A5004823404- Genetic Neurodegenerative Diseases
- Musculoskeletal pain and rehabilitation
- Face Recognition and Perception
- Glioma Diagnosis and Treatment
- Spatial Neglect and Hemispheric Dysfunction
- Psychosomatic Disorders and Their Treatments
- Dementia and Cognitive Impairment Research
- Stroke Rehabilitation and Recovery
- Cancer-related cognitive impairment studies
- Brain Metastases and Treatment
- EEG and Brain-Computer Interfaces
- Neural and Behavioral Psychology Studies
- Autism Spectrum Disorder Research
- Advanced Neuroimaging Techniques and Applications
- Balance, Gait, and Falls Prevention
- Visual perception and processing mechanisms
- Older Adults Driving Studies
- Acute Ischemic Stroke Management
- Bone and Joint Diseases
- Neurological and metabolic disorders
- Olfactory and Sensory Function Studies
- Hallucinations in medical conditions
- Histone Deacetylase Inhibitors Research
- Fetal and Pediatric Neurological Disorders
- Botulinum Toxin and Related Neurological Disorders
University Medical Center Groningen
2013-2025
University of Groningen
2018-2025
Chicago Neuropsychology Group
2013
Abstract Mid-level visual processing represents a crucial stage between basic sensory input and higher-level object recognition. The conventional model posits that fundamental qualities like color motion are processed in specialized, retinotopic brain regions (e.g., V4 for color, MT/V5 motion). Using atlas-based lesion-symptom mapping disconnectome maps cohort of 307 ischemic stroke patients, we examined the neuroanatomical correlates underlying eight mid-level qualities. Contrary to...
Background: Diffusion weighted imaging (DWI) is used for monitoring purposes lower-grade glioma (LGG). While the apparent diffusion coefficient (ADC) clinically used, various DWI models have been developed to better understand micro-environment. However, validity of these and how they relate each other currently unknown. Therefore, this study assesses agreement models. Methods: Fourteen post-treatment LGG patients six healthy controls (HC) underwent MRI on a 3T scanner. processing included...
Abstract An increasing amount of research has shown a cerebellar involvement in higher order cognitive functions, including emotional processing and decision-making. However, it not been investigated whether impairments facial emotion recognition, which could be marker impaired experiences, are related to risky decision-making these patients. Therefore, we aimed investigate recognition patients as well relationship between constructs. Thirteen with discrete, isolated, lesion consequence...
Facial expressions have a communicatory function and the ability to read them is prerequisite for understanding feelings thoughts of other individuals. Impairments in recognition facial emotional are frequently found patients with neurological conditions (e.g. stroke, traumatic brain injury, frontotemporal dementia). Hence, standard neuropsychological assessment should include measurement emotion recognition. However, there debate regarding which tests most suitable. The current study...
Neuropsychological tests, particularly for episodic memory, are used to classify patients in memory clinics. Still, the differential diagnosis between dementia of Alzheimer's disease type (Dementia-AD), mild cognitive impairment (MCI), or major depressive disorder (MDD) is challenging. However, impairments other domains, such as emotion recognition, an aspect social cognition, might have additional value distinguishing Dementia-AD from MCI and MDD hence signal progression neurodegeneration....
We describe the phenomenon of crossed cerebellar diaschisis (CCD) in four subjects diagnosed with Alzheimer's disease (AD) according to National Institute on Aging - Alzheimer Association (NIA-AA) criteria, combination 18F-FDG PET and 11C-PiB imaging.18F-FDG showed a pattern cerebral metabolism relative decrease most prominent frontal-parietal cortex left hemisphere hypometabolism right cerebellum. symmetrical amyloid accumulation, but lower tracer delivery (a surrogate blood flow)...
Objective: Emotion recognition, an important aspect of social cognition, can be impaired already in early Alzheimer disease dementia and amnestic mild cognitive impairment (aMCI) may underly behavioral changes, which increase caregiver burden. However, behavior is difficult to assess outpatient settings. We evaluated whether emotion recognition related proxy-rated problems thus serve as a marker these changes. Patients Method: was assessed with Ekman 60 Faces Test (EFT-total, 6 separate...
