabetes, and cancer. Previously, we verified that amentoflavone is an activator of <TEX>$hPPAR{\gamma}$</TEX> probed the molecular basis its action. In this study, investigated mechanism action cancer cells demonstrated showed strong cytotoxicity against MCF-7 HeLa cell lines. We expression specifically stimulated by amentoflavone, suggested...
MAGnificent analysis to remove ambiguity: The binding epitopes of tri- and tetrasaccharide ligands in their interactions with the myelin-associated glycoprotein (MAG) have been studied by using saturation transfer difference NMR, which signal intensities can help resolve overlapped HSQC signals. In figure, signals protons closest proximity protein are shown red (30–60 %) or blue (61–100 %). Detailed facts importance specialist readers published as ”Supporting Information”. Such documents...
In studies of the molecular basis gastric cancer (GC), microsatellite instability (MSI) is one key factors. Somatic mutations found in GC are expected to contribute MSI-high (H) tumorigenesis. We estimated somatic mutation distribution according MSI status 52 matched pair samples using Ion Torrent S5 XL with AmpliSeq Cancer Hotspot panel. Seventy-five (9.8%) variants consisting 34 hotspot and 41 other likely pathogenic were identified samples. The TP53 was most common (35%, 26/75), followed...
We designed and evaluated the suitability of three customized microsatellite instability (MSI) panels using a combination mono- dinucleotide markers to improve detection MSI status in 56 matched normal gastric cancer specimens.An analysis was performed optimize panel detect two different panels: (1) mononucleotide marker consisting BAT25, BAT26, BAT40, BAT-RII, NR21, NR22, NR24, NR27 (2) containing D2S123, D5S346, D17S250, D17S261, D17S520, D18S34, D18S58. The consisted five, seven, or ten...
Gastrointestinal stromal tumors (GISTs) frequently harbor activating gene mutations in either KIT or platelet-derived growth factor receptor A (PDGFRA) and are highly responsive to several selective tyrosine kinase inhibitors. In this study, a targeted next-generation sequencing (NGS) assay with an Oncomine Focus Assay (OFA) panel was used for the genetic characterization of molecular targets 30 Korean patients GIST.Using OFA that enables rapid simultaneous detection hotspots, single...
To report a case with unusual ABO discrepancies caused by coexistence of the loss anti-B isoagglutinin and rouleau formation.A 79-year-old female diagnosed as having multiple myeloma (MM) monoclonal IgG-λ type showed formation in peripheral blood smear. The Rh before diagnosis MM was A+, but following grouping interpreted AB+. genotype revealed subtypes A102 O101, which confirmed her phenotype A+.This combined group I III mimicking AB.