A5062708357- Hormonal Regulation and Hypertension
- Adrenal and Paraganglionic Tumors
- Adrenal Hormones and Disorders
- Hypothalamic control of reproductive hormones
- Genetic and Clinical Aspects of Sex Determination and Chromosomal Abnormalities
- Hormonal and reproductive studies
- Sexual Differentiation and Disorders
- Sperm and Testicular Function
- Machine Learning in Healthcare
- Medical Imaging and Pathology Studies
- Pituitary Gland Disorders and Treatments
- Menopause: Health Impacts and Treatments
- Ovarian function and disorders
- Parathyroid Disorders and Treatments
- Artificial Intelligence in Healthcare and Education
- Head and Neck Surgical Oncology
- Viral-associated cancers and disorders
- Estrogen and related hormone effects
- Assisted Reproductive Technology and Twin Pregnancy
- Immunodeficiency and Autoimmune Disorders
- Pharmacology and Obesity Treatment
- Palliative Care and End-of-Life Issues
- Electronic Health Records Systems
- Thyroid Cancer Diagnosis and Treatment
- Cardiovascular, Neuropeptides, and Oxidative Stress Research
Singapore General Hospital
2014-2024
Weatherford College
2022
Central South University
2021
SingHealth
2019-2021
Duke-NUS Medical School
2020
Royal Victoria Infirmary
2019
Newcastle upon Tyne Hospitals NHS Foundation Trust
2019
Newcastle upon Tyne Hospital
2019
Newcastle University
2019
Prediction models have been developed to predict either unilateral or bilateral primary aldosteronism, and these not validated externally. We aimed develop a simplified score both subtypes validate this externally.Our development cohort was taken from 165 patients who underwent adrenal vein sampling (AVS) in two Asian tertiary centres. Unilateral disease determined using AVS postoperative outcome. Multivariable analysis used construct prediction models. our tool European of 97 enrolled the...
Background The clinical management of type 2 diabetes mellitus (T2DM) presents a significant challenge due to the constantly evolving practice guidelines and growing array drug classes available. Evidence suggests that artificial intelligence (AI)–enabled decision support systems (CDSSs) have proven be effective in assisting clinicians with informed decision-making. Despite merits AI-driven CDSSs, research gap exists concerning early-stage implementation adoption AI-enabled CDSSs T2DM...
OPINION article Front. Endocrinol., 11 October 2019Sec. Reproduction Volume 10 - 2019 | https://doi.org/10.3389/fendo.2019.00685
Studies find surgery superior to medications in the treatment of primary aldosteronism (PA). It would be ideal compare surgical and medical therapy patients with unilateral PA only, who have option between these modalities. However, this is challenging as most on adrenal vein sampling (AVS) undergo surgery.To outcomes confirmed or likely PA.Retrospective cohort study 274 managed at two referral centres from 2000 2019.154 identified using AVS a validated clinical prediction model were treated...
Background Adrenal insufficiency (AI) is potentially life-threatening, and accurate diagnosis crucial. The first-line diagnostic test, the adrenocorticotrophic hormone (ACTH) stimulation measures serum total cortisol. However, this affected in states of altered albumin or cortisol-binding globulin levels, limiting reliability. Salivary cortisol reflects free bioactive levels a promising alternative. few studies are available, heterogenous methodologies limit applicability. Methods This study...
Abstract The evolution of trabecular bone score (TBS) and mineral density (BMD) over the first 5 years after renal transplantation was prospectively evaluated in 164 patients. Dual energy X‐ray absorptiometry (DXA) scans were performed at 0, 6, 12, 24, 60 months. Cumulative steroid dose, serum 25(OH)D, calcium, parathyroid hormone, total ALP levels these time points checked. Incident fractures identified from X‐rays/vertebral fracture assessments. Mean (SD) age, TBS, lumbar spine BMD...
Abstract Introduction Patients with primary aldosteronism (PA) have increased cardiovascular risk, and there are concerns about the efficacy of medical therapy. Objective We aimed to assess long-term tolerability therapy in PA patients. Methods conducted a retrospective study on 201 patients treated (spironolactone, eplerenone, or amiloride) from 2000 2020 at 2 tertiary centers. Clinical biochemical control side effects were assessed. Results Among 155 medications, 57.4% achieved blood...
OPINION article Front. Endocrinol., 12 June 2019Sec. Reproduction Volume 10 - 2019 | https://doi.org/10.3389/fendo.2019.00372
Aim To implement an inpatient glucose management (IGM) programme in the general medical wards and evaluate its clinical efficacy. Method Consecutive patients admitted to selected over a 12-month period were included IGM programme. All with ≥3 capillary blood (CBG) readings (>10.0 mmol/L and/or <4.0 mmol/L) 24-hour identified electronically. A multidisciplinary team of diabetes care providers would provide specialist input these patients. The control group comprised consecutive preceding 12...
Abstract Context Primary aldosteronism (PA) is a common cause of hypertension (HT). However, diagnosis often delayed, leading to poorer clinical outcomes. Hypokalemia with HT characteristic PA, and an indication for screening. Objective We evaluated if patients PA had prolonged hypokalemia before diagnosis, the subsequent biochemical/clinical control, factors associated delayed diagnosis. Methods Our study included all diagnosed between 2001 2022. Delayed was defined as duration more than 1...
Abstract Pallister-Hall syndrome is a rare autosomal dominant condition that associated with polydactyly and hypothalamic hamartoma caused predominantly by frameshift or nonsense pathogenic variants in the GLI3 gene. The majority of cases are identified during childhood; however, reports diagnoses adulthood exist. Here, we describe identification novel variant an adult male following incidental detection hamartoma.
Abstract Disclosure: P. Kek: None. D. Swee: C. khoo: T. Puar: Introduction Primary aldosteronism (PA) is the most common cause of endocrine hypertension. We present a case PA recurrence post-adrenalectomy which was localized with 11C-Metomidate PET-CT. Clinical A 57-year-old Chinese male presented to Endocrinology in 2013 for left adrenal incidentaloma while being evaluated renal cyst. He had Diabetes mellitus type 2 1 year and hypertension years. Computed tomography intravenous pyelography...
<sec> <title>BACKGROUND</title> The clinical management of type 2 diabetes mellitus (T2DM) presents a significant challenge due to the constantly evolving practice guidelines and growing array drug classes available. Evidence suggests that artificial intelligence (AI)–enabled decision support systems (CDSSs) have proven be effective in assisting clinicians with informed decision-making. Despite merits AI-driven CDSSs, research gap exists concerning early-stage implementation adoption...