Working memory and episodic are two different processes, although the nature of their interrelationship is debated. As these processes predominantly studied in isolation, it unclear whether they crucially rely on neural substrates. To obtain more insight this, 81 adults with sub-acute ischemic stroke 29 elderly controls were assessed a visual working task, followed by surprise subsequent test for same stimuli. Multivariate, atlas- track-based lesion-symptom mapping (LSM) analyses performed...
To investigate the clinical relevance of radiotherapy (RT) dose bath in patients treated for lower grade glioma (LGG).Patients (n = 17) with RT LGG were assessed neurocognitive function (NCF) tests and structural Magnetic Resonance Imaging (MRI) categorized subgroups based on tumour lateralisation. dose, volumetric results cerebral microbleed (CMB) number extracted contralateral cerebrum, hippocampus, cerebellum. The target volume (CTV) was included analysis as a surrogate focal other...
Abstract Objectives: Neurodegenerative diseases (NDDs), such as Alzheimer’s disease, frontotemporal dementia, dementia with Lewy bodies, and Huntington’s inevitably lead to impairments in higher-order cognitive functions, including the perception of emotional cues decision-making behavior. Such are likely cause risky daily life behavior, for instance, traffic. Impaired recognition expressions, fear, is considered a marker impaired experience emotions. Lower fear can, turn, be related...
Deficits in facial emotion recognition occur frequently after stroke, with adverse social and behavioural consequences. The aim of this study was to investigate the neural underpinnings emotional expressions, particular distinct basic emotions (anger, disgust, fear, happiness, sadness surprise). A group 110 ischaemic stroke patients lesions (sub)cortical areas cerebrum included. Emotion assessed Ekman 60 Faces Test FEEST. Patient data were compared 162 matched healthy controls (HC’s). For...
Background: Impaired cognition can be a late effect after treatment in long-term testicular cancer (TC) survivors, negatively affecting their daily life. However, little data is available beyond 20 years post-treatment. We assessed cognitive impairment very TC survivors CT or RT and compared the results with stage I controls. Methods: In this cross-sectional multicenter cohort study, we enrolled (treated orchiectomy followed by only)—with follow-up duration ≥ years—and age-matched healthy...
There is a growing interest in deep brain stimulation (DBS) of the nucleus basalis Meynert (NBM) as potential therapeutic modality for Parkinson's disease dementia (PDD). Low-frequency has yielded encouraging results individual patients; however, these are not yet sustained larger studies. With aim to expand understanding NBM-DBS, we share our experience with serendipitous NBM-DBS patients treated DBS internal Globus pallidus (GPi) disease. Since NBM anatomically located ventral GPi, several...
Objective: To explore driving performance and safety in patients with cervical dystonia (CD) on a simulated lane tracking, intersections highway ride to compare it healthy controls. Design: This study was performed as an explorative between groups comparison. Participants: Ten CD idiopathic CD, 30 years or older, stable botulinum toxin treatment for over year, holding valid driver's license being active driver were compared 10 controls, matched age gender. Main outcome measures: Driving...
Micropsia is a rare condition in which patients perceive the outside world smaller size than it actually is. We examined patient who, after right occipito-parietal stroke, subjectively reported perceiving everything at seventy percent of actual size. Using experimental tasks, we confirmed extent his micropsia 70%. Visual half-field tests showed an impaired perception shape, location and motion left visual field. As concerns complete field, suggest that caused by higher-order compensation...
<h3>Background</h3> Fitness to drive (FTDr) and mobility in general are important aspects of quality life. However, the cognitive, motor, visual functions required for adequate procedural driving skills a motor vehicle show progressive decline HD. Furthermore, patients with HD at greater risk overestimating their own FTDr due impaired self-awareness (Paulsen, 2011), which could lead potential dangerous traffic situations. <h3>Objective</h3> Correctly identify by means classic...