A5065555267- Pediatric Pain Management Techniques
- Infant Development and Preterm Care
- Anesthesia and Neurotoxicity Research
- Neonatal Respiratory Health Research
- Anesthesia and Sedative Agents
- Intensive Care Unit Cognitive Disorders
- Pain Mechanisms and Treatments
- Cardiac, Anesthesia and Surgical Outcomes
- Infant Health and Development
- Neuroscience of respiration and sleep
- Neonatal and fetal brain pathology
- Congenital Diaphragmatic Hernia Studies
- Advanced Neuroimaging Techniques and Applications
- Family and Patient Care in Intensive Care Units
- Genetic Syndromes and Imprinting
- Pharmaceutical studies and practices
- Infrared Thermography in Medicine
- Pain Management and Opioid Use
- Ethics and Legal Issues in Pediatric Healthcare
- Hereditary Neurological Disorders
- Medical and Biological Ozone Research
- Acupuncture Treatment Research Studies
- Health, Education, and Physical Culture
- Hedgehog Signaling Pathway Studies
- Myasthenia Gravis and Thymoma
Erasmus MC - Sophia Children’s Hospital
2016-2025
Universitat Pompeu Fabra
2024-2025
Hospital Del Mar
2024
Erasmus MC
2012-2023
Erasmus University Rotterdam
2013-2023
Digestive Care (United States)
2014
Leiden University
2013
St. Antonius Ziekenhuis
2013
Importance Continuous morphine infusion as standard postoperative analgesic therapy in young infants is associated with unwanted adverse effects such respiratory depression.Objective To determine whether intravenous paracetamol (acetaminophen) would significantly (Ͼ30%) reduce requirements neonates and after major surgery.Design, Setting, Patients Single-center, randomized, double-blind study conducted a level 3 pediatric intensive care unit Rotterdam, the Netherlands.Patients were 71 or...
Newborns admitted to the neonatal intensive care unit (NICU) regularly undergo painful procedures and may face various conditions such as postoperative pain. Optimal management of pain in these vulnerable preterm term born neonates is crucial ensure their comfort prevent negative consequences This entails accurate timely identification pain, non-pharmacological treatment if needed administration analgesic therapy, evaluation effectiveness, monitoring adverse effects. Despite widely...
Severe acute asthma in children is associated with substantial morbidity and may require pediatric ICU (PICU) admission. The aim of the study was to determine risk factors for PICU admission.The used a retrospective multicenter case-control design. cases included admitted because severe history out-patient treatment by pediatricians or pulmonologists. Controls were without admission asthma. matched sex, age, hospital, time elapsed since diagnosis Fourteen possible analyzed.Sixty-six 164...
Working memory (WkM) is a fundamental cognitive process that serves as building block for higher order functions. While studies have shown children and adolescents utilize similar brain regions during verbal WkM, there been few evaluate the developmental differences in connectivity. Our goal was to study development of connectivity related WkM typically developing adolescents. Thirty-five healthy adolescents, divided into three groups: 9-12 (children), 13-16 (young adolescents), 17-19 (older...
<b><i>Background:</i></b> Traditionally, 10 years ago, children born preterm often routinely received morphine, especially during mechanical ventilation. Studies in neonatal rats, whose stage of brain development roughly corresponds to that preterm, found negative long-term effects after pain and opioid exposure. <b><i>Objectives:</i></b> We studied possible prematurity, procedural opioids humans later. hypothesized these factors would...
Abstract Background Necrotizing enterocolitis (NEC) is a highly painful intestinal complication in preterm infants that requires adequate pain management to prevent short- and long-term effects of neonatal pain. There lack international guidelines for NEC patients. Therefore, this study aims describe current patients European intensive care units (NICUs). Methods An online survey was designed conducted assess practices NICUs. The distributed via societies, digital platforms, professional...
Aim To examine the neurobiology of long‐term neuropsychological deficits after neonatal extracorporeal membrane oxygenation ( ECMO ). Method This cross‐sectional study assessed white matter integrity and hippocampal volume survivors (8–15y) healthy children (8–17y) using diffusion tensor imaging DTI ) structural magnetic resonance MRI respectively. Neuropsychological outcome was evaluated in survivors. Included clinical predictors integrity: age start , duration, highest index before mean...
Quantitative sensory testing (QST) is often used to measure children's and adults' detection- pain thresholds in a quantitative manner. In children especially the Thermal Sensory Analyzer (TSA-II) applied determine thermal detection thresholds. As comparisons between studies are hampered by different protocols used, we aimed present standard protocol reference values for children. Our includes reaction time dependent independent tests takes about 14–18 min complete. Reference were obtained...
We present a case study of 10-year-old child with severe burns that were misinterpreted as inflicted burns. Because multiple injuries since early life, the family was under suspicion abuse and therefore supervision Child Care Board for 2 years before boy burned. incurred without feeling pain, we conducted thorough medical examination laboratory testing, evaluated detection pain thresholds, used MRI to brain morphology activation patterns during between this patient 3 healthy age-...
Background: While parent-delivered pain management has been demonstrated to effectively reduce neonatal procedural responses, little is known about what extent it utilized. Our aim was explore the utilization of parents in and investigate whether local guidelines promote interventions. Methods: A web-based survey distributed units worldwide. Results: The majority 303 responding intensive care (NICUs) from 44 countries were situated high-income Europe Central Asia. Of units, 67% had...
Adequate pain management for preterm born neonates suffering from the extremely painful disease necrotizing enterocolitis (NEC) is essential, since neonatal exposure to related negative short-term and long-term consequences. The aim of this study was describe current its effectiveness in NEC patients.In single-center, retrospective study, (gestational age < 32 weeks and/or birth weight 1500 g) with Bell's stage II or III were included. Information on (based COMFORTneo NRS scores) analgesic...
Pain sensitivity is an inherited factor that varies strongly between individuals. We investigated whether genetic polymorphisms in the candidate genes COMT, OPRM1, OPRD1, TAOK3, TRPA1, TRPV1, and SCN9A are contributing to experimental pain variability children. Our study included 136 children adolescents (8-18 years). Cold heat thresholds were determined with a Thermal Sensory Analyzer. Women young significantly more sensitive (P < 0.05). After correction for age, gender, reaction time,...
Prader-Willi syndrome (PWS) is a complex neurodevelopmental disorder, characterized by endocrine problems and hyperphagia, indicating hypothalamic-pituitary dysfunction. However, few studies have explored the underlying neurobiology of hypothalamus its functional connectivity with other brain regions. Thus, aim this study was to examine anatomical differences hypothalamus, mammillary bodies, pituitary gland as well resting state in children PWS. Twenty-seven PWS (13 DEL, 14 mUPD) 28...
<h3>BACKGROUND AND PURPOSE:</h3> Infants born preterm are commonly diagnosed with structural brain lesions known to affect long-term neurodevelopment negatively. Yet, the effects of birth on development in absence intracranial remain be studied detail. In this study, we aim quantify long term consequences specific group. <h3>MATERIALS METHODS:</h3> Neonatal cranial sonography and follow-up T1-weighted MR imaging DTI were performed evaluate whether anatomic characteristics cerebrum cerebellum...
Prader–Willi Syndrome (PWS) is a complex neurogenetic disorder caused by loss of the paternal 15q11.2–q13 locus, due to deletion (DEL), maternal uniparental disomy (mUPD), or imprinting center defects. Individuals with mUPD have up 60% risk developing psychosis in early adulthood. Given increasing evidence for white matter abnormalities psychotic disorders, we investigated microstructure children and adolescents PWS, particular emphasis on DEL subtypes. Magnetic resonance diffusion weighted...