Tom Alsaigh

ORCID: 0009-0003-1037-302X
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About
Contact & Profiles
Research Areas
  • Erythrocyte Function and Pathophysiology
  • Immune cells in cancer
  • Phagocytosis and Immune Regulation

Stanford University
2024

Atherosclerosis is an inflammatory disorder responsible for cardiovascular disease. Reactivation of efferocytosis, the phagocytic removal cells by macrophages, has emerged as a translational target atherosclerosis. Systemic blockade key 'don't-eat-me' molecule, CD47, triggers engulfment apoptotic vascular tissue and potently reduces plaque burden. However, it also induces red blood cell clearance, leading to anemia. To overcome this, we previously developed macrophage-specific nanotherapy...

10.1038/s41467-024-52005-1 article EN cc-by-nc-nd Nature Communications 2024-09-13
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