A5112888857- Glioma Diagnosis and Treatment
- Cancer-related molecular mechanisms research
- Cancer Research and Treatments
- Cancer Cells and Metastasis
- RNA Research and Splicing
- RNA modifications and cancer
- Cancer Genomics and Diagnostics
- Protein Degradation and Inhibitors
- Radiopharmaceutical Chemistry and Applications
- Pharmacogenetics and Drug Metabolism
- Intracerebral and Subarachnoid Hemorrhage Research
- Computational Drug Discovery Methods
- Spinal Hematomas and Complications
- Chemical Reactions and Isotopes
- Protein Interaction Studies and Fluorescence Analysis
- Medical Imaging Techniques and Applications
- Drug Transport and Resistance Mechanisms
- Microtubule and mitosis dynamics
- Nanoplatforms for cancer theranostics
- Neurosurgical Procedures and Complications
- Analytical Chemistry and Chromatography
Amsterdam University Medical Centers
2020-2024
University of California, San Diego
2020-2024
Cancer Center Amsterdam
2018-2024
Erasmus University Rotterdam
2020
Amsterdam Neuroscience
2020
The Nature Conservancy
2019
Amsterdam UMC Location Vrije Universiteit Amsterdam
2017
Personalized cancer treatments using combinations of drugs with a synergistic effect is attractive but proves to be highly challenging. Here we present an approach uncover the efficacy drug based on analysis mono-drug effects. For this used dose-response data from pharmacogenomic encyclopedias and represent these as atlas. The atlas represents relations between effects allows identify independent processes for which tumor might particularly vulnerable when attacked by two drugs. Our enables...
The blood–brain barrier (BBB) represents a major obstacle to delivering drugs the central nervous system (CNS), resulting in lack of effective treatment for many CNS diseases including brain cancer. To accelerate drug development, computational prediction models could save time and effort needed experimental evaluation. Here, we studied BBB permeability focusing on active transport (influx efflux) as well passive diffusion using previously published self-curated data sets. We created based...
Targeted therapy against driver mutations responsible for cancer progression has been shown to be effective in many tumor types. For glioblastoma (GBM), the epidermal growth factor receptor (EGFR) gene is most frequently mutated oncogenic and therefore considered an attractive target therapy. However, so far responses EGFR-pathway inhibitors have disappointing. We performed exhaustive analysis of mechanisms that might account resistance EGFR inhibition. define two major propose modalities...
Glioblastoma (GBM) is a highly aggressive and lethal brain cancer type. PI3K MAPK inhibitors have been studied preclinically in GBM as monotherapy, but not combination with radiotherapy, which key component of the current standard treatment GBM. In our study, cell lines patient representative primary cultures were grown multicellular spheroids. Spheroids treated panel small-molecule drugs including MK2206, RAD001, BEZ235, MLN0128, MEK162, alone irradiation. Following treatment, spheroid...
Chronic subdural hematoma (CSDH) is a condition that frequently seen in the neurological and neurosurgical practice. Surgical treatment overall preferred; however, conservative also an option. Both surgical of CSDH vary across neurosurgeons. The aim present study was to evaluate different strategies for among neurosurgeons countries. We designed survey sent affiliated with Congress Neurological Surgeons.The questions were related methods CSDH. Furthermore, we included post-operative care....
<div>Abstract<p>Glioblastoma (GBM) is a highly aggressive and lethal brain cancer type. PI3K MAPK inhibitors have been studied preclinically in GBM as monotherapy, but not combination with radiotherapy, which key component of the current standard treatment GBM. In our study, cell lines patient representative primary cultures were grown multicellular spheroids. Spheroids treated panel small-molecule drugs including MK2206, RAD001, BEZ235, MLN0128, MEK162, alone irradiation....
Abstract Glioblastoma Multiforme (GBM) is the most common and aggressive brain tumor, containing intrinsic resistance to current therapies leading poor clinical outcomes. Therefore, understanding underlying mechanisms of GBM an urgent medical need. Although radiotherapy contributes significantly patient survival, GBMs recur typically within initial radiation target volume, suggesting remaining cells are highly radioresistant. Deregulation protein translation mechanism has been shown...
<div>Abstract<p>Glioblastoma (GBM) is a highly aggressive and lethal brain cancer type. PI3K MAPK inhibitors have been studied preclinically in GBM as monotherapy, but not combination with radiotherapy, which key component of the current standard treatment GBM. In our study, cell lines patient representative primary cultures were grown multicellular spheroids. Spheroids treated panel small-molecule drugs including MK2206, RAD001, BEZ235, MLN0128, MEK162, alone irradiation....
<p>Supplemental Figure 1. Chemical structures of non-FDA approved compounds used in the Study; Supplemental 2. Effect drugs on growth and target phosphorylation; 3. mTOR inhibition does not show dose dependent Radiosensitization; 4. MEK162 + RT abrogate spheroid regrowth; 5. radiosensitizes GBM8 primary culture increases γH2AX levels; 6. abrogates BrdU washout sub-G1 accumulation BrdU+ cells; 7. vivo; Table 1: Antibodies used; 2: Gene signature MEK+RT response</p>
<p>Supplemental Figure 1. Chemical structures of non-FDA approved compounds used in the Study; Supplemental 2. Effect drugs on growth and target phosphorylation; 3. mTOR inhibition does not show dose dependent Radiosensitization; 4. MEK162 + RT abrogate spheroid regrowth; 5. radiosensitizes GBM8 primary culture increases γH2AX levels; 6. abrogates BrdU washout sub-G1 accumulation BrdU+ cells; 7. vivo; Table 1: Antibodies used; 2: Gene signature MEK+RT response</p>
Abstract Background Glioblastoma Multiforme (GBM) is the most common and aggressive brain tumor, containing intrinsic resistance to current therapies leading poor clinical outcomes. Therefore, understanding underlying mechanisms of GBM an urgent medical need. Although radiotherapy contributes significantly patient survival, GBMs recur typically within initial radiation target volume, suggesting remaining cells are highly radioresistant. Deregulation protein translation mechanism has been...