A5023073998- Hip disorders and treatments
- Scoliosis diagnosis and treatment
- Spinal Fractures and Fixation Techniques
- Bone fractures and treatments
- Orthopaedic implants and arthroplasty
- Cellular Mechanics and Interactions
- Advanced Fluorescence Microscopy Techniques
- Orthopedic Surgery and Rehabilitation
- Cardiomyopathy and Myosin Studies
- Shoulder Injury and Treatment
- Muscle Physiology and Disorders
- Lipid Membrane Structure and Behavior
- Cardiac Valve Diseases and Treatments
- Spine and Intervertebral Disc Pathology
- Neurogenetic and Muscular Disorders Research
- Foot and Ankle Surgery
- Lower Extremity Biomechanics and Pathologies
- Hip and Femur Fractures
- Photosynthetic Processes and Mechanisms
- Cerebral Palsy and Movement Disorders
- Drug Transport and Resistance Mechanisms
- Pelvic and Acetabular Injuries
- Cellular transport and secretion
- Genital Health and Disease
- Orthopedic Infections and Treatments
KU Leuven
2004-2024
University of New England
2010-2022
Orthopaedic Research
2021
University of Brescia
2018
Universitair Ziekenhuis Leuven
2017
Orthopedic One
2012
In-Q-Tel
2003-2006
University of Hawaiʻi at Mānoa
2004-2005
University of Hawaii System
2005
York University
1985-2001
This study illustrates that Plekhm1 is an essential protein for bone resorption, as loss-of-function mutations were found to underlie the osteopetrotic phenotype of incisors absent rat well intermediate type human osteopetrosis. Electron and confocal microscopic analysis demonstrated monocytes from a patient homozygous mutation differentiated into osteoclasts normally, but when cultured on dentine discs, failed form ruffled borders showed little evidence resorption. The presence both RUN...
Ilizarov's method of monofocal compression was used in 30 humeri with a diaphyseal pseudarthrosis. Twenty-one patients had previous surgery but loosening the osteosynthesis material. Nine initially were treated hanging cast, resulting interfragmentary distraction. Fourteen nonunions hypertrophic, and 16 atrophic, which six infected. A complete circular frame only first nine patients, whereas remaining 21 modified semicircular fixator. Union obtained all two an average consolidation time 4.5...
We reviewed 59 hips in 44 children with slipped capital femoral epiphysis (SCFE), all treated by situ pinning. The average clinical and radiographic follow-up was 11.4 years. Fifty-three (90%) were rated as either excellent or good. Osteonecrosis chondroly-sis developed five patients. Postoperative remodeling noted, not only a process of local resorption apposition bone, but also correction the disturbed anatomic axes, proportion to severity slip, together global thickening neck. believe...
Despite early screening programs and new therapeutic strategies, metastatic breast cancer is still the leading cause of death in women industrialized countries regions. There a need for novel biomarkers susceptibility, progression, response. Global analyses or systems science approaches with omics technologies offer concrete ways forward biomarker discovery cancer. Previous studies have shown that expression profilin-1 (PFN1), ubiquitously expressed actin-binding protein, downregulated...
Genua valga are not merely a cosmetic problem but also predispose to gonarthrosis in adult life. In our retrospective study of 25 patients, we reviewed present technique medial hemiepiphysiodesis using percutaneous screws and compared it with own results stapling.Clinical evaluation was performed by estimation the intermalleolar distance, radiological assessment measuring hip-knee-ankle angle until skeletal maturity. Average chronological age at time surgery 14.5 years for boys 12.7 girls....
Spinal deformities are considered an important complication of neuromuscular disorders such as spinal muscular atrophy (SMA). SMA patients typically develop progressive early-onset scoliosis, which is associated with increased functional decline, discomfort, and respiratory dysfunction. Over the second decade twenty-first century, a lot has changed in terms therapeutic options available to people SMA. Specifically, use pharmaceutical agents nusinersen (Spinraza), onasemnogene abeparvovec...
The split posterior tibial tendon transfer procedure was first reported by Green for correction of equinovarus hindfoot deformity in patients with cerebral palsy. A modification the combined an Achilles lengthening is described 17 children (21 procedures) a minimum follow-up 3 years. This modified technique indicated young continuously spastic to correct dynamic equinovarus. It restores active dorsiflexion when anterior and extensor muscles are weak. half tibialis transferred through...
The influence of DNase I binding to Ca-ATP-G-actin and Ca2+/Mg2+ ATP/ADP exchange on the conformation G-actin were investigated by measuring fluorescence dansyl cadaverine (DC) conjugated Gln41 in subdomain 2 protein. Fluorescence resonance energy transfer (FRET) between this probe N-[4-(dimethylamino)-3,5-dinitrophenyl]maleimide (DDPM) attached Cys374 1 was also measured. Contrary an earlier report [dos Remedios, Kiessling Hambly (1994) Synchrotron Radiation Biosciences (Chance, B.,...
Studies using gene-linkage analysis have suggested that abnormal recombination during meiosis may lead to the production of aneuploid gametes; however, there is little direct evidence a link between two in human males. We analysed spermatocytes pachytene stage from man with extremely high aneuploidy rates his sperm. Testicular tissue specimens infertile and vasectomy reversals were processed immuofluorescent techniques visualize synaptonemal complex foci fluorescent situ hybridization on...