A5107351250- Metabolism and Genetic Disorders
- Genetic Associations and Epidemiology
- Obstructive Sleep Apnea Research
- Drug-Induced Hepatotoxicity and Protection
- Immunotoxicology and immune responses
- Fibroblast Growth Factor Research
- Mitochondrial Function and Pathology
- High Altitude and Hypoxia
- Virus-based gene therapy research
- Genomic variations and chromosomal abnormalities
- Medical Case Reports and Studies
- Diet and metabolism studies
- Eosinophilic Disorders and Syndromes
- Genomics and Rare Diseases
- Proteoglycans and glycosaminoglycans research
- Alcohol Consumption and Health Effects
- Neuroscience of respiration and sleep
- Metabolomics and Mass Spectrometry Studies
- Viral Infectious Diseases and Gene Expression in Insects
- Substance Abuse Treatment and Outcomes
- Amino Acid Enzymes and Metabolism
Fundación Neumológica Colombiana
2025
Servicio Gallego de Salud
2018
Universidad de La Laguna
1998-2010
Abstract Introduction At high altitudes, hypobaric hypoxia leads to central apneas in both healthy adults and patients with obstructive sleep apnea. This condition correlates intermittent desaturation disruption of sleep. Materials Methods The clinical case a patient evaluated during medicine outpatient consultation at the Fundación Neumológica Colombiana (Bogotá, Colombia, 2,600 masl) is reported. Case Study We present 64-year-old male living high-altitude city, who was an aircrew member on...
By virtue of the functional role mitochondrion in energy and reactive oxygen species production, mutations mitochondrial DNA (mtDNA) are potential candidates for cardiovascular-related disorders. Further, mtDNA is extremely polymorphic several diagnostic single-nucleotide polymorphisms have been used to assort sequences into haplogroups with defined continental regional ranges. However, relevance these respect coronary artery disease (CAD) susceptibility remains unclear. In this study, we...
The development of specific antibody probes for characterizing the expression family 4 fibroblast growth factor receptor (FGFR) types has been difficult because their close homology to each other and high degree evolutionary conservation. Of existing anti-FGFR monoclonal antibodies (MAbs), there are few that useful staining paraffin-embedded tissues. We have raised MAbs against human FGFR1 FGFR2 in both rats mice using bacterial recombinant fusion proteins as immunogens. used peptide epitope...
Alkaptonuria (AKU) is caused by lack of homogentisate 1, 2 dioxygenase (HGO) activity. From the complete sequence a human HGO cDNA, primers were designed in order to obtain reverse transcription–polymerase chain reaction products from tissues with ectopic transcription amenable diagnostic analysis. A search for mutations cDNA was performed an AKU family using urine and blood samples. The results show cosegregation (Z = 6.32; θ 0) between C→T transition at position 817 AKU. This mutation...