A5058395283- Mitochondrial Function and Pathology
- Machine Learning in Bioinformatics
- Genomics and Rare Diseases
- Cell death mechanisms and regulation
- Microtubule and mitosis dynamics
- Infections and bacterial resistance
- Epilepsy research and treatment
- Neuroscience and Neuropharmacology Research
- Antibiotic Resistance in Bacteria
- Metabolism and Genetic Disorders
- Mycobacterium research and diagnosis
University of Pisa
2024
Fondazione IRCCS Istituto Neurologico Carlo Besta
2020-2022
Abstract Neuronal dendritic arborizations and spines are crucial for a normal synaptic transmission may be critically involved in the pathophysiology of epilepsy. Alterations morphology spine loss mainly hippocampal neurons have been reported both epilepsy animal models human brain tissues from patients with However, it is still unclear whether these abnormalities relate to cause or generated by seizure recurrence. We investigated fine neuronal structures at level organization using Golgi...
Leber's Hereditary Optic Neuropathy (LHON) is a maternally inherited disorder caused by homoplasmic mutations of mitochondrial DNA (mtDNA). LHON characterized the selective degeneration retinal ganglion cells (RGC). Almost all maternal lineages are mutant (100% mtDNA copies mutant) for one three frequent now found in over 90% patients worldwide (m.11778G > A/MT-ND4, m.3460G A/MT-ND1, m.14484 T C/MT-ND6). Human induced pluripotent stem (hiPSCs) were generated from patient carrying A/MT-ND1...
Sheep farming for milk production is an important sector of the Italian agricultural industry. Italy has a significant annual sheep production, which amounted to 477.000 ton in 2021 and almost exclusively employed cheeses production. The aim this work was evaluate prevalence beta-lactams-resistant bacteria (methicillin-resistant staphylococci Gram-negative bacteria) bulk tank ovine collected from 97 farms located central (Tuscany Lazio). Samples were screened presence resistant...
Pearson marrow pancreas syndrome (PMPS) is a sporadic mitochondrial disease, resulting from the clonal expansion of mutated DNA (mtDNA) molecule bearing macro-deletion, and therefore missing essential genetic information. PMPS characterized by presence deleted (Δ) mtDNA that co-exist with variable amount wild-type mtDNA, condition termed heteroplasmy. All tissues affected individual, including haemopoietic system post-mitotic, highly specialized (brain, skeletal muscle, heart) contain...